Results 31 to 40 of about 4,909,303 (275)

Whole-exome sequencing in a subject with fluctuating neuropsychiatric symptoms, immunoglobulin G1 deficiency, and subsequent development of Crohn’s disease: a case report

Journal of Medical Case Reports, 2022
Background Mutations or polymorphisms of genes that are associated with inflammasome functions are known to predispose individuals to Crohn’s disease and likely affect clinical presentations and responses to therapeutic agents in patients with Crohn’s ...
Harumi Jyonouchi, Lee Geng
doaj   +1 more source

Radiologic images of complications of Crohn's disease

International Journal of Gastrointestinal Intervention, 2023
Crohn's disease is a chronic inflammatory disease that may occur in the alimentary tract and has various clinical courses. It is characterized by several complications, including bowel strictures, bowel obstruction, fistulas, abscesses, and ...
Sungjin Yoon, So Hyun Park, Jun Seong Kim   +2 more
doaj   +1 more source

Crohn disease

Autopsy and Case Reports, 2015
Aretaeus of Cappadocia (1st century CE) described a young man with chronic and recurring abdominal distress possibly representing the first recorded instance of Crohn disease (CD).1-3 More evidence that this disease was extant for many years comes from the description of the 10th century English king, Alfred “the great,” who suffered for many years ...
Stephen A. Geller, Fernando Peixoto Ferraz de Campos   +1 more
openaire   +3 more sources

Common NOD2/CARD15 variants are not associated with susceptibility or the clinicopathologic characteristics of sporadic colorectal cancer in Hungarian patients [PDF]

, 2007
Background: Epidemiological observations suggest that cancer arises from chronically inflamed tissues. Inflammatory bowel disease (IBD) is a typical example as patients with longstanding IBD are at an increased risk for developing colorectal cancer (CRC)
Zinober Kerstin, Kerstin Zinober, Gemela, Orsolya, Veres, Gábor, Peter Ferenci, Fischer, Simon, Orsolya Gemela, Papp, János, Janos Papp, Ferenci Peter, Peter Fuszek, Gemela Orsolya, Szalay Ferenc, Erika Hitre, Osztovits, János, Fischer Simon, Szalay, Ferenc, Fuszek, Péter, Ferenc Szalay, Veres Gabor, Janos Osztovits, Laszlo Lakatos, Zinober, Kerstin, Hitre, Erika, Osztovits Janos, Peter Laszlo Lakatos, Lakatos, Péter László, Hitre Erika, Lakatos Laszlo, Papp Janos, Simon Fischer, Lakatos Peter, Ferenci, Péter, Lakatos, László, Fuszek Peter, Gabor Veres   +35 more
core   +2 more sources

Where are all the Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease?

PLoS Pathogens, 2009
Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic granulomatous inflammation of the intestines, Johne's disease, in dairy cows and every other species of mammal in which it has been identified.
Ellen S Pierce
doaj   +1 more source

Multicentric Cutaneous Crohn's Disease: A Case Report and Review of Literature

Canadian Journal of Gastroenterology, 1990
A patient presented with skin lesions at sites not contiguous with Crohn's disease of the bowel and with specific histological features of Crohn's disease occurring two weeks from the onset of bowel symptoms.
Robert Prokopetz, J Barrie Ross, Peter Smith, Joseph J Sidorov   +3 more
doaj   +1 more source

The association between Crohn's disease activity, serum 25(oh)- vitamin d status, the disease-associated environmental risk factors and the variability of Crohn's disease phenotype in the Western Cape population, South Africa [PDF]

, 2014
Philosophiae Doctor - PhDBackground: A subtype of inflammatory bowel disease, Crohn' s disease is thought to represent a complex interaction between environmental factors, a defective immune system, the gastrointestinal microbiome and genetic ...
Basson, Abigail Raffner
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source