Results 161 to 170 of about 2,009 (183)
CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation [PDF]
Molecular Neurobiology, 2017 Glioblastoma (GBM) is an aggressive primary brain tumor. The rapid growth and the privileged provenance of the tumor within the brain contribute to its aggressivity and poor therapeutic targeting. A poor prognostic factor in glioblastoma is the deletion or mutation of the Nf1 gene.
Aubin Moutal +2 more
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Druggability of CRMP2 for Neurodegenerative Diseases
ACS Chemical Neuroscience, 2020Collapsin response mediator proteins (CRMPs) are ubiquitously expressed phosphoproteins that coordinate cytoskeletal formation and regulate cellular division, migration, polarity, and synaptic connection. CRMP2, the most studied of the five family members, is best known for its affinity for tubulin heterodimers and function in regulating the ...
Rajesh Khanna +5 more
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Coordinating Synaptic Signaling with CRMP2
The International Journal of Biochemistry & Cell Biology, 2020Synaptic transmission is a complex process, dysregulation of which underlies several neurological conditions. Collapsin response mediator protein 2 (CRMP2) is a microtubule associated protein expressed ubiquitously in the central nervous system. Identified initially in the context of Semaphorin 3A (Collapsin) induced growth cone collapse, more recent ...
Harrison Stratton +3 more
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Neurochemical Research, 2013
Collapsin response mediator protein 2 (CRMP2) is a brain-specific multifunctional adaptor protein involved in neuronal polarity and axonal guidance. Our previous results showed CRMP2 may be involved in the hypoxic preconditioning and ischemic injury, but the mechanism was not clear.
Yanling Yin, Song Han, Yanlin Luo
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Collapsin response mediator protein 2 (CRMP2) is a brain-specific multifunctional adaptor protein involved in neuronal polarity and axonal guidance. Our previous results showed CRMP2 may be involved in the hypoxic preconditioning and ischemic injury, but the mechanism was not clear.
Yanling Yin, Song Han, Yanlin Luo
exaly +3 more sources
SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons [PDF]
Channels, 2013 The axon/dendrite specification collapsin response mediator protein 2 (CRMP2) bidirectionally modulates N-type voltage-gated Ca ( 2+) channels (CaV2.2). Here we demonstrate that small ubiquitin-like modifier (SUMO) protein modifies CRMP2 via the SUMO E2-conjugating enzyme Ubc9 in vivo. Removal of a SUMO conjugation site KMD in CRMP2 (K374A/M375A/D376A;
Weina Ju +2 more
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Phosphorylation and SUMOylation of CRMP2 regulate the formation and maturation of dendritic spines
Brain Research Bulletin, 2018 The posttranslational modifications of CRMP2 play an important role in axon outgrowth, cell polarization and dendritic morphogenesis. However, whether CRMP2 and its posttranslational modifications are involved in dendritic spine development specifically is not completely clear.
Jifeng Zhang, Bo Zhao, Jiong Li
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A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function [PDF]
Channels, 2017 The neuronal collapsin response mediator protein 2 (CRMP2) undergoes several posttranslational modifications that codify its functions. Most recently, CRMP2 SUMOylation (addition of small ubiquitin like modifier (SUMO)) was identified as a key regulatory step within a modification program that codes for CRMP2 interaction with, and trafficking of ...
Erik T Dustrude +2 more
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Ketamine Regulates Phosphorylation of CRMP2 To Mediate Dendritic Spine Plasticity
Journal of Molecular Neuroscience, 2019Ketamine is widely used in infants and young children for anesthesia, and subanesthetic doses of ketamine make neurons form new protrusions and promote synapse formation. However, the precise pathological mechanisms remain to be elucidated. In this study, we demonstrated that ketamine administration significantly increased dendritic spine density and ...
Zhongqi Zhang +6 more
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Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency
Neuroscience Research, 2019Pyridoxal, an active form of vitamin B6, is known to inhibit formation of advanced glycation end-products and protect tissues from diabetic complications. Here we identified that pyridoxal is a required component for establishing Schwann cell myelination in our Schwann cell-dorsal root ganglion neuron co-culture system.
Fuminori Saitoh +3 more
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Inhibition of Ubc9-Induced CRMP2 SUMOylation Disrupts Glioblastoma Cell Proliferation
Journal of Molecular Neuroscience, 2019Glioblastoma (GBM) is the most aggressive astrocytoma. Despite maximum treatment, the GBM usually recurs and the patient survival is poor. Thus, understanding the molecular mechanism of GBM progression will be meaningful to ameliorate this situation. In this study, collapsin response mediator protein 2 (CRMP2) and Ubc9 protein levels were evaluated in ...
Suzhen Ji
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