Results 101 to 110 of about 278,381 (298)

Hospital burden of critical illness across global settings: a point prevalence and cohort study in Malawi, Sri Lanka and Sweden

BMJ Global Health
Introduction The burden of critical illness may have been underestimated. Previous analyses have used data from intensive care units (ICUs) only, and there is a lack of evidence about where in hospitals critically ill patients receive care.
Abi Beane, Rashan Haniffa, Martin Gerdin Wärnberg, Lisa Kurland, Tim Baker, Kwazizira Samson Mndolo, Cecilia Stalsby Lundborg, Miklos Lipcsey, Carl Otto Schell, Andreas Wellhagen, Anna Hvarfner, Markus Castegren, Petronella Bjurling-Sjöberg, Raphael Kazidule Kayambankadzanja,, Chamira Kodippily, Grace Banda, Nalayini Jegathesan, Christoffer Hintze, Wageesha Wijesiriwardana, Jayasingha Arachchilage Sujeewa, Mtisunge Kachingwe, Isaac Mbingwani, Annie Kalibwe Mkandawire, Hampus Sjöstedt, Wezzie Kumwenda-Mwafulirwa, Surenthirakumaran Rajendra, Odala Kamandani Dzinjalamala   +26 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Point of care ultrasonography of quadriceps femoris muscle thickness for assessing nutritional status in critically ill children

Scientific Reports
Muscle wasting occurs early during critical illness. It is associated with poor PICU outcomes. Ultrasonography can detect muscle thickness in critically ill children.
Shereen A. Mohamed, Hanan M. Elsawy, Hafez M. Bazaraa, Mohamed H. Ghobashy, Mohamed Abdallah Abd El Megied   +4 more
doaj   +1 more source

“The more you learn, the more you can influence”—learning circles to support citizen science in Parkinson's disease: a pilot study in Sweden

Frontiers in Public Health
IntroductionParkinson's disease (PD) is the fastest growing neurological condition, making it a public health concern. There is still much to be learned about this complex disease, and citizen science–the involvement of the public in scientific research ...
Jamie Linnea Luckhaus, Therese Scott Duncan, Carina Hellqvist, Carina Hellqvist, Sara Riggare   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Identifying risk factors for acute respiratory distress syndrome in critically ill patients: a retrospective study

Frontiers in Medicine
BackgroundAcute respiratory distress syndrome (ARDS) is a life-threatening condition that can develop in critically ill patients. Early identification of risk factors associated with ARDS development is essential for timely intervention and improved ...
Yang Zhou, Congye Li, Shuya Mei, Qiaoyi Xu, Shaojie Qin, Jinhua Feng, Jiemin Wang, Shunpeng Xing, Wei Wang, Feng Li, Quanhong Zhou, Zhengyu He, Yuan Gao, Xiaolin Zhang, Zhiyun Zhang   +14 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Glucose management in critically ill adults: A qualitative study from the experiences of health care providers

Heliyon
Aims and objective: To explain the components and elements of glucose management in critically ill adult patients from the healthcare providers’ experiences. Background: Critically ill adults are highly susceptible to stress-induced hyperglycaemia due to
Miao Huang, Li Yang, Chuanlai Zhang, Xiuni Gan   +3 more
doaj   +1 more source

Chrononutrition in Critical Illness

Nutrition Reviews
Abstract Circadian rhythms in humans are biological rhythms that regulate various physiological processes within a 24-hour time frame. Critical illness can disrupt the circadian rhythm, as can environmental and clinical factors, including altered light exposure, organ replacement therapies, disrupted sleep–wake cycles, noise, continuous ...
Eylul Sagun, Asli Akyol, Cetin Kaymak
openaire   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source