Results 61 to 70 of about 10,538,494 (333)

Necrobiosis lipoidica of the breast associated with Crohn’s disease: a case report

Journal of Medical Case Reports, 2023
Background Necrobiosis lipoidica located to the breast; without evidence of glucose intolerance, is extremely rare, and its association to Crohn’s disease is not usual.
Awatef Kelati, François Durupt, Brigitte Balme   +2 more
doaj   +1 more source

Late onset crohns ileitis—A diagnostic dilemma

Journal of Family Medicine and Primary Care, 2022
Crohn's disease may affect individuals across all age groups. Usually, it tends to start at a young age, hence late onset Crohn's disease may be difficult to diagnose.
Ashok Sunder, Manish Kumar, Sudip Saha, Bhagyalakshmi Satyanarayan   +3 more
doaj   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

ECCO Guidelines on Therapeutics in Crohn's Disease: medical treatment.

Journal of Crohn's & Colitis, 2019
This article is the second in a series of two publications relating to the European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn’s disease.
J. Torres, S. Bonovas, Glen Doherty, T. Kucharzik, J. Gisbert, T. Raine, M. Adamina, A. Armuzzi, Oliver Bachmann, P. Bager, L. Biancone, B. Bokemeyer, P. Bossuyt, J. Burisch, Paul Collins, A. El‐Hussuna, P. Ellul, Cornelia Frei-Lanter, F. Furfaro, C. Gingert, P. Gionchetti, F. Gomollón, Marien González-Lorenzo, Hannah Gordon, T. Hlavatý, P. Juillerat, Konstantinos Katsanos, U. Kopylov, E. Krustiņš, T. Lytras, C. Maaser, F. Magro, John Kenneth Marshall, P. Myrelid, Gianluca Pellino, I. Rosa, J. Sabino, E. Savarino, A. Spinelli, Laurents P. S. Stassen, Mathieu Uzzan, S. Vavricka, B. Verstockt, J. Warusavitarne, O. Zmora, G. Fiorino   +45 more
semanticscholar   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Esophageal Crohn's Disease Treated “Topically” with Swallowed Aerosolized Budesonide

Case Reports in Medicine, 2010
Proximal Crohn's disease, involving the esophagus, the stomach, the duodenum, and the proximal jejunum, is uncommon. Treatment for proximal Crohn's disease is based on data derived from case series than from controlled trials.
Petros Zezos, Georgios Kouklakis, Anastasia Oikonomou, Michail Pitiakoudis, Constantinos Simopoulos   +4 more
doaj   +1 more source

Autophagy and Crohn's Disease [PDF]

Journal of Innate Immunity, 2013
Advances in genetics have shed light on the molecular basis of Crohn's disease (CD) predisposition and pathogenesis, via linkage disequilibrium analysis to genome-wide association studies. The discovery of genetic variants of <i>NOD2</i>, an intracellular pathogen molecular sensor, as risk factors for CD has paved the way for further ...
Hang Thi Thu Nguyen, -, Lapaquette, Pierre, Bringer, Marie-Agnès, Darfeuille-Michaud, Arlette   +3 more
openaire   +4 more sources

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Development and validation of a pediatric Crohn's disease activity index.

Journal of Pediatric Gastroenterology and Nutrition - JPGN, 1991
Clinical and laboratory observations of 133 children and adolescents with Crohn's disease were used to validate an index of severity of illness previously developed by a group of senior pediatric gastroenterologists at a research forum in April 1990 ...
J. Hyams, G. Ferry, Francine S. Mandel, J. Gryboski, P. Kibort, B. Kirschner, A. Griffiths, A. Katz, R. Grand, J. Boyle, W. Michener, Joseph Levy, M. Lesser   +12 more
semanticscholar   +1 more source

Crohn’s disease as an immunodeficiency [PDF]

Expert Review of Clinical Immunology, 2010
The pathogenesis of Crohn's disease (CD) has widely been regarded as the consequence of a dysregulated T-cell-mediated response to intestinal microbes, and the majority of the worldwide research effort has focused on characterizing and treating the chronic inflammatory phase of the disease.
Arkwright, Peter; id_orcid 0000-0002-7411-5375, Hayee, Bu'Hussain, Rahman, Farooq Z., Sewell, Gavin, Smith, Andrew M., Segal, Anthony W.   +5 more
openaire   +2 more sources