Results 21 to 30 of about 4,371 (179)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Biologically active compounds of bioresidues of Crocus Sativus flower [PDF]

E3S Web of Conferences
Secondary metabolites present in Crocus sativus L. petals (saffron) grown in Uzbekistan, were studied for the first time. According to the results of phytochemical studies, it was observed that biowaste contains a large amount of biologically active ...
Narbutaeva Dildora, Makhmudova Shokhista, Keneshov Bakyt, Okhundedaev Bakhodir, Nishanbaev Sabir   +4 more
doaj   +1 more source

Multi‐Induction Strategies in Crops: Mechanisms, Synergistic Effects, and Sustainable Applications for Enhanced Secondary Metabolite Production

Food Frontiers, Volume 7, Issue 4, July 2026.
This review analyzes single/combined abiotic (light, water, nutrients, hormones) and biotic (microbes, yeast) elicitors regulating signaling, gene expression, and metabolism to boost plant secondary metabolites. It highlights synergistic multielicitor strategies for crop quality and functional foods, while critically addressing current limitations and ...
Yifei Sun, Daoyan Xiao, Xingyue Li, Zhaofei Wang, Maoqin Xia, Chao Song, Hong‐Lei Li   +6 more
wiley   +1 more source

Effects of Crocus sativus on glycemic control and cardiometabolic parameters among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

Nutrition & Metabolism
Metabolic syndrome (MetS) is a cluster of clinical syndromes that is closely associated with an elevated risk of developing atherosclerotic cardiovascular disease.
Xiaodan Yan, Shuyuan Zhao, Xue Feng, Xinrui Li, Qian Zhou, Qiu Chen   +5 more
doaj   +1 more source

A novel use of purple tulip petal anthocyanins in pH‐sensitive polyvinyl alcohol films for the real‐time monitoring of shrimp freshness

Journal of the Science of Food and Agriculture, Volume 106, Issue 9, Page 5549-5562, July 2026.
Abstract BACKGROUND Shrimp is among the most perishable seafood commodities, and its freshness is still largely assessed through time‐consuming laboratory methods. pH‐responsive colorimetric films have received growing attention as they allow visual, real‐time quality monitoring without specialized equipment.
Tuncay Gümüş, Yasemin Henden, D. Damla Altan Kamer   +2 more
wiley   +1 more source

Gallic Acid‐Mediated Enhancement of Diazepam‐Induced Sedation via GABAA Receptor Modulation: In Vivo and In Silico Evaluation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Gallic acid (GA) dose‐dependently reduced sleep latency and prolonged sleep duration in thiopental sodium‐induced mice, with synergistic effects when combined with diazepam. Molecular docking revealed GA's higher binding affinity (−9.8 kcal/mol) to GABAA receptor (α1 and β2 subunits) than diazepam (−8.4 kcal/mol), suggesting GABAergic potential ...
Noshin Tasnim Yana, Anike Chakrabarty, Chinmoy Kumar Saha, Nikhat Jamal Siddiqi, Norah Alnazhan, Md. Sakib Al Hasan, Feroz Khan Nun, Imam Hossen Rakib, Md. Nasimul Haque Shipon, Emon Mia, Md Asaduzzaman Jony, Ali Mohamod Wasaf Hasan, Muhammad Torequl Islam, Azmat Ali Khan   +13 more
wiley   +1 more source

Impact of Moroccan Crocus sativus L. tepals, corms, and stigmas extract on growth and photosynthetic pigments in tomato seedling

Advances in Horticultural Science, 2021
An experiment was carried out in a greenhouse to study the effect of aqueous extracts of Crocus sativus L. by-products on tomato plants. Three concentrations of tepals and corms were used by fertigation: 1 g/L, 2 g/L, and 3 g/L.
Amine Khoulati, E. Saalaoui
doaj   +1 more source

Short‐Term, Cycle‐Synchronized Adjunctive Therapy With Crocus Total Glucosides Tablets for Cardiac Protection Against Cancer Therapy‐Related Cardiac Dysfunction in Breast Cancer Patients: A Randomized, Double‐Blind, Placebo‐Controlled Trial

MedComm, Volume 7, Issue 6, June 2026.
Cycle‐synchronized CTGT therapy attenuates LVGLS decline and reduces CTRCD in breast cancer patients. This randomized, double‐blind, placebo‐controlled trial assessed whether cycle‐synchronized CTGT prevent CTRCD in 120 breast cancer patients receiving chemotherapy.
Xiaoling Liu, Mengmeng Li, Wenwen Song, Yu Zhang, Wuyun Bao, Chaoyu Liu, Yuan Zhang, Quande Liu, Cheng Zhang, Yun Zhang, Li Li, Mei Zhang   +11 more
wiley   +1 more source

Petal and Stigma of Crocus sativus L. in the Treatment of Depression: A Pilot Double - blind Randomized Trial

Journal of Medicinal Plants, 2008
Stigma of Crocus sativus L. (Iridaceae), commonly known as saffron, is the world’s most expensive spice and apart from its traditional value as food additive recent studies indicate its potential as antidepressant.
A Akhondzadeh Basti, SA Ghoreishi, AA Noorbala, SH Akhondzadeh, Sh Rezazadeh   +4 more
doaj  

Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L.

Pharmaceuticals, 2022
Psychotropic effect of Crocus sativus L. (family Iridaceae) biologically active chemical compounds are quite well documented and they can therefore be used in addition to the conventional pharmacological treatment of depression. This systematic review on
Renata Matraszek-Gawron, Mirosława Chwil, Karol Terlecki, Michał Marian Skoczylas   +3 more
doaj   +1 more source