Results 91 to 100 of about 15,981,489 (330)

Fecal Virome Transplantation in Human Disease and Livestock Production: Evidence, Mechanisms, and Translational Challenges

Animal Research and One Health, EarlyView.
Fecal virome transplantation may reshape bacterial communities and host responses while reducing viable bacterial transfer. Preclinical evidence suggests biological activity, but human efficacy remains uncertain, and translation requires product standardization, causal validation, donor–recipient matching, and rigorous biosafety assessment.
Luanyang Shi, Yongjuan Guan, Guanxiang Liang   +2 more
wiley   +1 more source

Blood-derived DNA Methylation Signatures of Crohn’s Disease and Severity of Intestinal Inflammation

Gastroenterology, 2019
Background & Aims: Crohn’s disease is a relapsing and remitting inflammatory disorder with a variable clinical course. Although most patients present with an inflammatory phenotype (B1), approximately 20% of patients rapidly progresses to complicated ...
Hari Somineni, S. Venkateswaran, V. Kilaru, U. Marigorta, A. Mo, D. Okou, R. Kellermayer, K. Mondal, Dawayland O. Cobb, T. Walters, A. Griffiths, J. Noe, W. Crandall, J. Rosh, D. Mack, M. Heyman, S. Baker, M. Stephens, R. Baldassano, J. Markowitz, M. Dubinsky, Judy H. Cho, J. Hyams, L. Denson, G. Gibson, D. Cutler, K. Conneely, Alicia K. Smith, S. Kugathasan   +28 more
semanticscholar   +1 more source

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

The PRECiSE 2 trial of certolizumab pegol, a new PEGylated anti-TNF agent, in the treatment of Crohn's disease - An interview with David A Schwartz, 13 June 2007

Biologics: Targets & Therapy, 2008
David A SchwartzVanderbilt University Medical Center, Nashville, TN, USAContext: Certolizumab pegol (CDP 870) is a new anti-tumor necrosis factor (TNF) therapy currently in development for the treatment of Crohn’s disease, rheumatoid arthritis,
David A Schwartz
doaj  

Sustained Inhibition of Structural Damage Progression and Improvements in Disease Activity With Guselkumab in Biologic‐Naïve Participants with Active and Erosive Psoriatic Arthritis: Results Through Week 48 of the Phase 3b Randomized, Double‐Blind, Placebo‐Controlled APEX Study

Arthritis &Rheumatology, Accepted Article.
Objective In APEX, guselkumab, which binds to the IL‐23p19 subunit and CD64 on IL‐23‐producing cells, demonstrated significant joint efficacy and inhibition of structural damage progression in participants with active and erosive PsA through Week (W)24; W48 findings are reported herein. Methods The APEX modified full analysis set included 1020 biologic‐
Christopher T. Ritchlin, Philip J. Mease, Laura C. Coates, Alexa P. Kollmeier, Bei Zhou, Yusang Jiang, Karen Bensley, Koeun Im, Rattandeep Batra, Karissa Lozenski, Soumya D. Chakravarty, Proton Rahman, Désirée van der Heijde   +12 more
wiley   +1 more source

Distinguishing tuberculosis and Crohn′s disease in developing countries: How certain can you be of the diagnosis?

The Saudi Journal of Gastroenterology, 2009
Distinguishing tuberculosis and Crohn′s disease in patients presenting with chronic abdominal pain and diarrhea is a huge diagnostic challenge, particularly in tuberculosis endemic countries.
Navaneethan Udayakumar, Cherian Jijo, Prabhu Rajesh, Venkataraman Jayanthi   +3 more
doaj  

A specific gene-microbe interaction drives the development of Crohn’s disease–like colitis in mice

Science immunology, 2019
Combined deficiency of NOD2 and NAPDH oxidase triggers Crohn’s-like disease driven by a mouse pathobiont, Mucispirillum. A mouse model for Crohn’s disease Although several mouse models of inflammatory bowel disease exist, Crohn’s disease has been ...
Roberta Caruso, T. Mathes, E. Martens, Nobuhiko Kamada, Asma Nusrat, N. Inohara, G. Nuñez   +6 more
semanticscholar   +1 more source

Crohn's Disease: The Subsequent Visit

, 2020
: The diagnosis and subsequent management of Crohn's disease are challenging for both the patient and the ...
MD, MSc Francis A Farraye, Dr Jack A Di Palma, MD Catherine S Manolakis, MD Jack A Di Palma   +3 more
core  

Bilateral adrenal infarction in Crohn′s disease

, 2013
Adrenal infarction is an uncommon cause of adrenal insufficiency. We herein present unique occurrence of bilateral adrenal infarction detected on imaging in a young female with known history of Crohn′s disease.
Kanika Khandelwal, Vivek Virmani, John Ryan, Ashish Khandelwal, J Satheesh Krishna   +4 more
core   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source