Results 81 to 90 of about 5,449,919 (359)

AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.

open access: yesJournal of the American Society of Nephrology, 2020
BACKGROUND AKI is a common sequela of coronavirus disease 2019 (COVID-19). However, few studies have focused on AKI treated with RRT (AKI-RRT). METHODS We conducted a multicenter cohort study of 3099 critically ill adults with COVID-19 admitted to ...
Shruti Gupta   +47 more
semanticscholar   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Fluid overload: clinical outcomes in pediatric intensive care unit

open access: yesJornal de Pediatria, 2023
Objective: The aim of this study was to analyze the effects of fluid overload related to mechanical ventilation, renal replacement therapy, and evolution to discharge or death in critically ill children.
Romina Aparecida dos Santos Gomes   +7 more
doaj  

Management of pneumonia in critically ill patients

open access: yesBritish medical journal, 2021
Severe pneumonia is associated with high mortality (short and long term), as well as pulmonary and extrapulmonary complications. Appropriate diagnosis and early initiation of adequate antimicrobial treatment for severe pneumonia are crucial in improving ...
C. Cillóniz, A. Torres, M. Niederman
semanticscholar   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Needs of Parents in Critically Ill Infants Care in the Neonatal Intensive Care Unit (NICU) [PDF]

open access: yes, 2018
Infants hospitalization in the neonatal intensive care unit adversely affect for infants and parents. Efforts that can be developed to minimize the negative impact is by applying family centered care. The first step is to identify needs of parents.
Fatimah, S. (Sari)   +4 more
core  

Intensive versus conventional glucose control in critically ill patients.

open access: yesNew England Journal of Medicine, 2009
BACKGROUND The optimal target range for blood glucose in critically ill patients remains unclear. METHODS Within 24 hours after admission to an intensive care unit (ICU), adults who were expected to require treatment in the ICU on 3 or more consecutive
S. Finfer   +20 more
semanticscholar   +1 more source

Ventilator-associated pneumonia in critically ill patients with COVID-19

open access: yesCritical Care, 2021
Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit (ICU) for invasive ventilation and are at ...
Mailis Maes   +21 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

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