Results 91 to 100 of about 4,849,663 (241)

Distinguishing tuberculosis and Crohn′s disease in developing countries: How certain can you be of the diagnosis?

The Saudi Journal of Gastroenterology, 2009
Distinguishing tuberculosis and Crohn′s disease in patients presenting with chronic abdominal pain and diarrhea is a huge diagnostic challenge, particularly in tuberculosis endemic countries.
Navaneethan Udayakumar, Cherian Jijo, Prabhu Rajesh, Venkataraman Jayanthi   +3 more
doaj  

Deucravacitinib in Active Psoriatic Arthritis: Efficacy and Safety up to 52 Weeks From the Randomized, Double‐Blind, Phase 3 POETYK PsA‐2 Trial

Arthritis &Rheumatology, Accepted Article.
Objective To assess the efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with psoriatic arthritis (PsA) who were naive to biologic disease‐modifying antirheumatic drugs or received tumor necrosis factor inhibitors. Methods In the 52‐week (W), double‐blind, placebo‐controlled, phase 3 POETYK PsA‐2 study
Philip J. Mease, Vinod Chandran, April W. Armstrong, Ricardo Blanco, Alexis Ogdie, Evan L. Siegel, Alice B. Gottlieb, Xiaofeng Zeng, Diamant Thaçi, Mitsumasa Kishimoto, Hendrik Schulze‐Koops, Alan Kivitz, Eva Dokoupilová, Akimichi Morita, Eric M. Ruderman, Michael Plewinski, Kejia Wang, Caroline Sardinas, Eleni Vritzali, John Vaile, Atul Deodhar   +20 more
wiley   +1 more source

Diagnosis of regional enrteritis (Crohn disease)

The Saudi Journal of Gastroenterology, 2003
Regional enteritis (Crohn disease) may present a diagnostic problem that needs to be solved by clinicians practicing in areas known to be endemic for tuberculosis.
Khalil Mohamed
doaj  

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan, Christopher Banfield, Kenneth Hung, Anna Sapone, Vivek Pradhan, Yuxi Zhao, Dana Parsons‐Rich, Grace Lee, Bryce G. Johnson, Elena Peeva, Michael S. Vincent, Valerie M. Clerin   +11 more
wiley   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source

Clinical features of nonspecific ulcerative colitis and Crohn's disease in children [PDF]

Саратовский научно-медицинский журнал, 2010
The article presents the data of age, manifestation, localization and clinical features of course of Crohn's disease and nonspecific ulcerative colitis.
Malakhinova N.A.
doaj  

Metastatic Crohn′s disease of external genitalia

Indian Journal of Dermatology, 2008
Metastatic Crohn′s disease is an uncommon extraintestinal manifestation of Crohn′s disease. Its hallmark features include the presence of cutaneous noncaseating granulomas that are noncontiguous with the gastrointestinal tract or fistula ...
Panackel Charles, John Joseph, Krishnadas Devadas, Vinayakumar Kattoor   +3 more
doaj  

Simultaneous central retinal artery occlusion and optic nerve vasculitis in Crohn disease

American Journal of Ophthalmology Case Reports, 2017
Purpose: To describe a case of Crohn disease presenting as occlusive vasculitis resulting in a central retinal artery occlusion (CRAO) in one eye and transient ischemic optic neuropathy in the fellow eye.
Razek Georges Coussa, Andre Ali-Ridha, Natalia Vila, Rayan Alshareef, John Chen   +4 more
doaj   +1 more source

Quality of life in children with crohn disease

, 2010
Objectives: Quality of life (QOL) is reportedly poor in children with Crohn disease (CD) but improves with increasing disease duration. This article aims to detail QOL in a cohort of Australian children with CD in relation to disease duration, disease ...
Grange, I., Cleghorn, Geoffrey J., Connor, F. L., Cleghorn, G. J., Ee, L., Withers, G. D., Davies, P. S. W., Hill, R. J., Lewindon, P. J., Muir, R., Ee, L. C.   +10 more
core   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source