Results 71 to 80 of about 10,462,861 (343)

NOD2/CARD15 gene influences disease behaviour but not IBD susceptibility in a Moroccan population

The Turkish Journal of Gastroenterology, 2014
Background/Aims: IBD (Crohn’s disease and Ulcerative Colitis) is chronic and multifactorial disease of the gastrointestinal tract. Till now, his pathogenesis remains unclear.
Nadia Serbati, Wafaa Badre, Brehima Diakite, Sellama Nadifi   +3 more
doaj   +1 more source

Autophagy and Crohn's Disease [PDF]

Journal of Innate Immunity, 2013
Advances in genetics have shed light on the molecular basis of Crohn's disease (CD) predisposition and pathogenesis, via linkage disequilibrium analysis to genome-wide association studies. The discovery of genetic variants of <i>NOD2</i>, an intracellular pathogen molecular sensor, as risk factors for CD has paved the way for further ...
Hang Thi Thu Nguyen, -, Lapaquette, Pierre, Bringer, Marie-Agnès, Darfeuille-Michaud, Arlette   +3 more
openaire   +4 more sources

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Nature Genetics, 2008
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out
J. Barrett, S. Hansoul, Dan L. Nicolae, Judy H. Cho, R. Duerr, J. Rioux, J. Rioux, S. Brant, M. Silverberg, K. Taylor, M. Barmada, A. Bitton, T. Dassopoulos, L. Datta, Todd Green, A. Griffiths, E. Kistner, M. Murtha, M. Regueiro, J. Rotter, L. Schumm, A. Steinhart, S. Targan, R. Xavier, C. Libioulle, C. Sandor, M. Lathrop, J. Belaiche, O. Dewit, I. Gut, S. Heath, D. Laukens, M. Mni, P. Rutgeerts, A. Gossum, D. Zélénika, D. Franchimont, J. Hugot, M. Vos, S. Vermeire, E. Louis, L. Cardon, C. Anderson, H. Drummond, E. Nimmo, T. Ahmad, N. Prescott, Clive M. Onnie, S. Fisher, J. Marchini, J. Ghori, S. Bumpstead, R. Gwilliam, M. Tremelling, P. Deloukas, J. Mansfield, D. Jewell, J. Satsangi, C. Mathew, M. Parkes, M. Georges, M. Daly, M. Daly   +62 more
semanticscholar   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Mild Clinical Behaviour of Crohn Disease in Elderly Patients in a Latin American Country: A Case-Control Study

Canadian Journal of Gastroenterology and Hepatology, 2015
BACKGROUND: Crohn disease is characterized by fluctuating clinical behaviour, which is influenced by various factors. There are no data from Latin America that evaluate the clinical behaviour of Crohn disease in elderly patients.
Jesús K Yamamoto-Furusho, Andrea Sarmiento-Aguilar   +1 more
doaj   +1 more source

Computed tomography enterography and magnetic resonance enterography in small intestine of Crohn's disease

Journal of Coloproctology, 2017
Crohn disease is defined as a chronic inflammatory and idiopathic process that can affect any portion of the gastrointestinal tract. The small intestine is the most frequently affected place, so small bowel morphology investigation is often mandatory.For
Aida Cristina Correia Oliveira Azevedo, Sandra Fátima Fernandes Martins   +1 more
doaj   +1 more source

Analysis of IL12B gene variants in inflammatory bowel disease [PDF]

, 2012
IL12B encodes the p40 subunit of IL-12, which is also part of IL-23. Recent genome-wide association studies identified IL12B and IL23R as susceptibility genes for inflammatory bowel disease (IBD).
Darina Czamara, Seiderer, J., Seiderer Julia, Ochsenkühn, Thomas, Fries, C., Julia Seiderer (107820), Beigel, F., Wagner, Johanna, Glas, J., Cornelia Tillack (174718), Friedrich, Matthias, Christian Steib (174731), Czamara, D., Diegelmann Julia, Jürgen Glas (107816), Fries Christoph, Tillack, Cornelia, Friedrich Matthias, Steib Christian, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Göke, B., Florian Beigel (174724), Brand Stephan, Thomas Ochsenkühn, Olszak Torsten, Beigel, Florian, Matthias Friedrich (174721), Thomas Ochsenkühn (174734), Stallhofer, J., Ochsenkühn, T., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Cornelia Tillack, Julia Diegelmann, Beigel Florian, Steib, Christian, Göke, Burkhard, Wetzke Martin, Fries, Christoph, Wagner, J., Friedrich, M., Seiderer, Julia, Glas, Jürgen, Diegelmann, J., Burkhard Göke (109829), Christoph Fries, Ochsenkühn Thomas, Wagner Johanna, Martin Wetzke, Burkhard Göke, Göke Burkhard, Christian Steib, Stephan Brand, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Stallhofer Johannes, Julia Diegelmann (107830), Jürgen Glas, Johanna Wagner (174709), Tillack Cornelia, Johanna Wagner, Wetzke, Martin, Czamara Darina, Diegelmann, Julia, Christoph Fries (174714), Johannes Stallhofer (174728), Glas Jürgen, Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten, Tillack, C.   +79 more
core   +1 more source

Machine Learning Model in Predicting Sarcopenia in Crohn’s Disease Based on Simple Clinical and Anthropometric Measures

, 2022
Sarcopenia is associated with increased morbidity and mortality in Crohn’s disease. The present study is aimed at investigating the different diagnostic performance of different machine learning models in identifying sarcopenia in Crohn’s ...
Zhongguang Luo, Shaocong Mo, Yanwei Zeng, Jie Liu, Lan Rong, Feifei Luo, Yujen Tseng, Wanwei Zheng, Bing Zhong, Huan Song   +9 more
core   +1 more source

Crohn’s disease as an immunodeficiency [PDF]

Expert Review of Clinical Immunology, 2010
The pathogenesis of Crohn's disease (CD) has widely been regarded as the consequence of a dysregulated T-cell-mediated response to intestinal microbes, and the majority of the worldwide research effort has focused on characterizing and treating the chronic inflammatory phase of the disease.
Arkwright, Peter; id_orcid 0000-0002-7411-5375, Hayee, Bu'Hussain, Rahman, Farooq Z., Sewell, Gavin, Smith, Andrew M., Segal, Anthony W.   +5 more
openaire   +2 more sources

Long‐Term Outcomes After Stoma Creation in Crohn's Disease: A Retrospective Cohort Study of 422 Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Stoma creation is often required in Crohn's disease (CD), most commonly because of progressive anorectal disease. As stoma closure strongly influences long‐term quality of life and surgical decision‐making, this study evaluated the indications and long‐term outcomes of stoma creation in patients with CD.
Kentaro Nagano, Ryuichi Kuwahara, Yusuke Tomoo, Kurando Kusunoki, Yuki Horio, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Motoi Uchino, Hiroki Ikeuchi   +9 more
wiley   +1 more source