Results 151 to 160 of about 2,009 (183)

Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain. [PDF]

Pain
Gomez K, Allen HN, Duran P, Loya-Lopez S, Calderon-Rivera A, Moutal A, Tang C, Nelson TS, Perez-Miller S, Khanna R.   +9 more
europepmc   +1 more source

The Human Lens Fiber Cytoskeletome Reveals Neuronal Signatures and the Presence of Chaperonins, Proteasome, Signaling, and Redox Regulators. [PDF]

Invest Ophthalmol Vis Sci
Maddala R, Lankford LK, Skiba NP, Rao PV.   +3 more
europepmc   +1 more source

Evaluation of an indirect Na_V1.7 inhibitor as adjunctive analgesic in burn-related neuropathic pain in a cat. [PDF]

Vet Anaesth Analg
Chiavaccini L, Santoro D, Dwyer CE, Vettorato E, Nelson TS, Khanna R.   +5 more
europepmc   +1 more source

Intranasal CRMP2-Ubc9 inhibitor regulates Na V 1.7 to alleviate trigeminal neuropathic pain. [PDF]

Pain
Loya-Lopez SI, Allen HN, Duran P, Calderon-Rivera A, Gomez K, Kumar U, Shields R, Zeng R, Dwivedi A, Saurabh S, Korczeniewska OA, Khanna R.   +11 more
europepmc   +1 more source

The Duality of Cdk5: A Master Regulator in Neurodevelopment and a Hijacked Oncogene in Cancer. [PDF]

Cells
Nishimura YV, Kawauchi T.
europepmc   +1 more source

Decoding orofacial pain: a translational review of mechanisms and novel therapies. [PDF]

J Headache Pain
Kang Y, Fu Y, Jian K, Liu J, Shao L.
europepmc   +1 more source

Quercetin attenuated ischemic stroke induced neurodegeneration by modulating glutamatergic and synaptic signaling pathways.

Heliyon
Shah FA, Albaqami F, Alattar A, Alshaman R, Zaitone SA, Gabr AM, Abdel-Moneim AH, Dosoky ME, Koh PO.   +8 more
europepmc   +1 more source

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels [PDF]

Channels, 2018
Drug discovery campaigns directly targeting the voltage-gated sodium channel NaV1.7, a highly prized target in chronic pain, have not yet been clinically successful. In a differentiated approach, we demonstrated allosteric control of trafficking and activity of NaV1.7 by prevention of SUMOylation of collapsin response mediator protein 2 (CRMP2). Spinal
Liberty Francois-Moutal, David Donald Scott, Samantha Perez-Miller   +2 more
exaly   +4 more sources

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission [PDF]

Molecular Neurobiology, 2018
The collapsin response mediator protein 2 (CRMP2) has emerged as a central node in assembling nociceptive signaling complexes involving voltage-gated ion channels. Concerted actions of post-translational modifications, phosphorylation and SUMOylation, of CRMP2 contribute to regulation of pathological pain states.
Aubin Moutal, Angie Dorame, Shreya S Bellampalli   +2 more
exaly   +3 more sources

CRMP2 Protein SUMOylation Modulates NaV1.7 Channel Trafficking [PDF]

Journal of Biological Chemistry, 2013
Voltage-gated sodium channel (NaV) trafficking is incompletely understood. Post-translational modifications of NaVs and/or auxiliary subunits and protein-protein interactions have been posited as NaV-trafficking mechanisms. Here, we tested if modification of the axonal collapsin response mediator protein 2 (CRMP2) by a small ubiquitin-like modifier ...
Erik T Dustrude, Sarah M Wilson, Weina Ju   +2 more
exaly   +3 more sources