Results 41 to 50 of about 4,909,303 (275)

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Utility of serological markers in inflammatory bowel diseases: Gadget or magic? [PDF]

, 2007
The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Although anti-Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely ...
Papp, Mária, Lakatos, Péter László, Norman, G. L., Altorjay, István   +3 more
core   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Timing of ileocolonic anastomosis in ileocecal resection in Crohn's disease [PDF]

, 2023
openABSTRACT Background - Crohn's disease (CD) is a chronic inflammatory disorder affecting the gastrointestinal tract with no current curative treatment. Despite significant improvements in medical treatments, surgery is still necessary in most cases,
BOSCARO, VITTORIA
core  

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

A Rare Presentation of Crohn's Disease [PDF]

, 2008
Free peritoneal perforation is a rare complication of Crohn's disease with a report of only 100 cases in the literature. It needs an emergency exploration and an unaware general surgeon is confounded in intraoperative decision-making.
Bhat, Sriram M, M, Ashfaque, Ashfaque M, Sriram Bhat M, Sendhil RK, Balu K, K, Balu, Bhat M, Sriram, Madhusudhanan J, J, Madhusudhanan, RK, Sendhil   +10 more
core  

ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment [PDF]

This article is the second in a series of two publications on the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's disease.
Iqbal, Nusrat,, Adamina, Michel,, Iacucci, Marietta,, Verstockt, Bram, El-Hussuna, Alaa, Adamina, Michel, Casanova, María José, Sica, G, Yanai, Henit,, Atreya, Raja, Gisbert, Javier, Buskens, Christianne, Buskens, Christianne Johanna,, Czuber-Dochan, Wladyslawa,, Sabino, João Guedelha, Raine, Tim,, Iacucci, Marietta, Brown, Steven Ross, Kopylov, Uri, Moran, Gordon William,, Minozzi, Silvia,, Iqbal, Nusrat, Burisch, Johan, Kopylov, Uri,, Warusavitarne, Janindra,, El-Hussuna, Alaa,, Agrawal, Manasi, Atreya, Raja,, Sigall-Boneh, Rotem, Sigall-Boneh, Rotem,, Reenaers, Catherine, Kobayashi, Taku, Sica, Giuseppe S.,, Kobayashi, Taku,, Moran, Gordon, Burisch, Johan,, Raine, Tim, de Groof, Joline,, Fiorino, Gionata, Allocca, Mariangela,, Gordon, Hannah, Sabino, Joao Guedelha,, Maaser, Christian,, Luglio, Gaetano, Gisbert, Javier P.,, Buskens, Christianne Johanna, Myrelid, Pär,, Agrawal, Manasi,, Kapizioni, Christina, Kotze, Paulo Gustavo, Peros, Georgios, Gisbert, Javier P, Verstockt, Bram,, Hanzel, Jurij,, Luglio, Gaetano,, Maaser, Christian, Karmiris, Konstantinos,, Casanova, Maria Jose,, de Groof, Joline, Czuber-Dochan, Wladyslawa, Battat, Robert,, Fidalgo, Catarina,, Myrelid, Pär, Bettenworth, Dominik, Chaparro, Maria,, Karmiris, Konstantinos, Vavricka, Stephan R.,, Ellu, Pierre,, Bislenghi, Gabriele,, Papamichael, Konstantinos, Moran, Gordon William, Ellu, Pierre, Ellul, Pierre, Hanzel, Jurij, Yanai, Henit, Kotze, Paulo Gustavo,, Reenaers, Catherine,, Vavricka, Stephan R, Peros, Georgios,, Warusavitarne, Janindra, Noor, Nurulamin,, Papamichael, Konstantinos,, Holubar, Stefan, Vavricka, Stephan R., Fiorino, Gionata,, Allocca, Mariangela, Bislenghi, Gabriele, Kapizioni, Christina,, Battat, Robert, Gordon, Hannah,, Papamichail, Konstantinos, Brown, Steven Ross,, Noor, Nurulamin, Bettenworth, Dominik,, Minozzi, Silvia, Sica, Giuseppe, Chaparro, Maria, Fidalgo, Catarina, Holubar, Stefan,   +98 more
core   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Telocytes in Crohn's disease [PDF]

Journal of Cellular and Molecular Medicine, 2013
AbstractCrohn's disease (CD) is a relapsing chronic inflammatory disorder that may involve all the gastrointestinal tract with a prevalence of terminal ileum. Intestinal lesions have a characteristic discontinuous and segmental distribution and may affect all layers of the gut wall.
A. F. Milia, RUFFO, MARTINA, MANETTI, MIRKO, ROSA, IRENE, D. Conte, FAZI, MARILENA, MESSERINI, LUCA, IBBA, LIDIA   +7 more
openaire   +3 more sources