Results 71 to 80 of about 743,928 (343)
Enhanced protein-energy provision via the enteral route in critically ill patients (PEP uP protocol): a review of evidence [PDF]
, 2016 Nutrition support is an integral part of care among critically ill patients. However, critically ill patients are commonly underfed, leading to consequences such as increased length of hospital and intensive care unit stay, time on mechanical ventilation,
Heyland, Daren K. +3 more
core +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Dependency in Critically Ill Patients
Global Qualitative Nursing Research, 2016 By necessity, critically ill patients admitted to intensive care units (ICUs) have a high level of dependency, which is linked to a variety of negative feelings, such as powerlessness.
Rumei Yang
doaj +1 more source
The lower respiratory tract microbiome of critically ill patients with COVID-19
Scientific Reports, 2021 COVID-19 infection may predispose to secondary bacterial infection which is associated with poor clinical outcome especially among critically ill patients.
Paolo Gaibani +12 more
doaj +1 more source
The microbiome and critical illness [PDF]
The Lancet Respiratory Medicine, 2016 The central role of the microbiome in critical illness is supported by a half century of experimental and clinical study. The physiological effects of critical illness and the clinical interventions of intensive care substantially alter the microbiome.
openaire +3 more sources
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Transfusion thresholds and beyond [PDF]
, 2016 Comment on Liberal transfusion strategy improves survival in perioperative but not in critically ill patients. A meta-analysis of randomised trials.
Biancofiore, G +5 more
core +1 more source
TRANSFUSION TRIGGERS IN CRITICALLY ILL PATIENTS
Pakistan Armed Forces Medical Journal, 2019 Objective: To determine the frequency of inappropriate transfusions in tertiary care hospital. Study Design: Cross sectional study. Place and Duration of Study: General Intensive Care Unit (ICU) Lady Reading Hospital Peshawar, from Dec 2017 to Feb ...
Aisha Kulsoom Mufti
doaj
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source