Results 41 to 50 of about 15,981,489 (330)

ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment.

Journal of Crohn's & Colitis
One trial involving 105 patients reported on induction of clinical response 29 . Clinical response was more common in patients receiving methylprednisolone as compared with placebo [93.6% vs. 53.4%; RR: 1.75; 95% CI: 1.36–2.25].
H. Gordon, Silvia Minozzi, U. Kopylov, B. Verstockt, María Chaparro, C. Buskens, J. Warusavitarne, M. Agrawal, M. Allocca, R. Atreya, R. Battat, D. Bettenworth, G. Bislenghi, Steven Ross Brown, J. Burisch, M. Casanova, W. Czuber-Dochan, J. de Groof, A. El-Hussuna, P. Ellul, C. Fidalgo, G. Fiorino, J. Gisbert, J. Sabino, J. Hanžel, S. Holubar, M. Iacucci, N. Iqbal, C. Kapizioni, K. Karmiris, Taku Kobayashi, P. G. Kotze, G. Luglio, C. Maaser, G. Moran, N. Noor, K. Papamichail, G. Peros, C. Reenaers, G. Sica, R. Sigall-Boneh, S. Vavricka, H. Yanai, P. Myrelid, M. Adamina, T. Raine   +45 more
semanticscholar   +1 more source

ECCO Guidelines on Therapeutics in Crohn's Disease: medical treatment.

Journal of Crohn's & Colitis, 2019
This article is the second in a series of two publications relating to the European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn’s disease.
J. Torres, S. Bonovas, Glen Doherty, T. Kucharzik, J. Gisbert, T. Raine, M. Adamina, A. Armuzzi, Oliver Bachmann, P. Bager, L. Biancone, B. Bokemeyer, P. Bossuyt, J. Burisch, Paul Collins, A. El-Hussuna, P. Ellul, Cornelia Frei-Lanter, F. Furfaro, C. Gingert, P. Gionchetti, F. Gomollón, Marien González-Lorenzo, Hannah Gordon, T. Hlavatý, P. Juillerat, Konstantinos Katsanos, U. Kopylov, E. Krustiņš, T. Lytras, C. Maaser, F. Magro, J. Marshall, P. Myrelid, Gianluca Pellino, I. Rosa, J. Sabino, E. Savarino, A. Spinelli, L. Stassen, M. Uzzan, S. Vavricka, B. Verstockt, J. Warusavitarne, O. Zmora, G. Fiorino   +45 more
semanticscholar   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Anorexia Nervosa Complicating Pediatric Crohn Disease—Case Report and Literature Review

Frontiers in Pediatrics, 2018
Crohn disease and anorexia nervosa share common symptoms of weight loss and reduced oral intake. The prevalence of both disorders has increased over time.
Aedin Collins, Elizabeth Nolan, Michelle Hurley, Antoinette D'Alton, Séamus Hussey, Séamus Hussey, Séamus Hussey, Séamus Hussey   +7 more
doaj   +1 more source

ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment.

Journal of Crohn's & Colitis
This article is the second in a series of two publications on the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's disease.
M. Adamina, Silvia Minozzi, J. Warusavitarne, C. Buskens, María Chaparro, B. Verstockt, U. Kopylov, M. Agrawal, M. Allocca, R. Atreya, R. Battat, D. Bettenworth, G. Bislenghi, Steven Ross Brown, J. Burisch, M. Casanova, W. Czuber-Dochan, J. de Groof, A. El-Hussuna, P. Ellul, C. Fidalgo, G. Fiorino, J. Gisbert, J. Sabino, J. Hanžel, S. Holubar, M. Iacucci, N. Iqbal, C. Kapizioni, K. Karmiris, Taku Kobayashi, P. G. Kotze, G. Luglio, C. Maaser, G. Moran, N. Noor, K. Papamichail, G. Peros, C. Reenaers, G. Sica, R. Sigall-Boneh, S. Vavricka, H. Yanai, T. Raine, H. Gordon, P. Myrelid   +45 more
semanticscholar   +1 more source

Crohn's disease

The Lancet, 2012
Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the gastrointestinal tract with extraintestinal manifestations and associated immune disorders. Genome wide association studies identified susceptibility loci that--triggered by environmental factors--result in a disturbed innate (ie, disturbed intestinal barrier, Paneth ...
Baumgart, Daniel C, Sandborn, William J
openaire   +2 more sources

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Evaluation of the laryngeal involvement and voice quality in crohn disease

B-ENT, 2020
Objective: A few cases of laryngeal involvement have been reported for Crohn disease. However, laryngeal involvement may be greater than expected. This study aimed to evaluate the laryngeal involvement and voice quality in patients with Crohn disease ...
Hüseyin Sarı, Ziya Saltürk, Tolgar Lütfi Kumral, Yasemin Gökden, Ayşe Enise Göker, Ayça Başkadem Yılmazer   +5 more
doaj   +3 more sources

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source