Results 81 to 90 of about 162,990 (305)

Environmental Factors in the Relapse and Recurrence of Inflammatory Bowel Disease:A Review of the Literature [PDF]

, 2015
The causes of relapse in patients with Crohn's disease (CD) and ulcerative colitis (UC) are largely unknown. This paper reviews the epidemiological and clinical data on how medications (non-steroidal anti-inflammatory drugs, estrogens and antibiotics ...
A Bitton, A Bitton, A Dignass, A Kaser, A Lunderquist, A Timmer, AJ Wakefield, AM Meyer, AN Ananthakrishnan, Andrew R. Hart, AP Dhillon, B Boye, BD Levy, C Abraham, C Luong, C Mowat, CN Bernstein, CS Guerreiro, CS North, D Lader, DA Gorard, DC Baumgart, DC Baumgart, E Lindberg, E Stepien, EA Magee, EA Magee, EA Miles, EF Foley, EM Sternberg, F Backhed, F Casellas, FN Aberra, G Bonizzi, G Bouma, G Cipolla, G Savoye, GE Reese, GF Bonner, GP Chrousos, H Brunner, H Tornqvist, IC Solberg, J Cosnes, J Cosnes, J Cosnes, J Eaden, JA Dominitz, JA Mancini, JB Felder, JC Meijers, JM Evans, KJ Khan, KS Rothfuss, L Beaugerie, L Beaugerie, L LeResche, L Lu, LM Lichtenberger, LR Sutherland, LR Sutherland, M Aslam, M Cottone, M Dybdahl, MB Grisham, MC Aldhous, MC Pitcher, MN Merrett, MT Severinsen, NJ Simmonds, NP Thompson, O Hovde, OA Hatoum, P Seksik, PJ Loll, R Reid, R Schreck, RD Cohen, RK Linskens, RM Beattie, RS Barua, S Danese, S Hayashi, S Levenstein, S Parcell, S Sigaud, S Singh, S Zhang, Simon S. M. Chan, SL Jowett, SM Collins, SM Collins, SS Hecht, ST Smale, SU Christl, SV Kane, T Hisamatsu, THJ Florin, Thomas D. Martin, U Erikson   +99 more
core   +1 more source

Additional file 2: of Dietary treatment of Crohnâ s disease: perceptions of families with children treated by exclusive enteral nutrition, a questionnaire survey

, 2017
Survey on Dietary Treatment for Crohnâ s Disease Child/Young Person Version. (PDF 243 kb)
Svolos, Vaios, Gerasimidis, Konstantinos, Buchanan, Elaine, Curtis, Lee, Garrick, Vikki, Hay, Jacqueline, Laird, Susan, Munro, Joanna, Gaya, Daniel, Russell, Richard, Hansen, Richard   +10 more
openaire   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Ambulatory surgery for perianal Crohn’s disease. Study of feasibility [PDF]

, 2018
Background. One-third of Crohn’s disease (CD) patients present perianal fistula. The gold standard in the diagnosis and treatment of symptomatic perianal disease (PAD) in CD is the exploration of the anal canal and distal rectum under anesthesia (EUA ...
Arcudi, C., Biancone, L., Campanelli, M., Del Vecchio Blanco, G., Di Carlo, S., Di Giorgio, A., Divizia, A., Fiorani, C., Scaramuzzo, R., Sibio, S., Sica, and G.   +10 more
core   +2 more sources

Additional file 1: Table S1. of Systematic review with meta-analysis: the efficacy and safety of stem cell therapy for Crohnâ s disease

, 2017
Characteristics of excluded studies. (DOCX 35Â kb)
Qiu, Yun, Man-Ying Li, Feng, Ting, Feng, Rui, Mao, Ren, Bai-Li Chen, He, Yao, Zeng, Zhi-Rong, Zhang, Sheng-Hong, Min-Hu Chen   +9 more
openaire   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year follow-up study [PDF]

, 2003
AIM: IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study.
Balogh, Zsuzsanna, Dávid, Gyula, Kuronya, Pál, Lakatos, László, Lakatos, Péter László, Pandur, Tünde, Tollas, Árpád   +6 more
core   +1 more source

Additional file 3: Table S2. of Systematic review with meta-analysis: the efficacy and safety of stem cell therapy for Crohnâ s disease

, 2017
Assessment of quality of observational studies using Newcastle Ottawa Quality Assessment Scale (NOS) (DOCX 14 kb)
Qiu, Yun, Man-Ying Li, Feng, Ting, Feng, Rui, Mao, Ren, Bai-Li Chen, He, Yao, Zeng, Zhi-Rong, Zhang, Sheng-Hong, Min-Hu Chen   +9 more
openaire   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Cutaneous Crohn’s disease of the vulva after a total colectomy and without gastrointestinal manifestations: A case report

SAGE Open Medical Case Reports, 2019
Crohn’s disease has many cutaneous manifestations. We report a case of a 54-year-old woman, who had non-contiguous vulvar Crohn’s disease despite a total colectomy and the absence of gastrointestinal Crohn’s disease on ileoscopy.
Michal Bohdanowicz, Danny Ghazarian, Cheryl F. Rosen   +2 more
doaj   +1 more source