Results 81 to 90 of about 4,909,303 (275)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Is It Crohn’s Disease? [PDF]

Gastroenterology, 2020
Parigi, Tommaso Lorenzo, Bonifacio, Cristiana, Danese, Silvio   +2 more
openaire   +2 more sources

Prescription of physical exercise in Crohn's disease [PDF]

, 2009
BackgroundPhysical exercise may be potentially beneficial for recovering physical condition and improving quality of life in populations suffering from chronic conditions, but little is known about its effects on patients suffering from Crohn's disease ...
Pérez, Carlos Ayán
core   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Non-invasive fluorescence sensing reveals changes in intestinal barrier function and gastric emptying rate in a first-in-human study of Crohn’s disease

Therapeutic Advances in Gastroenterology
Background: Crohn’s disease is characterised by multifaceted changes in gut function, involving not just inflammatory effects but also alterations in gut barrier function and gastric motility.
Jonathan Gan, Qian Chen, Elena Monfort Sanchez, Nilanjan Mandal, Jiacheng Xu, Zixin Wang, Arjun Agarwal, Emmanuel Oluwatunmise, Pratik Ramkumar, Ash Salam, Elena Chekmeneva, María Gómez-Romero, Lynn Maslen, Sharmili Balarajah, Robert Perry, Karl King Yong, Jonathan Hoare, Nick Powell, James Alexander, James Avery, Hutan Ashrafian, Ara Darzi, Alex J. Thompson   +22 more
doaj   +1 more source

Uveitis as first manifestation of probably Crohn's disease

Revista Brasileira de Oftalmologia, 2012
Extraintestinal manifestations of Crohn's disease are common. Although ocular complications of Crohn's disease are infrequent, most ocular manifestations include iritis, uveitis, episcleritis, scleritis and conjuntivitis.
Ieda Maria Alexandre Barreira, Ricardo Evangelista Marrocos de Aragão, Ariosto Bezerra Vale, Virgínia Apolônio Vieira, Luanna Biana Costa Bezerra   +4 more
doaj   +1 more source

Long-term safety and efficacy of adalimumab in Japanese patients with moderate to severe Crohn's disease [PDF]

, 2014
Background and aimsAdalimumab has been shown to be effective and well tolerated in patients with Crohn's disease. This analysis reports the results of a cohort of Japanese patients with moderate to severe Crohn's disease who were evaluated for up to ...
Thakkar, Roopal, Mostafa, Nael M., Arora, Vipin, Chao, Jingdong, Watanabe, Mamoru, Camez, Anne, Thakkar, Roshni, Hibi, Toshifumi, Petersson, Joel   +8 more
core   +1 more source

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double‐Blind, Proof‐of‐Concept Study

Arthritis &Rheumatology, EarlyView.
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher, Iain B. McInnes, Enrique R. Soriano, Joseph F. Merola, Paul Bird, Vinod Chandran, Edaire Cheng, Elena Reynoso, Warner Chen, Maoji Li, Lianne S. Gensler, Philip J. Mease, Christopher T. Ritchlin   +12 more
wiley   +1 more source

Impact of fatigue in Crohn's disease is negatively related to resting state functional connectivity between the superior parietal lobule and parahippocampal gyrus/hippocampus

Frontiers in Human Neuroscience
IntroductionCrohn's disease is one phenotype of inflammatory bowel disease (IBD). Fatigue is a common and burdensome symptom for persons with Crohn's disease.
Theresa A. McIver, Theresa A. McIver, Theresa A. McIver, Charles N. Bernstein, Charles N. Bernstein, Ruth Ann Marrie, Ruth Ann Marrie, Chase R. Figley, Chase R. Figley, Md Nasir Uddin, Md Nasir Uddin, Md Nasir Uddin, John D. Fisk, Lesley A. Graff, Lesley A. Graff, Ronak Patel, Erin L. Mazerolle, Jennifer Kornelsen, Jennifer Kornelsen, Jennifer Kornelsen   +19 more
doaj   +1 more source