Results 81 to 90 of about 743,928 (343)

Comparison of Serum Vitamin D Status in Critically ill and Non-critically ill Children and its Relationship with Illness Severity and Clinical Outcomes: A Case–Control Study

International Journal of Medicine and Health Development
Background: The role of vitamin D in immune function is well-established in adults, but remains unclear in children. Objectives: We aimed to determine the prevalence of vitamin D deficiency in critically ill versus non-critically ill children and the ...
Eziamaka J. Enemuo, Herbert A. Obu, Ifeyinwa D. Nnakenyi   +2 more
doaj   +1 more source

Feasibility of myocardial perfusion assessment with contrast echocardiography: can it improve recognition of significant coronary artery disease in the ICU?

Critical Care, 2019
Background Diagnosis of significant coronary artery disease (CAD) and acute coronary artery occlusion in ICU can be difficult, and an inappropriate intervention is potentially harmful.
Sam Orde, Michel Slama, Faraz Pathan, Stephen Huang, Anthony Mclean   +4 more
doaj   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Delirium management in critically ill patients [PDF]

, 2013
Delirium among critically ill patients is common. Presence of delirium imparts a poorer prognosis to patients, including longer ICU and hospital length of stay, increased risk of institutionalization, higher health related costs, and elevated mortality ...
Calvo-Ayala, Enrique, Khan, Babar
core   +1 more source

Heat and moisture exchangers (HMEs) and heated humidifiers (HHs) in adult critically ill patients: a systematic review, meta-analysis and meta-regression of randomized controlled trials [PDF]

, 2017
The aims of this systematic review and meta-analysis of randomized controlled trials are to evaluate the effects of active heated humidifiers (HHs) and moisture exchangers (HMEs) in preventing artificial airway occlusion and pneumonia, and on mortality ...
A Boyer, A Kola, A Tonnelier, A Verta, Antonio M. Esquinas, AW Thille, B Bissonette, B Bissonnette, B Misset, C Girault, C Martin, C Martin, C Martin, C Martin, D Dreyfuss, Davide Chiumello, DR Hess, E Schena, E Schena, E Schena, E Schena, F Lellouche, F Lellouche, F Lellouche, G Bourdelles Le, G Conti, G Prat, GA Iotti, Giuseppe Servillo, H Deriaz, H Schiffmann, I Morán, II Siempos, IL Cohen, J Hurni, J Rathgeber, J Rathgeber, J Retamal, JC Lacherade, JD Ricard, JL Peters, JM Alonso-Iñigo, JM Wilmshurst, JP Roustan, K Linko, L Kirkegaard, L Lorente, L Lorente, L Thomachot, L Thomachot, Lorenzo Ball, M Dixon-Woods, M Luchetti, M Luchetti, Maria Vargas, MC Villafane, MD Dias, MD Dias, ME Goldberg, MH Kollef, MT McEvoy, N Denzin, NK Nakagawa, NR MacIntyre, O Kirton, P Pelosi, PA Johnson, Paolo Pelosi, R Arieli, R Boots, R Kranabetter, R MacLeod, RB Diaz, RD Branson, RD Branson, RD Branson, RD Branson, RD Restrepo, RJ Boots, RS Campbell, S Bench, S Christiansen, S Ehrmann, S Jaber, S Oguz, S Prin, Y Fujita, Y Takumi, Yuda Sutherasan, ZA Memish   +89 more
core   +3 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Serum Procalcitonin Level and Mortality Risk in Critically ill Patients with Ventilator-Associated Pneumonia

Cellular Physiology and Biochemistry, 2015
Background/Aims: The prognostic role of serum procalcitonin level in critically ill patients with ventilator-associated pneumonia was unclear. The aim of our study was to investigate the relationship between serum procalcitonin level and mortality risk ...
Bo Li, Xin Zhao, Shumei Li
doaj   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Levosimendan in critical illness: A literature review [PDF]

, 2014
Levosimendan, the active enantiomer of simendan, is a calcium sensitizer developed for treatment of decompensated heart failure, exerts its effects independently of the beta adrenergic receptor and seems beneficial in cases of severe, intractable heart ...
Franchi, Federico, Karanikolas, Menelaos, Muzzi, Luigi, Pierrakos, Charalampos, Scolletta, Sabino, Velissaris, Dimitrios   +5 more
core   +2 more sources