Early Phase Dose‐Finding Designs for CAR‐T Cell Therapies
ABSTRACT Chimeric Antigen Receptor (CAR)‐T cell is an immunotherapy which revolutionised the treatment of relapsed/refractory lymphoma and leukaemia. It is shown to have a higher response rate, higher mid‐to‐long term overall survival, and lower toxicity than standard treatments.
Weishi Chen +3 more
wiley +1 more source
Allostatic load and progression of cardio-renal multimorbidity: A UK biobank study. [PDF]
Zhu Q, Xu L, Fan Z, Li H.
europepmc +1 more source
Utilization of Thermally Modified Water Treatment Plant Sludge as an Adsorbent for Fluoride Removal
ABSTRACT The presence of fluoride (F−) at high concentrations in drinking water is a global concern due to its adverse health effects. This study evaluated the removal of F− ions by adsorption using an adsorbent produced from thermally modified water treatment plant sludge (TWTPS), providing an efficient and low‐cost alternative for contaminated water ...
Kellen Cristina da Silva Almeida +3 more
wiley +1 more source
The Role of the Mesopancreas in Pancreatic Neuroendocrine Neoplasms. [PDF]
David SO +6 more
europepmc +1 more source
This study investigated how species richness and biotope space affect phytoextracted nickel mass. Growing monocultures and bicultures of two endemic species across a nickel stress gradient revealed that bicultures generally enhanced soil nickel bioavailability, aboveground biomass, and nickel phytoextraction compared to monocultures.
Panayiotis G. Dimitrakopoulos +3 more
wiley +1 more source
Propensity score matched analysis of short-term outcomes in rectal cancer robotic surgery: Hugo RAS versus da Vinci systems. [PDF]
Toda S +8 more
europepmc +1 more source
ABSTRACT Yellowfin sole (Limanda aspera) support the largest flatfish fishery in the world and contribute substantially to the eastern Bering Sea (EBS) flatfish catch. The EBS has been warming and acidifying, trends that are expected to intensify into the future.
Emily Slesinger +5 more
wiley +1 more source
Multi-perspective views about healthcare experiences for those with incurable head and neck cancer: A prospective, longitudinal, qualitative study. [PDF]
Mayland CR +7 more
europepmc +1 more source
Enhanced Biomethane Recovery From Source‐Separated Cow Urine via Co‐Digestion With Waste Paper
This study outlines the experimental process where cow urine, collected from a dairy barn equipped with a source‐separating manure system, and waste paper are loaded into bioreactors (CU0–CU50) at varying ratios to analyze the biogas yield. The analytical results highlight that this collection system significantly enhances biogas and biomethane ...
Busra Kabay, Unal Sirin
wiley +1 more source
Use of the GSK MenACWY-CRM/MenB-4C Pentavalent Meningococcal Vaccine Among Persons Aged ≥10 Years: Recommendations of the Advisory Committee on Immunization Practices - United States, 2025. [PDF]
Amin AB +6 more
europepmc +1 more source

