Results 71 to 80 of about 15,981,489 (330)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Mild Clinical Behaviour of Crohn Disease in Elderly Patients in a Latin American Country: A Case-Control Study

Canadian Journal of Gastroenterology and Hepatology, 2015
BACKGROUND: Crohn disease is characterized by fluctuating clinical behaviour, which is influenced by various factors. There are no data from Latin America that evaluate the clinical behaviour of Crohn disease in elderly patients.
Jesús K Yamamoto-Furusho, Andrea Sarmiento-Aguilar   +1 more
doaj   +1 more source

Autophagy and Crohn's Disease [PDF]

Journal of Innate Immunity, 2013
Advances in genetics have shed light on the molecular basis of Crohn's disease (CD) predisposition and pathogenesis, via linkage disequilibrium analysis to genome-wide association studies. The discovery of genetic variants of <i>NOD2</i>, an intracellular pathogen molecular sensor, as risk factors for CD has paved the way for further ...
Hang Thi Thu Nguyen, -, Lapaquette, Pierre, Bringer, Marie-Agnès, Darfeuille-Michaud, Arlette   +3 more
openaire   +4 more sources

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Capsule endoscopy in the diagnosis of Crohn’s disease

Medical Devices: Evidence and Research, 2013
Yaron NivDepartment of Gastroenterology, Rabin Medical Center, Tel Aviv University, Petah Tikva, IsraelAbstract: Crohn’s disease is a chronic inflammatory disorder affecting any part of the gastrointestinal tract, but frequently involves the small ...
Niv Y
doaj  

Crohn’s disease as an immunodeficiency [PDF]

Expert Review of Clinical Immunology, 2010
The pathogenesis of Crohn's disease (CD) has widely been regarded as the consequence of a dysregulated T-cell-mediated response to intestinal microbes, and the majority of the worldwide research effort has focused on characterizing and treating the chronic inflammatory phase of the disease.
Arkwright, Peter; id_orcid 0000-0002-7411-5375, Hayee, Bu'Hussain, Rahman, Farooq Z., Sewell, Gavin, Smith, Andrew M., Segal, Anthony W.   +5 more
openaire   +2 more sources

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease [PDF]

, 2005
Recent data suggest that polymorphisms in the organic cation transporter (OCTN) genes OCTN1 (SLC22A4) and OCTN2 (SLC22A5) represent disease-causing mutations within the IBD5 locus (chromosome 5q31).
Tenesa, Albert, Anderson, Norman, Satsangi, Jack, Nimmo, Elaine R, Drummond, Hazel, Ho, Gwo-Tzer, Arnott, Ian D R, Noble, Colin L, Smith, Linda   +8 more
core   +1 more source

Analysis of current status and influencing factors of opportunistic infections in Crohn disease

Neike lilun yu shijian
ObjectiveTo explore the current status and influencing factors of opportunistic infections in Crohn disease. MethodsData on demographic characteristics, disease features, treatment regimens and laboratory results of 369 patients with Crohn disease ...
Hui CAI, Yousheng LI, Yuhua HUANG, Jingjing XU, Qingfen LIU, Fen GU   +5 more
doaj   +1 more source

Meta-Analysis Increases to 71 the Tally of Confirmed Crohn’s Disease Susceptibility Loci

Nature Genetics, 2010
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent ...
A. Franke, D. McGovern, J. Barrett, Kai Wang, G. L. Radford-Smith, T. Ahmad, C. Lees, Tobias C. Balschun, J. Lee, R. Roberts, C. Anderson, J. Bis, S. Bumpstead, D. Ellinghaus, Eleonora A. M. Festen, M. Georges, T. Green, T. Haritunians, L. Jostins, A. Latiano, C. Mathew, G. Montgomery, N. Prescott, S. Raychaudhuri, J. I. Rotter, P. Schumm, Y. Sharma, L. Simms, K. Taylor, David C. Whiteman, C. Wijmenga, R. Baldassano, M. Barclay, T. M. Bayless, S. Brand, C. Büning, Albert Cohen, J. Colombel, M. Cottone, L. Stronati, T. Denson, M. De Vos, R. d'Inca, M. Dubinsky, C. Edwards, T. Florin, D. Franchimont, R. Gearry, J. Glas, A. Van Gossum, S. Guthery, J. Halfvarson, H. Verspaget, J. Hugot, Amir S Karban, D. Laukens, I. Lawrance, M. Lémann, A. Levine, C. Libioulle, Edouard Louis, C. Mowat, William G. Newman, J. Panés, A. Phillips, D. Proctor, M. Regueiro, Richard Russell, P. Rutgeerts, J. Sanderson, M. Sans, F. Seibold, A. Steinhart, P. Stokkers, L. Törkvist, G. Kullak-Ublick, David C. Wilson, T. Walters, S. Targan, S. Brant, J. Rioux, M. D'Amato, R. Weersma, S. Kugathasan, A. Griffiths, J. Mansfield, S. Vermeire, R. Duerr, M. Silverberg, J. Satsangi, S. Schreiber, Judy H. Cho, V. Annese, H. Hakonarson, M. Daly, M. Parkes   +95 more
semanticscholar   +1 more source