Results 81 to 90 of about 5,549,552 (344)

Glycemic control in critically 111: A review

open access: yesJournal of Pediatric Critical Care, 2017
Dysglycemia is frequently encountered in critically ill patients in the intensive care units (ICU) and is associated with increased morbidity and mortality.
Preeti Anand   +2 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Thromboelastography Parameters as Predictors for Long-Term Survival in Critically Ill Patients

open access: yesClinical and Applied Thrombosis/Hemostasis, 2019
Thromboelastography (TEG) is used for monitoring abnormal blood coagulation in critically ill patients. However, the correlation between TEG parameters and long-term survival in these patients is unknown.
Cuizhu Luo MS   +2 more
doaj   +1 more source

Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study

open access: yesIntensive Care Medicine, 2020
Purpose To describe acute respiratory distress syndrome (ARDS) severity, ventilation management, and the outcomes of ICU patients with laboratory-confirmed COVID-19 and to determine risk factors of 90-day mortality post-ICU admission.
Matthieu David Alexandre Tài Alain Martin Said Antoine Alai Schmidt Hajage Demoule Pham Combes Dres Lebbah Kim   +499 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Feasibility of myocardial perfusion assessment with contrast echocardiography: can it improve recognition of significant coronary artery disease in the ICU?

open access: yesCritical Care, 2019
Background Diagnosis of significant coronary artery disease (CAD) and acute coronary artery occlusion in ICU can be difficult, and an inappropriate intervention is potentially harmful.
Sam Orde   +4 more
doaj   +1 more source

Covid-19: FDA approves use of convalescent plasma to treat critically ill patients

open access: yesBritish medical journal, 2020
The US Food and Drug Administration has approved the use of plasma from recovered patients to treat people who are critically ill with covid-19, provided that doctors get approval over the telephone.1 The method has been used in the past to treat ...
J. Tanne
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Dependency in Critically Ill Patients

open access: yesGlobal Qualitative Nursing Research, 2016
By necessity, critically ill patients admitted to intensive care units (ICUs) have a high level of dependency, which is linked to a variety of negative feelings, such as powerlessness.
Rumei Yang
doaj   +1 more source

Serum Procalcitonin Level and Mortality Risk in Critically ill Patients with Ventilator-Associated Pneumonia

open access: yesCellular Physiology and Biochemistry, 2015
Background/Aims: The prognostic role of serum procalcitonin level in critically ill patients with ventilator-associated pneumonia was unclear. The aim of our study was to investigate the relationship between serum procalcitonin level and mortality risk ...
Bo Li, Xin Zhao, Shumei Li
doaj   +1 more source

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