Results 51 to 60 of about 10,538,494 (333)

OC-163 identification of inflammatory bowel disease (IBD) using field asymmetric ion mobility spectrometry (FAIMS) [PDF]

, 2012
Introduction Resident colonic bacteria, principally anaerobes and firmicutes, ferment undigested fibre. The resultant volatile organic compounds (VOCs) formed are dissolved in the faeces but also absorbed and excreted in the urine.
Thomas, M. G., Hetherington, E., Arasaradnam, Ramesh P., Ouaret, N., Covington, James A., Quraishi, M. N., Nwokolo, Chuka U., Bardhan, Karna Dev   +7 more
core   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Abnormal plasma polyunsaturated fatty acid pattern in non-active inflammatory bowel disease

, 1993
An abnormal plasma polyunsaturated fatty acid pattern (PUFA) (increased n3 and decreased n6 PUFA) has been reported in active inflammatory bowel disease (IBD). The possibility of a primary defect in the PUFA metabolism in IBD was hypothesised. The aim of
Esteve i Comas, Maria, Fernández Bañares, Fernando, Abad Lacruz, Agueda, Cabré i Gelada, Eduard, Gassull, Miquel Àngel, Núñez, M. C., González-Huix Lladó, Ferran, Bertrán, X., Gil, Ángel   +8 more
core   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Adalimumab Dose-Escalation Therapy Is Effective in Refractory Crohn’s Disease Patients with Loss of Response to Adalimumab, Especially in Cases without Previous Infliximab Treatment

Case Reports in Gastroenterology, 2019
Background/Aims: Adalimumab dose escalation is one of the most important options in refractory Crohn’s disease patients with loss of response to adalimumab. The goal of this study was to evaluate the effectiveness of adalimumab dose escalation in Crohn’s
Taketo Suzuki, Tsutomu Mizoshita, Tomoya Sugiyama, Yoshikazu Hirata, Yoshihide Kimura, Yuka Suzuki, Tomonori Yamada, Hironobu Tsukamoto, Takashi Mizushima, Naomi Sugimura, Takahito Katano, Satoshi Tanida, Hiromi Kataoka, Makoto Sasaki   +13 more
doaj   +1 more source

Upadacitinib in Patients With Difficult-to-Treat Crohn's Disease [PDF]

Upadacitinib has recently been approved for treating Crohn's disease (CD). Here, we report on the effectiveness and safety of upadacitinib in a cohort of patients with difficult-to-treat CD being cared for at clinical centers across ...
Lorenzo Bertani, Paola Balestrieri, Marzo, Manuela, Soriano, Alessandra, Conforti, Francesco Simone, Cristina Bezzio, Principi, Maria Beatrice, Carolina Cavalli, Savarino, Edoardo V, Angela Variola, Bodini, Giorgia, Alessandro Armuzzi, Casini, Valentina, Armuzzi, Alessandro, Michele Campigotto, Variola, Angela, Silvio Danese, Balestrieri, Paola, Manuela Marzo, Aratari, Annalisa, Barberio, Brigida, Annalisa Aratari, Cavalli, Carolina, Calabrese, Emma, Savarino Edoardo, Cappello, Maria, Andrea Michielan, Danese, Silvio, Maria Cappello, Ceccarelli, Linda, Valentina Casini, Bertani, Lorenzo, Alessandra Soriano, Mauro Mastronardi, Federica Furfaro, Franco Scaldaferri, Giorgia Bodini, Giuseppe Biscaglia, Campigotto, Michele, Emma Calabrese, Linda Ceccarelli, Flavio Andrea Caprioli, Mastronardi, Mauro, Furfaro, Federica, Caprioli, Flavio Andrea, Saibeni, Simone, Franchellucci, Gianluca, Biscaglia, Giuseppe, Michielan, Andrea, Simone Saibeni, Bezzio, Cristina, Francesco Simone Conforti, Scaldaferri, Franco, Maria Beatrice Principi, Gianluca Franchellucci, Barberio Brigida   +55 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Prediction of Perianal Fistula in Crohn’s Disease by Computed Tomography Enterography

The Turkish Journal of Gastroenterology
Background/Aims: The purpose of this study was to investigate whether computed tomography enterography can be used to predict the presence of perianal fistula in Crohn’s disease patients.
Genghuan Ni, Hongwei Zhao, Haiyan Shen, Senjuan Li, Weiqun Ao   +4 more
doaj   +1 more source

Meckel's Diverticulum in Crohn's Disease

Canadian Journal of Gastroenterology, 2001
Meckel's diverticulum is a congenital abnormality of the distal ileum associated with failed vitelline duct closure. Detailed pathological studies have estimated its frequency to be about 2% of the general population, and it has been anecdotally recorded
Hugh J Freeman
doaj   +1 more source