Results 61 to 70 of about 4,909,303 (275)

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Esophageal Crohn's Disease Treated “Topically” with Swallowed Aerosolized Budesonide

Case Reports in Medicine, 2010
Proximal Crohn's disease, involving the esophagus, the stomach, the duodenum, and the proximal jejunum, is uncommon. Treatment for proximal Crohn's disease is based on data derived from case series than from controlled trials.
Petros Zezos, Georgios Kouklakis, Anastasia Oikonomou, Michail Pitiakoudis, Constantinos Simopoulos   +4 more
doaj   +1 more source

Upadacitinib in Patients With Difficult-to-Treat Crohn's Disease [PDF]

Upadacitinib has recently been approved for treating Crohn's disease (CD). Here, we report on the effectiveness and safety of upadacitinib in a cohort of patients with difficult-to-treat CD being cared for at clinical centers across ...
Lorenzo Bertani, Paola Balestrieri, Marzo, Manuela, Soriano, Alessandra, Conforti, Francesco Simone, Cristina Bezzio, Principi, Maria Beatrice, Carolina Cavalli, Savarino, Edoardo V, Angela Variola, Bodini, Giorgia, Alessandro Armuzzi, Casini, Valentina, Armuzzi, Alessandro, Michele Campigotto, Variola, Angela, Silvio Danese, Balestrieri, Paola, Manuela Marzo, Aratari, Annalisa, Barberio, Brigida, Annalisa Aratari, Cavalli, Carolina, Calabrese, Emma, Savarino Edoardo, Cappello, Maria, Andrea Michielan, Danese, Silvio, Maria Cappello, Ceccarelli, Linda, Valentina Casini, Bertani, Lorenzo, Alessandra Soriano, Mauro Mastronardi, Federica Furfaro, Franco Scaldaferri, Giorgia Bodini, Giuseppe Biscaglia, Campigotto, Michele, Emma Calabrese, Linda Ceccarelli, Flavio Andrea Caprioli, Mastronardi, Mauro, Furfaro, Federica, Caprioli, Flavio Andrea, Saibeni, Simone, Franchellucci, Gianluca, Biscaglia, Giuseppe, Michielan, Andrea, Simone Saibeni, Bezzio, Cristina, Francesco Simone Conforti, Scaldaferri, Franco, Maria Beatrice Principi, Gianluca Franchellucci, Barberio Brigida   +55 more
core   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Is It a Crohn’s Disease? [PDF]

Gastroenterology, 2021
Jun-Yan, Qu, Zhen, Li
openaire   +2 more sources

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Circulating tRF-Gly-GCC as a biomarker for colorectal cancer and Crohn’s disease activity

Scientific Reports
Distinguishing intestinal inflammation from colorectal cancer remains challenging using non-invasive biomarkers. tRNA-derived fragments have been implicated in cancer, but their role in Crohn’s disease activity and their ability to differentiate ...
Sarah Salah, Fatma Dwedar, Rasha Nassra, Abeer Mahmoud, Mai Zahra   +4 more
doaj   +1 more source

Ustekinumab-induced Henoch-Schönlein purpura in Crohn’s disease: a case report and literature review [PDF]

Intestinal Research
Crohn’s disease is a chronic inflammatory disease of the digestive tract with extraintestinal manifestations, which include skin conditions, arthritis, ocular inflammation, and several autoimmune conditions. Dermatologic manifestations in Crohn’s disease
Merih Deniz Toruner, Tugce Guvenir, Volkan Yilmaz, Ramazan Erdem Er, Murat Toruner   +4 more
doaj   +1 more source

Crohn’s disease as an immunodeficiency [PDF]

Expert Review of Clinical Immunology, 2010
The pathogenesis of Crohn's disease (CD) has widely been regarded as the consequence of a dysregulated T-cell-mediated response to intestinal microbes, and the majority of the worldwide research effort has focused on characterizing and treating the chronic inflammatory phase of the disease.
Arkwright, Peter; id_orcid 0000-0002-7411-5375, Hayee, Bu'Hussain, Rahman, Farooq Z., Sewell, Gavin, Smith, Andrew M., Segal, Anthony W.   +5 more
openaire   +2 more sources

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source