Results 121 to 130 of about 8,622,922 (338)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Equity-focused developmental evaluation using critical systems thinking [PDF]
, 2012 Developmental evaluation questions the ethical basis of an intervention in terms of whether it’s ‘doing the right thing’ rather than merely ‘doing things right’.
Reynolds, Martin
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Two Modes of Non-Thinking. On the Dialectic Stupidity-Thinking and the Public Duty to Think [PDF]
, 2018 This article brings forth a new perspective concerning the relation between stupidity and thinking by proposing to conceptualise the state of non-thinking in two different ways, situated at the opposite ends of the spectrum of thinking.
Marin, Lavinia
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
From Context to Action: Establishing a Pre-Chain Phase Within the Cyber Kill Chain
Journal of Cybersecurity and PrivacyThe Cyber Kill Chain (CKC) is a prevalent concept in cyber defense; nevertheless, its emphasis on post-reconnaissance phases limits the capacity to foresee attacker activities outside the organizational boundary.
Robert Kopal +2 more
doaj +1 more source
“Critical Thinking: An Approach that Synthesizes Analytic Philosophy” [PDF]
, 2017 This paper concentrates on the resurrection of the journey of analytic philosophy from the perspective of ‘critical thinking,’ a tool of proper thought and understanding.
Chakraborty, Sanjit
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Does Critical Thinking Mean Cultural Thinking? Using Language to Learn and Develop Character [PDF]
, 2011 One of the most widely discussed concepts in education and educational reform these days is critical thinking. This thing we call critical thinking or analysis has strong cultural components.
Floriasti, T. W. (Tri)
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To Frame or Reframe: Where Might Design Thinking Research Go Next? [PDF]
, 2020 Design thinking is gaining widespread attention in the practitioner and academic literature. Successful implementation has been documented, and its value shown in empirical studies.
Beckman, SL
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