Results 51 to 60 of about 613,272 (249)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
CRITICAL THEORY AND SOCIAL SCIENCE
Kanz Philosophia: A Journal for Islamic Philosophy and MysticismThis research addresses the contemporary global conflict surrounding transformations in social life through the lens of Critical Theory. The urgency of analyzing the thoughts of Herbert Marcuse and Jürgen Habermas lies in their critical engagement with ...
Muhammad Faqih Nidzom +2 more
doaj +1 more source
CRÍTICA DEL PENSAMIENTO CRÍTICO. APUNTES PARA PENSAR LAS LUCHAS
Revista Latinoamericana de Derechos Humanos, 2015 Resumen El texto pretende establecer un diálogo a lo interno de la tradición crítica, y, por tanto, desde las preocupaciones de fondo que han marcado su quehacer.
Manuel E. Gándara Carballido.
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
CRITICAL THEORY AND E-EDUCATION
Metodički Vidici, 2014 There is an evident trend of an increased use of and positive attitudes towards e-Education and distance learning within the Croatian higher education system.
Josip T. Ćirić +1 more
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Critical theory and social inequality
Tempo SocialThis paper argues that social inequality is possibly the core topic of any critical theory in the social sciences – for epistemological as well as ethical reasons.
Boike Rehbein
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source