Results 101 to 110 of about 59,318 (349)
Vulvar Crohn´s disease as extra intestinal manifestation
The Pan African Medical Journal, 2020 Crohn´s disease is a chronic granulomatous inflammatory disorder that usually affects the gastrointestinal tract. It may be associated with extra-intestinal lesions such as genital female manifestations.
Fatima El Mangoub, Jaouad Kouach
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy +4 more
wiley +1 more source
An evidence-based review of natalizumab therapy in the management of Crohn’s disease
Therapeutics and Clinical Risk Management, 2009 Raja GR Edula, Michael F PiccoMayo Clinic, Jacksonville, Florida, USAAbstract: Treatment options for Crohn’s disease have evolved beyond the early goals of induction and remission and are now more focused on preventing complications by altering
Raja GR Edula, Michael F Picco
doaj
Transperineal Ultrasonography in Perianal Crohn Disease: A Valuable Imaging Modality
Canadian Journal of Gastroenterology and Hepatology, 2015 Aims of treatment for Crohn disease have moved beyond the resolution of clinical symptoms to objective end points including endoscopic and radiological normality. Regular re-evaluation of disease status to safely, readily and reliably detect the presence
Emily K Wright +5 more
doaj +1 more source
NOD2 and inflammation: current insights [PDF]
, 2018 The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory ...
Cucchiara, Salvatore +3 more
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Aims Polypharmacy is common in adult patients with inflammatory bowel disease (IBD). This study aims to quantify medication prescriptions and estimate the risk of polypharmacy over time in older adults with IBD. Methods In a nationwide cohort of adult incident IBD patients from 1 April 1996, to 31 December 2019, we examined medication prescriptions ...
Ken Lund +7 more
wiley +1 more source
Simultaneous central retinal artery occlusion and optic nerve vasculitis in Crohn disease
American Journal of Ophthalmology Case Reports, 2017 Purpose: To describe a case of Crohn disease presenting as occlusive vasculitis resulting in a central retinal artery occlusion (CRAO) in one eye and transient ischemic optic neuropathy in the fellow eye.
Razek Georges Coussa +4 more
doaj +1 more source
Intestinal Barrier Glycosylation for Gut Physiology and Pathology
Barrier Immunity, EarlyView.ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley +1 more source
Gut‐microbiota‐brain Axis and post‐traumatic epilepsy
Epilepsia Open, EarlyView.Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley +1 more source
Cell Reports, 2016 The relationship between the host and its microbiota is challenging to understand because both microbial communities and their environments are highly variable.
Feng Wang +22 more
doaj +1 more source