Results 61 to 70 of about 10,462,861 (343)

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Oral Crohn′s disease without intestinal manifestations

Journal of Pharmacy and Bioallied Sciences, 2012
Crohn′s disease is a granulomatous inflammatory bowel disease and was described in 1932 as a chronic granulomatous disorder of the terminal ileum and is now considered a distinct member of the inflammatory bowel disease family.
Gingisetty Harikishan, Nagate Raghavendra Reddy, Harikrishnan Prasad, Subappa Anitha   +3 more
doaj   +1 more source

A role for vimentin in Crohn disease

, 2012
Crohn disease (CD), one of the major chronic inflammatory bowel diseases, occurs anywhere in the gastrointestinal tract with discontinuous transmural inflammation.
Wilson, David C., Stevens, Craig, Satsangi, Jack, Henderson, Paul   +3 more
core   +1 more source

Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. [PDF]

, 2010
Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of
Seiderer, J., Seiderer Julia, Folwaczny, M., Ochsenkühn, Thomas, Fries, C., Beigel, F., Klein, Wolfram, Glas, J., Müller-Myhsok, B., Folwaczny Matthias, Darina Roeske, Matthias Folwaczny, Bertram Müller-Myhsok, Göke, Burkard, Jörg T Epplen, Epplen Jörg T., Diegelmann Julia, Fries Christoph, Melinda Nagy, Pfennig Simone, Brand, Stephan, Nagy, M., Göke, B., Brand Stephan, Nagy, Melinda, Thomas Ochsenkühn, Weidinger Maria, Beigel, Florian, Weidinger, Maria, Ochsenkühn, T., Klein, Wolfgang, Epplen, Jörg T., Julia Diegelmann, Beigel Florian, Müller-Myhsok Bertram, Göke, Burkhard, Fries, Christoph, Folwaczny, Matthias, Pfennig, S., Pfennig, Simone, Peter Lohse, Seiderer, Julia, Roeske, Darina, Glas, Jürgen, Epplen, J., Diegelmann, J., Lohse, P., Christoph Fries, Ochsenkühn Thomas, Müller-Myhsok, Bertram, Weidinger, M., Burkhard Göke, Göke Burkhard, Klein, W., Stephan Brand, Maria Weidinger, Roeske Darina, Brand, S., Jürgen Glas, Klein Wolfram, Roeske, D., Lohse, Peter, Diegelmann, Julia, Nagy Melinda, Simone Pfennig, Wolfram Klein, Glas Jürgen, Florian Beigel, Lohse Peter, Julia Seiderer   +69 more
core   +1 more source

Malassezia is Associated with Crohn’s Disease and Exacerbates Colitis in Mouse Models

Cell Host and Microbe, 2019
SUMMARY Inflammatory bowel disease (IBD) is characterized by alterations in the intestinal microbiota and altered immune responses to gut microbiota. Evidence is accumulating that IBD is influenced by not only commensal bacteria but also commensal fungi.
Jose J. Limon, Jie Tang, Dalin Li, Andrea J. Wolf, K. Michelsen, V. Funari, Matthew D Gargus, Christopher Nguyen, Purnima Sharma, Viviana I Maymi, I. Iliev, J. Skalski, Jordan Brown, C. Landers, J. Borneman, J. Braun, S. Targan, D. McGovern, D. Underhill   +18 more
semanticscholar   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

A Complicated Thread: Abdominal Actinomycosis in a Young Woman with Crohn Disease

Case Reports in Gastroenterology, 2017
Crohn disease is a chronic inflammatory condition that primarily affects the gastrointestinal tract. Typical manifestations include fever, weight loss, fatigue, and abdominal pain, and abdominal abscesses and fistulae are frequent complications ...
Ari Nahum, Gregory Filice, Ashish Malhotra   +2 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Patients with Crohn's disease on anti-tumor necrosis factor therapy are at significant risk of inadequate response to the 23-valent pneumococcal polysaccharide vaccine

, 2018
Crohn's disease; Immunosuppressive agents; Inflammatory bowel disease; Pneumococcal ...
정성애
core   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source