Results 181 to 190 of about 1,231,981 (407)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Therapeutic evaluation of prolonged infusions of β-lactam antibiotics in the treatment and management of critically ill patients [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2017
Context: Critically ill patients has a large number of pathophysiological changes product of commitment and organ systems. Therefore, knowledge of the pharmacological properties of antimicrobials is essential to choose the best treatment.
Jorge S. Amador, Juan P. Carrasco, Álvaro A. Morales, Claudia P. Cortes   +3 more
doaj  

Risk factors for Candida colonization/infection in non-neutropenic medical critically ill patients [PDF]

, 2001
Joan M. Nolla, Carlos F. Mendes de Leon, R. Jordà, MA León, MJ Pontes, María Isabel Morales‐Casado   +5 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

FP069ROLE OF SOLUBLE FORM AND EXTRACELLULAR VESICLE (EV)-CARRIED CD40LIGAND (CD40L) AS BIOMARKER OF DISEASE ACTIVITY AND AS MEDIATOR OF MICROVASCULAR ENDOTHELIAL INJURY IN CRITICALLY ILL PATIENTS WITH ACUTE KIDNEY INJURY (AKI) AND IN END STAGE RENAL DISEASE (ESRD) PATIENTS [PDF]

, 2018
Marita Marengo, M. Migliori, Davide Medica, Vincenzo Panichi, Claudio Ronco, Vincenzo Cantaluppi   +5 more
openalex   +1 more source

Acute renal failure in critically ill patients: a multinational, multicenter study.

Journal of the American Medical Association (JAMA), 2005
S. Uchino, J. Kellum, R. Bellomo, G. Doig, H. Morimatsu, S. Morgera, M. Schetz, I. Tan, C. Bouman, Ettiene Macedo, N. Gibney, A. Tolwani, C. Ronco   +12 more
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Prevalence of invasive fungal infection in critically Ill patients: a systematic review and meta-analysis

BMC Infectious Diseases
Background Invasive fungal infections (IFI) contribute significantly to morbidity and mortality among critically ill patients, particularly in intensive care units (ICUs). Accurate prevalence estimates are essential to inform clinical strategies.
Mauricio Trelles, José Murillo, Luis Fuenmayor-González, Yunqi Yu-Liu, Harold Alexander-León, Joanna Acebo, Diego Cuicapuza, Marco Morales, Christopher Peña, María Fernanda García-Aguilera   +9 more
doaj   +1 more source

Intensive versus conventional glucose control in critically ill patients.

New England Journal of Medicine, 2009
S. Finfer, D. Chittock, S. Su, Deborah Blair, D. Foster, V. Dhingra, R. Bellomo, D. Cook, P. Dodek, W. Henderson, P. Hebert, S. Heritier, D. Heyland, C. McArthur, E. McDonald, I. Mitchell, J. Myburgh, R. Norton, Julie Potter, Bruce G. Robinson, J. Ronco   +20 more
semanticscholar   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source