Results 91 to 100 of about 10,462,861 (343)

Prediction of complicated disease course for children newly diagnosed with Crohn’s disease: a multicentre inception cohort study

The Lancet, 2017
Summary Background Stricturing and penetrating complications account for substantial morbidity and health-care costs in paediatric and adult onset Crohn’s disease.
S. Kugathasan, L. Denson, T. Walters, Mi‐Ok Kim, U. Marigorta, M. Schirmer, K. Mondal, Chunyan Liu, A. Griffiths, J. Noe, W. Crandall, S. Snapper, S. Rabizadeh, J. Rosh, J. Shapiro, S. Guthery, D. Mack, R. Kellermayer, M. Kappelman, S. Steiner, Dedrick E. Moulton, D. Keljo, Stanley Cohen, M. Oliva-Hemker, M. Heyman, A. Otley, S. Baker, Jonathan Evans, B. Kirschner, Ashish S. Patel, D. Ziring, B. Trapnell, F. Sylvester, Michael C. Stephens, R. Baldassano, J. Markowitz, Judy H. Cho, R. Xavier, C. Huttenhower, B. Aronow, G. Gibson, J. Hyams, M. Dubinsky   +42 more
semanticscholar   +1 more source

Spondyloarthritis Preceding and Following Inflammatory Bowel Disease Diagnosis and Risk Factors: A Temporal Trends Analysis in a Population‐Based Cohort

Arthritis &Rheumatology, EarlyView.
Objective Spondyloarthritides (SpA) and inflammatory bowel disease (IBD) are immune‐mediated diseases with overlap in clinical and immunologic features. However, temporal correlation of SpA and IBD in individual patients and risk factors are not well characterized.
Manasi Agrawal, Christian N. Sørensen, Gry J. Poulsen, Bahar Moghaddam, Percio S. Gulko, Jean‐Frederic Colombel, Tine Jess   +6 more
wiley   +1 more source

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double‐Blind, Proof‐of‐Concept Study

Arthritis &Rheumatology, EarlyView.
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher, Iain B. McInnes, Enrique R. Soriano, Joseph F. Merola, Paul Bird, Vinod Chandran, Edaire Cheng, Elena Reynoso, Warner Chen, Maoji Li, Lianne S. Gensler, Philip J. Mease, Christopher T. Ritchlin   +12 more
wiley   +1 more source

Blood-derived DNA Methylation Signatures of Crohn’s Disease and Severity of Intestinal Inflammation

Gastroenterology, 2019
Background & Aims: Crohn’s disease is a relapsing and remitting inflammatory disorder with a variable clinical course. Although most patients present with an inflammatory phenotype (B1), approximately 20% of patients rapidly progresses to complicated ...
Hari Somineni, S. Venkateswaran, V. Kilaru, U. Marigorta, A. Mo, David T. Okou, R. Kellermayer, K. Mondal, Dawayland O. Cobb, T. Walters, A. Griffiths, J. Noe, W. Crandall, J. Rosh, D. Mack, M. Heyman, S. Baker, Michael C. Stephens, R. Baldassano, J. Markowitz, M. Dubinsky, Judy H. Cho, J. Hyams, L. Denson, G. Gibson, D. Cutler, K. Conneely, Alicia K. Smith, S. Kugathasan   +28 more
semanticscholar   +1 more source

Pharmacokinetic‐pharmacodynamic modelling of risankizumab using chronic plaque psoriasis real‐world data

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Risankizumab is a high‐cost biologic treatment for chronic plaque psoriasis, an immune‐mediated inflammatory disease presenting with painful red scaly skin lesions. Inter‐individual heterogeneity in treatment response may be better addressed with personalised rather than fixed dosing. We sought to develop a pharmacokinetic/pharmacodynamic (
Charlotte M. Thomas, Jessica Ruoheng Wei, David Baudry, Zehra Arkir, Bola Coker, Tejus Dasandi, Kingsley Powell, Monica Arenas‐Hernandez, Jenny Leung, Krystal Rawstron, Chioma Nwaogu, Richard Woolf, Andrew E. Pink, Jonathan Barker, Joseph F. Standing, Catherine H. Smith, Satveer K. Mahil   +16 more
wiley   +1 more source

Detecting and managing small bowel Crohn’s disease – capsule endoscopy becoming a first line diagnostic method?

, 2011
Small bowel endoscopy is crucial for diagnosing small bowel Crohn’s disease, and capsule endoscopy is complemented by balloon-assisted enteroscopy to take biopsies and by magnetic resonance imaging to visualize enteral and extra-intestinal involvement ...
Hausmann, Johannes, Albert, Jörg Gerhard   +1 more
core   +1 more source

Treatment of metastatic cutaneous Crohn disease with certolizumab [PDF]

, 2015
Metastatic Crohn disease is a rare cutaneous manifestation of Crohn disease characterized by granulomatous lesions discontinuous with the diseased areas of the gastrointestinal tract.
Wildman, Horatio, Adhami, Katayun, Camp, Brendan, Kiuru, Maija, Jacob, Vinita, Magro, Cynthia   +5 more
core   +1 more source

Pulmonary Crohn’s Disease or Crohn’s Disease with Lung Sarcoidosis? A Case Report and Literature Review

, 2022
Background: Crohn’s disease and ulcerative hemorrhagic colitis are forms of granulomatous inflammatory intestinal disease, which usually affects the gastrointestinal tract.
Camelia Cristina Diaconu, Bădărău, Ioana Anca, Cornel Adrian Petreanu, Iulian-Vasile Antoniac, Cornel Savu, Horațiu Moldovan, Andrei Bobocea, Vlăsceanu, Silviu, Moldovan, Horațiu, Savu, Cornel, Diaconu, Camelia Cristina, Silviu Vlăsceanu, Daniela Gheorghiță, Petreanu, Cornel Adrian, Mirea, Liliana, Ioana Anca Bădărău, Gheorghiță, Daniela, Liliana Mirea, Bobocea, Andrei, Antoniac, Iulian-Vasile   +19 more
core   +1 more source

Is It Crohn’s Disease? [PDF]

Gastroenterology, 2020
Parigi, Tommaso Lorenzo, Bonifacio, Cristiana, Danese, Silvio   +2 more
openaire   +2 more sources

A specific gene-microbe interaction drives the development of Crohn’s disease–like colitis in mice

Science immunology, 2019
Combined deficiency of NOD2 and NAPDH oxidase triggers Crohn’s-like disease driven by a mouse pathobiont, Mucispirillum. A mouse model for Crohn’s disease Although several mouse models of inflammatory bowel disease exist, Crohn’s disease has been ...
Roberta Caruso, T. Mathes, Eric C. Martens, Nobuhiko Kamada, Asma Nusrat, N. Inohara, G. Nuñez   +6 more
semanticscholar   +1 more source