Results 51 to 60 of about 4,909,303 (275)

The role of the NOD2 gene in the pathogenesis of Crohn’s disease [PDF]

, 2009
Introduction: Crohn’s disease is characterised by an abnormal inflammatory response possibly induced by components of enteric bacteria, in genetically susceptible individuals.
Chalmers-Watson, T.A.
core  

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Adalimumab Dose-Escalation Therapy Is Effective in Refractory Crohn’s Disease Patients with Loss of Response to Adalimumab, Especially in Cases without Previous Infliximab Treatment

Case Reports in Gastroenterology, 2019
Background/Aims: Adalimumab dose escalation is one of the most important options in refractory Crohn’s disease patients with loss of response to adalimumab. The goal of this study was to evaluate the effectiveness of adalimumab dose escalation in Crohn’s
Taketo Suzuki, Tsutomu Mizoshita, Tomoya Sugiyama, Yoshikazu Hirata, Yoshihide Kimura, Yuka Suzuki, Tomonori Yamada, Hironobu Tsukamoto, Takashi Mizushima, Naomi Sugimura, Takahito Katano, Satoshi Tanida, Hiromi Kataoka, Makoto Sasaki   +13 more
doaj   +1 more source

Late onset crohns ileitis—A diagnostic dilemma

Journal of Family Medicine and Primary Care, 2022
Crohn's disease may affect individuals across all age groups. Usually, it tends to start at a young age, hence late onset Crohn's disease may be difficult to diagnose.
Ashok Sunder, Manish Kumar, Sudip Saha, Bhagyalakshmi Satyanarayan   +3 more
doaj   +1 more source

Autophagy and Crohn's Disease [PDF]

Journal of Innate Immunity, 2013
Advances in genetics have shed light on the molecular basis of Crohn's disease (CD) predisposition and pathogenesis, via linkage disequilibrium analysis to genome-wide association studies. The discovery of genetic variants of <i>NOD2</i>, an intracellular pathogen molecular sensor, as risk factors for CD has paved the way for further ...
Hang Thi Thu Nguyen, -, Lapaquette, Pierre, Bringer, Marie-Agnès, Darfeuille-Michaud, Arlette   +3 more
openaire   +4 more sources

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s Disease

Canadian Journal of Gastroenterology, 1997
Atypical perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) occur in most patients with ulcerative colitis but only in a minority of those with Crohn's disease ...
Hugh J Freeman
doaj   +1 more source

Serological markers for prediction of response to anti-tumor necrosis factor treatment in Crohn's disease [PDF]

, 2002
peer reviewedOBJECTIVES: The use of monoclonal anti-tumor necrosis factor (TNF) antibodies (infliximab, Remicade) is a new therapeutic approach for severe refractory luminal or fistulizing, Crohn's disease (CD).
FIASSE, R, POULAIN, D, Rutgeerts, P., Fiasse, René, Rutgeerts, Paul, Esters, N., Reynaert, Hendrik, Reynaert, H., Poulain, Daniel, Poulain, D., Esters, Nele, Van Gossum, A., Belaiche, Jacques, Van Gossum, André, Pelckmans, Paul, PELCKMANS, P, Bossuyt, Xavier, Pescatore, Pierre, PESCATORE, P, Joossens, Sofie, Louis, E., VAN GOSSUM, A, ESTERS, N, RUTGEERTS, P, Noman, Maja, Vermeire, S., Noman, M., De Vos, M., Bela\uefche, J., De Vos, M, JOOSSENS, S, NOMAN, M, LOUIS, E, Belgian Group of Infliximab Expanded Access Program in Crohn's Disease, BOSSUYT, X, Louis, Edouard, Bossuyt, X., Fiasse, R., De Vos, Martine, Pescatore, Paul, Pelckmans, P., VERMEIRE, S, BELAICHE, J, REYNAERT, H, Joossens, S., Pescatore, P., Vermeire, Séverine   +46 more
core   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Prediction of Perianal Fistula in Crohn’s Disease by Computed Tomography Enterography

The Turkish Journal of Gastroenterology
Background/Aims: The purpose of this study was to investigate whether computed tomography enterography can be used to predict the presence of perianal fistula in Crohn’s disease patients.
Genghuan Ni, Hongwei Zhao, Haiyan Shen, Senjuan Li, Weiqun Ao   +4 more
doaj   +1 more source