Results 81 to 90 of about 5,200,298 (246)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

From Context to Action: Establishing a Pre-Chain Phase Within the Cyber Kill Chain

Journal of Cybersecurity and Privacy
The Cyber Kill Chain (CKC) is a prevalent concept in cyber defense; nevertheless, its emphasis on post-reconnaissance phases limits the capacity to foresee attacker activities outside the organizational boundary.
Robert Kopal, Bojan Alikavazović, Zlatan Morić   +2 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Revealing the Best Strategy: A Comparative Study of PBL and PjBL in Enhancing Critical Thinking in Pancasila Education [PDF]

The purpose of this study is to compare the project-based learning and problem-based learning models in improving students' critical thinking skills in the Pancasila Education subject.
Ayu, Khoirunnisa; Universitas tidar magelang, Wahyono, Hari; Universitas tidak Magelang, Istiqomah, Annisa; Universitas negeri Yogyakarta, Widiyanto, Delfiyan; Universitas Tidar, Syifana, Sulthan; Universitas tidar Magelang   +4 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Vygotskian perspective on promoting critical thinking in young children through mother-child interactions [PDF]

, 2008
This thesis examines how mothers, as primary caretakers, might promote the development of critical thinking of their 4- and 5-year-olds. Interest in critical thinking in very young children can be traced back to the early years of the 20th century with ...
Chandra, Julia Suleeman
core  

Does writing patient care daily effects on critical thinking? A pilot study with 1st year nursing students

, 2020
Writing is a powerful way of learning. Writing may provide students with opportunities to think by discussion and use higher-level thinking skills to answer complicated problems.
Küçükakça Çelik, Gülden, Kuzgun, Hürmüs, Güven, Dilek Şefika, Calpbinici, Pelin   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Reasoning and Religion: The Relevance of the Academic Study of Religion to Critical Thinking Pedagogy [PDF]

, 2011
In this thesis I inquire into method and theory debates within the academic study of religion, arguing for the potential of this broad field to enrich critical thinking pedagogy, especially with regard to worldviews and problems associated with the ...
Goldberg, Ilan Yaakov
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source