Results 61 to 70 of about 15,981,489 (330)

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Oral Crohn′s disease without intestinal manifestations

Journal of Pharmacy and Bioallied Sciences, 2012
Crohn′s disease is a granulomatous inflammatory bowel disease and was described in 1932 as a chronic granulomatous disorder of the terminal ileum and is now considered a distinct member of the inflammatory bowel disease family.
Gingisetty Harikishan, Nagate Raghavendra Reddy, Harikrishnan Prasad, Subappa Anitha   +3 more
doaj   +1 more source

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Nature Genetics, 2008
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out
J. Barrett, S. Hansoul, D. Nicolae, Judy H. Cho, R. Duerr, J. Rioux, S. Brant, M. Silverberg, K. Taylor, M. Barmada, A. Bitton, T. Dassopoulos, L. Datta, T. Green, A. Griffiths, E. Kistner, Michael T. Murtha, M. Regueiro, J. Rotter, L. Schumm, A. Steinhart, S. Targan, R. Xavier, C. Libioulle, C. Sandor, M. Lathrop, J. Belaiche, O. Dewit, I. Gut, S. Heath, D. Laukens, M. Mni, P. Rutgeerts, A. Van Gossum, D. Zélénika, D. Franchimont, J. Hugot, M. De Vos, S. Vermeire, E. Louis, L. Cardon, C. Anderson, H. Drummond, E. Nimmo, T. Ahmad, N. Prescott, Clive M. Onnie, S. Fisher, J. Marchini, J. Ghori, S. Bumpstead, R. Gwilliam, M. Tremelling, P. Deloukas, J. Mansfield, D. Jewell, J. Satsangi, C. Mathew, M. Parkes, M. Georges, Mark J. Daly   +60 more
semanticscholar   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Quality of life in children with crohn disease

, 2010
Objectives: Quality of life (QOL) is reportedly poor in children with Crohn disease (CD) but improves with increasing disease duration. This article aims to detail QOL in a cohort of Australian children with CD in relation to disease duration, disease ...
Grange, I., Cleghorn, Geoffrey J., Connor, F. L., Cleghorn, G. J., Ee, L., Withers, G. D., Davies, P. S. W., Hill, R. J., Lewindon, P. J., Muir, R., Ee, L. C., PSW Davies, RJ Hill, LC Ee, I Grangé, R Muir, GJ Cleghorn, FL Connor, GD Withers, PJ Lewindon   +19 more
core   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

NOD2/CARD15 gene influences disease behaviour but not IBD susceptibility in a Moroccan population

The Turkish Journal of Gastroenterology, 2014
Background/Aims: IBD (Crohn’s disease and Ulcerative Colitis) is chronic and multifactorial disease of the gastrointestinal tract. Till now, his pathogenesis remains unclear.
Nadia Serbati, Wafaa Badre, Brehima Diakite, Sellama Nadifi   +3 more
doaj   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

Computed tomography enterography and magnetic resonance enterography in small intestine of Crohn's disease

Journal of Coloproctology, 2017
Crohn disease is defined as a chronic inflammatory and idiopathic process that can affect any portion of the gastrointestinal tract. The small intestine is the most frequently affected place, so small bowel morphology investigation is often mandatory.For
Aida Cristina Correia Oliveira Azevedo, Sandra Fátima Fernandes Martins   +1 more
doaj   +1 more source

Is It a Crohn’s Disease? [PDF]

Gastroenterology, 2021
Jun-Yan, Qu, Zhen, Li
openaire   +2 more sources