Results 101 to 110 of about 61,456 (351)
Vulvar Crohn´s disease as extra intestinal manifestation
The Pan African Medical Journal, 2020 Crohn´s disease is a chronic granulomatous inflammatory disorder that usually affects the gastrointestinal tract. It may be associated with extra-intestinal lesions such as genital female manifestations.
Fatima El Mangoub, Jaouad Kouach
doaj +1 more source
Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease
Advanced NanoBiomed Research, EarlyView.Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang +5 more
wiley +1 more source
Mycobacterium avium subspecies paratuberculosis bacteremia in type 1 diabetes mellitus: an infectious trigger? [PDF]
, 2008 Mycobacterium avium subspecies paratuberculosis (MAP) is the established cause of paratuberculosis in ruminants (i.e., Johne disease). The bacterium is shed in the milk of infected cows and survives pasteurization.
Paccagnini, Daniela +2 more
core
An evidence-based review of natalizumab therapy in the management of Crohn’s disease
Therapeutics and Clinical Risk Management, 2009 Raja GR Edula, Michael F PiccoMayo Clinic, Jacksonville, Florida, USAAbstract: Treatment options for Crohn’s disease have evolved beyond the early goals of induction and remission and are now more focused on preventing complications by altering
Raja GR Edula, Michael F Picco
doaj
Clinical and Translational Gastroenterology, 2017 Fistulas still represent one of the most important complications in patients with Crohn's disease (CD). At least one third of CD patients suffer from fistulas during their disease course and amongst them longstanding remission of complex fistulas occurs only in about one third. So far, fistula pathogenesis is only partially understood.
Scharl, Michael +2 more
openaire +3 more sources
Transperineal Ultrasonography in Perianal Crohn Disease: A Valuable Imaging Modality
Canadian Journal of Gastroenterology and Hepatology, 2015 Aims of treatment for Crohn disease have moved beyond the resolution of clinical symptoms to objective end points including endoscopic and radiological normality. Regular re-evaluation of disease status to safely, readily and reliably detect the presence
Emily K Wright +5 more
doaj +1 more source
Immunotherapy of Crohn′s disease
Mediators of Inflammation, 1998 Although the initiating events of Crohn′s disease are unknown, models of experimental colitis have provided new insights in the immunologically mediated pathways of mucosal inflammation. In Crohn′s disease activated mucosal T lymphocytes produce proinflammatory cytokines within the mucosal compartment. With this understanding, there has been a shift in
van Montfrans, C. +2 more
openaire +6 more sources
Arthritis &Rheumatology, EarlyView.Objective Despite the availability of biologic and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs) to treat rheumatoid arthritis (RA), many patients do not experience optimized disease control. Glucocorticoids are effective but have safety risks.
Frank Buttgereit +13 more
wiley +1 more source
Fournier Gangrene Associated With Crohn Disease [PDF]
, 2000 Tim Jiang +5 more
openalex +1 more source
Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8+ T Cell Clones
Arthritis &Rheumatology, EarlyView.Objective Psoriatic arthritis (PsA) is an HLA class I–associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T cell phenotype and clonality.
Lucy E. Durham +14 more
wiley +1 more source