Results 51 to 60 of about 225,324 (254)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A Healthy Climbing: The Critical Care Approach [PDF]
پژوهشنامۀ انتقادی متون و برنامههای علوم انسانی, 2017 Critical assessment, as an active and organized process, has become an essential activity for a better understanding of scientific texts and clarifications of goals, highlights, and outcomes, as well as the dynamics of studies over the last few decades ...
Mehrnoush Hedayati
doaj
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Integrating Critical Thinking into Extension Programming #2: Developing Critical Thinking Skills
EDIS, 2015 This 3-page fact sheet is the second in the Integrating Critical Thinking into Extension Programming, series. It examines the virtues of critical thinking to offer suggestions for integrating activities that encourage critical thinking into Extension ...
Alexa J. Lamm
doaj +5 more sources
A Critical Perspective to Critical Thinking
Florence Nightingale Journal of Nursing, 2019 Critical thinking is a higly valued skill today not only in academic settings, especially in higher education, but also in professional enviroments. Employers expect individuals who think critically; teachers want students who think critically; society ...
Hülya Kaya
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Saber & Educar, 2015 Recognizing the importance of developing critical thinking of students research has been developed in order to establish answer to the question of how to promote this kind of thinking.
Rui Marques Vieira +1 more
doaj +1 more source