Results 41 to 50 of about 10,462,861 (343)

Lacrimal Gland Enlargement as an Extraintestinal Manifestation of Crohn Disease: A Case Report

Annals of Internal Medicine: Clinical Cases, 2022
A 29-year-old woman was referred for a 3-month history of recurrent fever, abdominal pain, and diarrhea. Abdominal computed tomography (CT) scans revealed diffuse intestinal wall thickening involving the transverse colon. When her abdominal pain recurred
Ayaka Takahara, Kiyoshi Shikino
doaj   +1 more source

Surgical Management in Enterovesical Fistula in Crohn Disease at a Single Medical Center

, 2017
Crohn disease is a chronic, transmural, inflammatory disease of the gastrointestinal tract with unknown etiology. It can affect any part of the gastrointestinal tract and may cause fistula, stricture, or abscess formation with disease progression.
Su, Yann-Rong;Shih, I-Lun;Tai, Huai-Ching;Wei, Shu-Chen;Lin, Been-Ren;Yu, Hong-Jeng;Huang, Chao-Yuan, 戴槐青;蘇彥榮;余宏政;黃昭淵;魏淑?;施怡倫;林本仁   +1 more
core   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease

, 2005
Recent data suggest that polymorphisms in the organic cation transporter (OCTN) genes OCTN1 (SLC22A4) and OCTN2 (SLC22A5) represent disease-causing mutations within the IBD5 locus (chromosome 5q31).
Arnott, IDR, Tenesa, Albert, Tenesa, A, Anderson, Norman, Satsangi, Jack, Anderson, N, Nimmo, Elaine R, Satsangi, J, Drummond, Hazel, Ho, Gwo-Tzer, Arnott, Ian D R, Noble, Colin L, Smith, Linda, Ho, G-T, Nimmo, ER, Noble, CL, Smith, L, Drummond, H   +17 more
core   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

ECCO Guidelines on Therapeutics in Crohn's Disease: medical treatment.

Journal of Crohn's & Colitis, 2019
This article is the second in a series of two publications relating to the European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn’s disease.
J. Torres, S. Bonovas, Glen Doherty, T. Kucharzik, J. Gisbert, T. Raine, M. Adamina, A. Armuzzi, Oliver Bachmann, P. Bager, L. Biancone, B. Bokemeyer, P. Bossuyt, J. Burisch, Paul Collins, A. El‐Hussuna, P. Ellul, Cornelia Frei-Lanter, F. Furfaro, C. Gingert, P. Gionchetti, F. Gomollón, Marien González-Lorenzo, Hannah Gordon, T. Hlavatý, P. Juillerat, Konstantinos Katsanos, U. Kopylov, E. Krustiņš, T. Lytras, C. Maaser, F. Magro, John Kenneth Marshall, P. Myrelid, Gianluca Pellino, I. Rosa, J. Sabino, E. Savarino, A. Spinelli, Laurents P. S. Stassen, Mathieu Uzzan, S. Vavricka, B. Verstockt, J. Warusavitarne, O. Zmora, G. Fiorino   +45 more
semanticscholar   +1 more source

Crohn's disease

The Lancet, 2012
Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the gastrointestinal tract with extraintestinal manifestations and associated immune disorders. Genome wide association studies identified susceptibility loci that--triggered by environmental factors--result in a disturbed innate (ie, disturbed intestinal barrier, Paneth ...
Baumgart, Daniel C, Sandborn, William J
openaire   +2 more sources

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Anorexia Nervosa Complicating Pediatric Crohn Disease—Case Report and Literature Review

Frontiers in Pediatrics, 2018
Crohn disease and anorexia nervosa share common symptoms of weight loss and reduced oral intake. The prevalence of both disorders has increased over time.
Aedin Collins, Elizabeth Nolan, Michelle Hurley, Antoinette D'Alton, Séamus Hussey, Séamus Hussey, Séamus Hussey, Séamus Hussey   +7 more
doaj   +1 more source

Clinical presentation of Crohn's disease. Association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery

, 2005
Background/Aims: Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically ...
Gasztonyi, Beáta, Kovács, Attila, Figler, Mária, Szalay, Ferenc, Cseh, J., Mikó, Éva, Horváth, Gábor, Szekeres Barthó, J., Papp, János, Lakatos, Péter László, Molnár, Tamás, Kovács, Ágota, Lakatos, Péter, Hunyady, Béla, Tulassay, Zsolt, Kisbenedek, A. G., Lakatos, László   +16 more
core   +1 more source