Results 131 to 140 of about 5,549,552 (344)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Does a history of sickle cell disease affect the prescription of morphine? An international, randomised study based on clinical vignettes conducted among emergency physicians

BMJ Open
Objectives To assess whether emergency physicians prescribe morphine differently for patients with or without sickle cell disease (SCD). Given the difficulty of comparing strictly homogeneous patients in real clinical settings, we used a standardised ...
Francois-Xavier Ageron, Florence Dupriez, Gregory Yates, Fabien Coisy, Xavier Bobbia, Alexandre Simon, Céline Occelli, Lorie N’Diaye, Anne-Laure Feral-Pierssens   +8 more
doaj   +1 more source

Short- and long-term mortality prediction in critically ill subjects: a cohort study [PDF]

, 2020
Szymon Czajka, Katarzyna Ziębińska, Konstanty Marczenko, Barbara Posmyk, Anna Szczepańska, Łukasz Krzych   +5 more
openalex   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Nutrition intake in critically ill patients with coronavirus disease (COVID-19): A nationwide, multicentre, observational study in Argentina [PDF]

, 2023
Sebastián Chapela, William Manzanares, Eliana Quesada, María Jimena Reberendo, Fernando Baccaro, Irina Aversa, Claudia Kecskes, Lorena Magnífico, Victoria González, Daniela Bolzicco, Nancy Baraglia, Priscila Navarrete, Ezequiel Manrique, María Fernanda Cascarón, Ailen Dietrich, Jesica Asparch, Leticia Betiana Peralta, Cayetano Galletti, Maria Capria, Yamila Lombi, Marian Cecilia Rodriguez, Camila Ester Luna, Andrés Martinuzzi   +22 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

“The more you learn, the more you can influence”—learning circles to support citizen science in Parkinson's disease: a pilot study in Sweden

Frontiers in Public Health
IntroductionParkinson's disease (PD) is the fastest growing neurological condition, making it a public health concern. There is still much to be learned about this complex disease, and citizen science–the involvement of the public in scientific research ...
Jamie Linnea Luckhaus, Therese Scott Duncan, Carina Hellqvist, Carina Hellqvist, Sara Riggare   +4 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Point of care ultrasonography of quadriceps femoris muscle thickness for assessing nutritional status in critically ill children

Scientific Reports
Muscle wasting occurs early during critical illness. It is associated with poor PICU outcomes. Ultrasonography can detect muscle thickness in critically ill children.
Shereen A. Mohamed, Hanan M. Elsawy, Hafez M. Bazaraa, Mohamed H. Ghobashy, Mohamed Abdallah Abd El Megied   +4 more
doaj   +1 more source

Hospital burden of critical illness across global settings: a point prevalence and cohort study in Malawi, Sri Lanka and Sweden

BMJ Global Health
Introduction The burden of critical illness may have been underestimated. Previous analyses have used data from intensive care units (ICUs) only, and there is a lack of evidence about where in hospitals critically ill patients receive care.
Abi Beane, Rashan Haniffa, Martin Gerdin Wärnberg, Lisa Kurland, Tim Baker, Kwazizira Samson Mndolo, Cecilia Stalsby Lundborg, Miklos Lipcsey, Carl Otto Schell, Andreas Wellhagen, Anna Hvarfner, Markus Castegren, Petronella Bjurling-Sjöberg, Raphael Kazidule Kayambankadzanja,, Chamira Kodippily, Grace Banda, Nalayini Jegathesan, Christoffer Hintze, Wageesha Wijesiriwardana, Jayasingha Arachchilage Sujeewa, Mtisunge Kachingwe, Isaac Mbingwani, Annie Kalibwe Mkandawire, Hampus Sjöstedt, Wezzie Kumwenda-Mwafulirwa, Surenthirakumaran Rajendra, Odala Kamandani Dzinjalamala   +26 more
doaj   +1 more source