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Nature Reviews Disease Primers, 2020 Crohn's disease is an inflammatory bowel disease that is characterized by chronic inflammation of any part of the gastrointestinal tract, has a progressive and destructive course and is increasing in incidence worldwide. Several factors have been implicated in the cause of Crohn's disease, including a dysregulated immune system, an altered microbiota ...
G. Roda +8 more
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Ileal and colonic Crohn's disease: Does location makes a difference in therapy efficacy?
Current Research in Pharmacology and Drug Discovery, 2022 Within the IBD entity of Crohn's disease, there is currently no differentiation between ileal and colonic manifestation for recruitment of patients in clinical trials, well-powered analysis of study results or therapeutic decisions in daily clinical ...
Raja Atreya +5 more
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Crohn's disease what we know about it, symptoms, diagnosis, treatment
Journal of Education, Health and Sport, 2023 Crohn's disease is a chronic disease. It most often begins between the ages of 15 and 35 and lasts a lifetime. The earliest radiographic findings are aphthous ulcers. It can cause mouth-to-anal lesions and extra-intestinal complications. Typical symptoms
Monika Sosna +2 more
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Knife cut fissures: A clue for vulval crohn's disease!!
Clinical Dermatology Review, 2021 Crohn's disease is an inflammatory bowel disorder with various extraintestinal manifestations. Vulva is rarely involved in Crohn's disease and occasionally may constitute the only sign of the disease.
M L Ranjitha +3 more
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Crohn's disease - diagnosis and treatment
Journal of Education, Health and Sport, 2021 AdmissionCrohn's disease belongs to the group of chronic and still incurable diseases. It has periods of exacerbation and partial or complete remission. It mainly affects young people.
Patrycja Ręba
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Crohn's disease or Crohn's diseases? [PDF]
Gut, 2003 Disease behaviour in Crohn’s disease is dynamic and not stable over time In their landmark paper of 1932, Crohn, Ginzburg, and Oppenheimer1 described “a disease of the terminal ileum, affecting mainly young adults and characterised by a subacute or chronic necrotising and cicratrising inflammation.
Arnott, IDR, Satsangi, J
openaire +4 more sources
Upadacitinib Induction and Maintenance Therapy for Crohn's Disease.
New England Journal of Medicine, 2023 BACKGROUND Upadacitinib, an oral selective Janus kinase (JAK) inhibitor, is under investigation for the treatment of Crohn's disease. METHODS In two phase 3 induction trials (U-EXCEL and U-EXCEED), we randomly assigned patients with moderate-to-severe ...
E. Loftus +18 more
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PLoS ONE, 2021 The burden of inflammatory bowel disease (IBD) in Australia is increasing but national data about the current prevalence are limited. We aimed to estimate the prevalence of IBD (including Crohn's disease, ulcerative colitis and unspecified IBD) as well ...
Doreen Busingye +2 more
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Case Reports in Gastrointestinal Medicine, 2022 Whereas typical Crohn’s disease is confined to the terminal ileum and presents with abdominal pain and diarrhea, gastroduodenal manifestations of Crohn’s disease are rare, with often asymptomatic patient presentations and inconclusive diagnostic testing.
Clive Jude Miranda +4 more
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