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Aretaeus of Cappadocia (1st century CE) described a young man with chronic and recurring abdominal distress possibly representing the first recorded instance of Crohn disease (CD).1-3 More evidence that this disease was extant for many years comes from the description of the 10th century English king, Alfred “the great,” who suffered for many years ...
Stephen A. Geller +1 more
openaire +3 more sources
Systems biology in inflammatory bowel diseases [PDF]
Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US.
Iliopoulos, D, Koukos, G, Polytarchou, C
core +1 more source
Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients [PDF]
The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease.
Folwaczny, Christian +3 more
core +1 more source
Progress and Clinical Applications of Crohn’s Disease Exclusion Diet in Crohn’s Disease
Crohn’s disease is a chronic intestinal inflammatory disorder of unknown etiology. Although the pharmacotherapies for Crohn’s disease are constantly updating, nutritional support and adjuvant therapies have recently gained more attention.
Duo Xu +5 more
doaj +1 more source
Reactive angioendotheliomatosis (RAE) is a rare cutaneous vascular disorder, usually associated with systemic diseases. RAE has previously been described only in the skin, with the single exception of one case involving the intestine in a patient with ...
Hwajeong Lee, MD +1 more
doaj +1 more source
Metastatic Crohn’s disease despite infliximab therapy [PDF]
Metastatic Crohn’s disease is a rare extraintestinal manifestation of Crohn’s disease. It is characterized by polymorphic skin lesions formed by non-caseating granulomas located on anatomical sites distant from the gastrointestinal tract.
Sara Campos +3 more
doaj +1 more source
The adherent/invasive escherichia coli (AIEC) strain LF82 invades and persists in human prostate cell lineRWPE-1 activating a strong inflammatory response [PDF]
Adherent/invasive Escherichia coli (AIEC) strains have recently been receiving increased attention because they are more prevalent and persistent in the intestine of Crohn's disease (CD) patients than in healthy subjects.
ALEANDRI, MARTA +13 more
core +2 more sources
Adenocarcinoma arising from chronic perianal crohn's disease: a case report
Malignant transformation of perineal fistula in Crohn's disease has rarely been reported. We report a case of Crohn's disease with recurrent perineal fistulas.
Hanane Massit +5 more
doaj +1 more source
Role of MR enterography in acute and chronic stages of Crohn's disease
Background: Crohn's disease (CD) is an autoimmune disease affecting young, adult with relapsing course. MRI is now considered a safe alternative for, diagnosing complication of Crohn s disease.
Rabab Yasin +2 more
doaj +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source

