Mucosal healing and a fall in mucosal pro‐inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn’s disease [PDF]
, 2000 Fell +8 more
openalex +1 more source
The Journal of Clinical Pharmacology, EarlyView.Abstract Compared to traditional small molecule drugs, monoclonal antibodies (mAbs) often display more complex pharmacokinetic (PK) and pharmacodynamic (PD) properties that may be impacted by disease‐specific factors. For mAbs in non‐oncology indications, where the same drug might be used for conditions involving different organ systems and/or having ...
Sherouk M. Tawfik, Fei Tang
wiley +1 more source
Budesonide in the treatment of Crohn’s disease: a meta‐analysis [PDF]
, 2000 Claudio Papi +5 more
openalex +1 more source
The Journal of Clinical Pharmacology, EarlyView.Abstract This study aimed to characterize the pharmacokinetics (PK) of etrolizumab, an IgG1‐humanized monoclonal anti‐β7 integrin antibody, and assess its exposure–response (ER) relationship for key clinical outcomes in patients with moderately‐to‐severely active Crohn's disease.
Anita Moein +4 more
wiley +1 more source
Crohn’s disease in Wales, 1967–1976; an epidemiological survey based on hospital admissions
, 1980 J F Mayberry, J. Rhodes, R G Newcombe
openalex +1 more source
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives We determined the prevalence of anemia and its characteristics in children with newly diagnosed inflammatory bowel disease (IBD) and investigated its trend during follow‐up. Methods An observational, multicenter cohort study of IBD children with anemia at the diagnosis enrolled in the Italian Society of Pediatric Gastroenterology ...
Giulia D'Arcangelo +19 more
wiley +1 more source
Testing the relationship between gut permeability, elevation of systemic lipopolysaccharides and chronic disease : A thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Massey University, Manawatu, New Zealand [PDF]
, 2016 The aim of my thesis was to test whether an increase in the permeability of the gut is accompanied by an increase in the level of systemic lipopolysaccharides (LPS), also referred to as endotoxin.
Gnauck, Anne
core
Cellular localization of complement C3 and C4 transcripts in intestinal specimens from patients with Crohn’s disease [PDF]
, 2000 J Laufer +6 more
openalex +1 more source
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives Living with inflammatory bowel disease (IBD) can have a significant impact on children. Many children with IBD experience symptoms of anxiety or depression. Routine screening for mental health has been recommended. This preregistered study aimed to describe the implementation of patient‐reported outcome measures (PROMs) in routine ...
Marije van Dalen +6 more
wiley +1 more source
Successful treatment of therapy-resistant metastatic Crohn's desiase with infliximab [PDF]
, 2004 CASTIGLIONE, FABIANA +5 more
core +1 more source