Results 61 to 70 of about 102,860 (309)

Late onset crohns ileitis—A diagnostic dilemma

Journal of Family Medicine and Primary Care, 2022
Crohn's disease may affect individuals across all age groups. Usually, it tends to start at a young age, hence late onset Crohn's disease may be difficult to diagnose.
Ashok Sunder, Manish Kumar, Sudip Saha, Bhagyalakshmi Satyanarayan   +3 more
doaj   +1 more source

Additional file 5: of Genome analysis of E. coli isolated from Crohnâ s disease patients

, 2017
Phage sensitivity test of E. coli CD-isolates (see Methods). (DOC 45 kb)
Rakitina, Daria, Manolov, Alexander, Kanygina, Alexandra, Garushyants, Sofya, Baikova, Julia, Alexeev, Dmitry, Ladygina, Valentina, Kostryukova, Elena, Larin, Andrei, Semashko, Tatiana, Karpova, Irina, Babenko, Vladislav, Ismagilova, Ruzilya, Malanin, Sergei, Gelfand, Mikhail, Ilina, Elena, Gorodnichev, Roman, Lisitsyna, Eugenia, Aleshkin, Gennady, Scherbakov, Petr, Khalif, Igor, Shapina, Marina, Maev, Igor, Andreev, Dmitry, Govorun, Vadim   +24 more
openaire   +1 more source

Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. [PDF]

, 2010
Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of
Seiderer, J., Seiderer Julia, Folwaczny, M., Ochsenkühn, Thomas, Fries, C., Beigel, F., Klein, Wolfram, Glas, J., Müller-Myhsok, B., Folwaczny Matthias, Darina Roeske, Matthias Folwaczny, Bertram Müller-Myhsok, Göke, Burkard, Jörg T Epplen, Epplen Jörg T., Diegelmann Julia, Fries Christoph, Melinda Nagy, Pfennig Simone, Brand, Stephan, Nagy, M., Göke, B., Brand Stephan, Nagy, Melinda, Thomas Ochsenkühn, Weidinger Maria, Beigel, Florian, Weidinger, Maria, Ochsenkühn, T., Klein, Wolfgang, Epplen, Jörg T., Julia Diegelmann, Beigel Florian, Müller-Myhsok Bertram, Göke, Burkhard, Fries, Christoph, Folwaczny, Matthias, Pfennig, S., Pfennig, Simone, Peter Lohse, Seiderer, Julia, Roeske, Darina, Glas, Jürgen, Epplen, J., Diegelmann, J., Lohse, P., Christoph Fries, Ochsenkühn Thomas, Müller-Myhsok, Bertram, Weidinger, M., Burkhard Göke, Göke Burkhard, Klein, W., Stephan Brand, Maria Weidinger, Roeske Darina, Brand, S., Jürgen Glas, Klein Wolfram, Roeske, D., Lohse, Peter, Diegelmann, Julia, Nagy Melinda, Simone Pfennig, Wolfram Klein, Glas Jürgen, Florian Beigel, Lohse Peter, Julia Seiderer   +69 more
core   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Additional file 12: of Genome analysis of E. coli isolated from Crohnâ s disease patients

, 2017
Competition co-culture of CD-E. coli and isolates from healthy individuals. (DOC 56 kb)
Rakitina, Daria, Manolov, Alexander, Kanygina, Alexandra, Garushyants, Sofya, Baikova, Julia, Alexeev, Dmitry, Ladygina, Valentina, Kostryukova, Elena, Larin, Andrei, Semashko, Tatiana, Karpova, Irina, Babenko, Vladislav, Ismagilova, Ruzilya, Malanin, Sergei, Gelfand, Mikhail, Ilina, Elena, Gorodnichev, Roman, Lisitsyna, Eugenia, Aleshkin, Gennady, Scherbakov, Petr, Khalif, Igor, Shapina, Marina, Maev, Igor, Andreev, Dmitry, Govorun, Vadim   +24 more
openaire   +1 more source

PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]

, 2012
Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Darina Czamara, Richard H. Duerr (107855), M. Ilyas Kamboh (107850), Jean-Paul Achkar (107846), Andre Franke (77511), Giulia Pasciuto, Julia Seiderer (107820), Tobias Balschun, Giulia Pasciuto (107827), Seiderer, Julia, Pasciuto, Giulia, Glas, Jürgen, Duerr, Richard H., Bertram Müller-Myhsok, Tobias Balschun (77515), Richard H Duerr, Jürgen Glas (107816), Jean-Paul Achkar, Müller-Myhsok, Bertram, Christiane Wolf (107839), Bertram Müller-Myhsok (33498), Martin Wetzke, Torsten Olszak (107835), Brand, Stephan, Stephan Brand, Andre Franke, Franke, Andre, Czamara, Darina, Martin Wetzke (107833), Achkar, Jean-Paul, Julia Diegelmann (107830), Jürgen Glas, Christiane Wolf, Wetzke, Martin, Diegelmann, Julia, Wolf, Christiane, Balschun, Tobias, Darina Czamara (107824), Stephan Brand (107861), Julia Diegelmann, Torsten Olszak, Julia Seiderer, M Ilyas Kamboh, Kamboh, M. Ilyas, Olszak, Torsten   +44 more
core   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Additional file 7: of Genome analysis of E. coli isolated from Crohnâ s disease patients

, 2017
plLF82 homologs in CD-associated E. coli. (A) Sequence similarity of CD isolates with the plasmid pLF82 (100 kb), (B) and (C) functions of proteins common between pLF82 or pJJ1886_4 and CD isolates The functions were obtained from original annotation, complemented by Prokka annotation and BLAST protein similarity search.
Rakitina, Daria, Manolov, Alexander, Kanygina, Alexandra, Garushyants, Sofya, Baikova, Julia, Alexeev, Dmitry, Ladygina, Valentina, Kostryukova, Elena, Larin, Andrei, Semashko, Tatiana, Karpova, Irina, Babenko, Vladislav, Ruzilya Ismagilova, Malanin, Sergei, Gelfand, Mikhail, Ilina, Elena, Gorodnichev, Roman, Lisitsyna, Eugenia, Aleshkin, Gennady, Scherbakov, Petr, Khalif, Igor, Shapina, Marina, Maev, Igor, Andreev, Dmitry, Govorun, Vadim   +24 more
openaire   +1 more source

Safety aspects of infliximab in inflammatory bowel disease patients - A retrospective cohort study in 100 patients of a German University Hospital [PDF]

, 2004
Background: Infliximab, a chimeric anti-tumour necrosis factor monoclonal antibody with potent anti-inflammatory effects, represents an effective treatment option in patients with severe inflammatory bowel disease (IBD).
Seiderer, J., Burkhard Göke, Göke, B., Ochsenkühn, Thomas, Thomas Ochsenkühn, Julia Seiderer   +5 more
core   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source