Results 61 to 70 of about 3,824,363 (314)

Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort

Respiratory Research, 2020
Rationale Gastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency room visits, costs, and quality-of ...
Arianne K. Baldomero, Chris H. Wendt, Ashley Petersen, Nathaniel T. Gaeckle, MeiLan K. Han, Ken M. Kunisaki, for the COPDGene Investigators   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Vulnerability analysis of interdependent critical infrastructures : case study of the Swedish railway system

, 2011
Critical infrastructures provide essential services which enable our society to function. Disruptions in infrastructures can have widespread effects, not only for the originating infrastructure but also, through mutual dependencies, for other ...
Hassel, Henrik,, Cedergren, Alexander,, Johansson, Jonas,, Lund University.   +3 more
core   +1 more source

Identification and management of incidental findings in a Veteran’s lung cancer screening program

Respiratory Research
Background Incidental findings (IFs) are common on low dose CT obtained during lung cancer screening (LCS). The identification and management of clinically significant IFs is a challenging aspect of LCS programs and there is no standardized method of ...
Renee L. Colucci, Eric Garshick, Julie White, Emily S. Wan, Julianne O’Leary, Lisa A. Blake, Samantha M. Hoyt, Demerise Johnston, Kathleen LaCerda, Michelle Morreale-Karl, Anupma Jati, Fatima G. Wilder, Daniel C. Wiener, Justin M. Rucci, Ronald H. Goldstein   +14 more
doaj   +1 more source

Neurovirulent cytokines increase neuronal excitability in a model of coronavirus-induced neuroinflammation

Intensive Care Medicine Experimental, 2023
Background Neurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus clearance.
Salil R. Rajayer, Stephen M. Smith
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Conceptual design for data flow for a database management system for the sustainable recovery of critical metals from waste electrical and electronic equipment

, 2018
Sustainable recovery of critical metals (CM) from Waste Electrical and Electronic Equipment (WEEE) in the European Union (EU) requires information for detailed analysis, monitoring and decision-making.
Kousaiti, Athanasia, Peñaherrera Vaca, Fernando Andrés, Reinhardt, Robert   +2 more
core   +1 more source

Real‐world use of inhaled treprostinil for lung disease‐pulmonary hypertension: A protocol for patient evaluation and prescribing

Pulmonary Circulation, 2022
Inhaled treprostinil was approved recently for interstitial lung disease‐pulmonary hypertension; however, efficacy in “real‐world” populations is not known.
Shelsey W. Johnson, Lauren Finlay, Stephen C. Mathai, Ronald H. Goldstein, Bradley A. Maron   +4 more
doaj   +1 more source

Critical fragility in sociotechnical systems

Proceedings of the National Academy of Sciences
Sociotechnical systems, where technological and human elements interact in a goal-oriented manner, provide important functional support to our societies. Here, we draw attention to the underappreciated concept of timeliness—i.e., system elements being available at the right place at the right time—that has been ubiquitously and integrally adopted as a ...
José Moran, Frank P. Pijpers, Utz Weitzel, Jean-Philippe Bouchaud, Debabrata Panja   +4 more
openaire   +6 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source