Results 71 to 80 of about 657,159 (265)

The Criticism of Standard and the Standard of Criticism [PDF]

پژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2017
Criticism is a natural and humane phenomenon, and it originates from human’s willingness to freedom. Thought is the mental moving from the base to the result and visa-versa. So, this action is subject to evaluation and criticism.
Gholamreza Fadaie
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Bad or worse? Applying critical theory to explore the impacts of Payatas dumpsite closure on the former waste pickers. [PDF]

Waste Manag Res, 2023
Ito H, Igano C.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Critical Theory, Culture Change, and Achieving Health Equity in Health Care Settings. [PDF]

Acad Med, 2022
Todic J, Cook SC, Spitzer-Shohat S, Williams JS, Battle BA, Jackson J, Chin MH.   +6 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Political Economic Approach to Old Age: The Carroll Estes Model

Senectus
Aging, a crucial concern within social policy and services, has gained increasing attention from scholars and policymakers because of the accelerating global demographic shift toward the aging population.
Elif Çevik
doaj   +1 more source

Critical Theory or Accepted Practice? Combining Careers in Critical Care Medicine and Gastroenterology. [PDF]

Dig Dis Sci, 2022
Saffo S, Leventhal TM.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Black feminism and Artificial Intelligence: the possibilities and limitations of contesting discriminatory AI from a critical social theory perspective

Frontiers in Sociology
Artificial Intelligence (AI) has been challenged in recent years by critical scholars inspired by American Black feminism and questions around diversity, inclusion, and justice in and through AI systems.
Laura Schelenz
doaj   +1 more source