Results 111 to 120 of about 7,950,057 (368)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Malaysia and China students’ feedback on the implementation of critical thinking pedagogy: a case study [PDF]

open access: yes, 2020
Having a knowledgeable and highly skilled human capital is an important factor for Malaysia to transform its economy towards achieving a developed nation and high-income status by the year 2020.
Azid, Nurulwahida   +3 more
core  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Framing purposeful evaluation through critical systems thinking [PDF]

open access: yes, 2007
Two traditions of practice – evaluation and systems – share three significant concerns regarding development intervention: (i) making sense of complex interrelationships and the continual change brought about by such relationships; (ii) engaging with ...
Reynolds, Martin
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

To Frame or Reframe: Where Might Design Thinking Research Go Next? [PDF]

open access: yes, 2020
Design thinking is gaining widespread attention in the practitioner and academic literature. Successful implementation has been documented, and its value shown in empirical studies.
Beckman, SL
core  

The Effectiveness of Guided Inquiry Learning Model with Edmodo Assisted to Facilitate Critical Thinking Skills

open access: gold, 2021
Andri Estining Sejati   +5 more
openalex   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

“Critical Thinking: An Approach that Synthesizes Analytic Philosophy” [PDF]

open access: yes, 2017
This paper concentrates on the resurrection of the journey of analytic philosophy from the perspective of ‘critical thinking,’ a tool of proper thought and understanding.
Chakraborty, Sanjit
core  

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