Results 161 to 170 of about 6,755,416 (402)

Measuring Cardiac Output in the Critically Ill [PDF]

, 2014
__Abstract__ Haemodynamic monitoring plays an essential part on the care of the critically ill patient. Monitoring has two goals; the first goal is a signalling function if the patients clinical condition improves or deteriorates adequate measures can
Slagt, C. (Cornelis)
core  

Comparative evaluation of pulse contour analysis, thermodilution and partial CO(2 )rebreathing techniques for cardiac output assessment in critically ill patients during different levels of positive end expiratory pressure [PDF]

, 2006
Markus Reindl, C. Georgi, Sems‐Malte Tugtekin, Utz Kappert, Klaus Matschke   +4 more
openalex   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Family meetings and end-of-life decision-making in Thai critically ill patients [PDF]

, 2012
Phornlert Chatrkaw, Ratapum Champunot, W Riyakul   +2 more
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

The influence of patients infected with H1N1 influenza A virus on acute kidney injury

Linchuang shenzangbing zazhi, 2017
Objective To retrospectively review the clinical characteristics of severe and critically ill patients infected with 2009 pandemic influenza A(H1N1) virus,and analyze the factors associated with acute kidney injury(AKI) in HlNl-infected patients.Methods ...
LI Rui Ying-xin, LI Ying-xin
doaj  

Point of care ultrasonography of quadriceps femoris muscle thickness for assessing nutritional status in critically ill children

Scientific Reports
Muscle wasting occurs early during critical illness. It is associated with poor PICU outcomes. Ultrasonography can detect muscle thickness in critically ill children.
Shereen A. Mohamed, Hanan M. Elsawy, Hafez M. Bazaraa, Mohamed H. Ghobashy, Mohamed Abdallah Abd El Megied   +4 more
doaj   +1 more source

Population pharmacokinetics of intravenous daptomycin in critically ill patients: implications for selection of dosage regimens

Frontiers in Pharmacology
Daptomycin is gaining prominence for the treatment of methicillin-resistant Staphylococcus aureus infections. However, the dosage selection for daptomycin in critically ill patients remains uncertain, especially in Chinese patients.
Jianhua Wu, Xiangyi Zheng, Liu Zhang, Jiajun Wang, Yifei Lv, Yujie Xi, Dongfang Wu   +6 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source