Results 31 to 40 of about 10,462,861 (343)

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn disease susceptibility

Nature Genetics, 2007
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci.
M. Parkes, J. Barrett, N. Prescott, M. Tremelling, C. Anderson, S. Fisher, R. Roberts, E. Nimmo, Fraser Cummings, D. Soars, H. Drummond, C. Lees, S. Khawaja, R. Bagnall, D. Burke, Catherine E. Todhunter, Tariq Ahmad, Clive M. Onnie, W. McArdle, D. Strachan, G. Bethel, C. Bryan, C. Lewis, P. Deloukas, A. Forbes, J. Sanderson, D. Jewell, J. Satsangi, J. Mansfield, L. Cardon, C. Mathew   +30 more
semanticscholar   +1 more source

Leukocytoclastic Vasculitis in a Patient With Crohn Disease: A Case Report

Journal of Investigative Medicine High Impact Case Reports, 2023
Leukocytoclastic vasculitis (LCV) is an idiopathic small vessel vasculitis. Leukocytoclastic vasculitis can be found in a spectrum of diseases and is noted as a rare extraintestinal manifestation of Crohn disease.
Mark Daniele Bugada BS, Vamsi K. Emani MD   +1 more
doaj   +1 more source

The treatment-naive microbiome in new-onset Crohn's disease.

Cell Host and Microbe, 2014
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), are genetically linked to host pathways that implicate an underlying role for aberrant immune responses to intestinal microbiota.
D. Gevers, S. Kugathasan, L. Denson, Y. Vázquez-Baeza, William W. Van Treuren, Boyu Ren, Emma H. Schwager, D. Knights, S. Song, Moran Yassour, X. Morgan, A. Kostic, Chengwei Luo, Antonio Gonzalez, Daniel McDonald, Y. Haberman, T. Walters, S. Baker, J. Rosh, Michael C. Stephens, M. Heyman, J. Markowitz, R. Baldassano, A. Griffiths, F. Sylvester, D. Mack, Sandra C. Kim, W. Crandall, J. Hyams, C. Huttenhower, R. Knight, R. Xavier   +31 more
semanticscholar   +1 more source

Research progress on risk factors for anastomotic recurrence after Crohn disease [PDF]

Yixue xinzhi zazhi, 2023
Intestinal resection and reconstruction are crucial steps in surgical treatment for Crohn disease. However, anastomotic recurrence is a common complication following reconstruction surgery.
Bao-Jia YAO, Li-Chao YANG, Qiang WU, Gang-Lei LIU   +3 more
doaj   +1 more source

ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment.

Journal of Crohn's & Colitis, 2019
This article is the second in a series of two publications relating to the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's disease.
M. Adamina, S. Bonovas, T. Raine, A. Spinelli, J. Warusavitarne, A. Armuzzi, O. Bachmann, P. Bager, L. Biancone, B. Bokemeyer, P. Bossuyt, J. Burisch, P. Collins, G. Doherty, A. El‐Hussuna, P. Ellul, G. Fiorino, C. Frei-Lanter, F. Furfaro, C. Gingert, P. Gionchetti, J. Gisbert, F. Gomollón, Marien González Lorenzo, H. Gordon, T. Hlavatý, P. Juillerat, K. Katsanos, U. Kopylov, E. Krustiņš, T. Kucharzik, T. Lytras, C. Maaser, F. Magro, J. K. Marshall, P. Myrelid, Gianluca Pellino, I. Rosa, J. Sabino, E. Savarino, L. Stassen, J. Torres, Mathieu Uzzan, S. Vavricka, B. Verstockt, O. Zmora   +45 more
semanticscholar   +1 more source

Chronic linear ulcerations of the inguino-crural and buttocks folds

Indian Journal of Dermatology, 2011
Vulvo-perineal Crohn′s disease is a rare condition either when it is isolated or associated with digestive manifestations. In the former condition named metastatic Crohn′s disease, it may constitute a diagnostic challenge and may be confused especially ...
Aida Khaled, Nadia Ezzine-Sebai, Becima Fazaa, Faten Zeglaoui, Rachida Zermani, Mohamed Ridha Kamoun   +5 more
doaj   +1 more source

Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel Disease-specific Transcriptomic Signatures

Gastro Hep Advances, 2023
Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier.
Tatiana A. Karakasheva, Yusen Zhou, Hongbo M. Xie, Gloria E. Soto, Tiana D. Johnson, Madison A. Stoltz, Daana M. Roach, Noor Nema, Chizoba N. Umeweni, Kaitlyn Naughton, Lauren Dolinsky, James A. Pippin, Andrew D. Wells, Struan F.A. Grant, Louis Ghanem, Natalie Terry, Amanda B. Muir, Kathryn E. Hamilton   +17 more
doaj   +1 more source

Investigation of IL23R, JAK2, and STAT3 gene polymorphisms and gene–gene interactions in Crohn’s disease and ulcerative colitis in a Turkish population

The Turkish Journal of Gastroenterology, 2016
Background/Aims: Inflammatory bowel diseases are chronic, relapsing, inflammatory conditions. They have a genetic backround resulting in patient susceptibility.
Güray Can, Ahmet Tezel, Hakan Gürkan, Hilmi Tozkır, Gülbin Ünsal, Ali Rıza Soylu, Hasan Celalettin Ümit   +6 more
doaj   +1 more source

Pathophysiology of Crohn’s disease inflammation and recurrence

Biology Direct, 2020
Chron’s Disease is a chronic inflammatory intestinal disease, first described at the beginning of the last century. The disease is characterized by the alternation of periods of flares and remissions influenced by a complex pathogenesis in which ...
L. Petagna, A. Antonelli, C. Ganini, V. Bellato, M. Campanelli, A. Divizia, C. Efrati, M. Franceschilli, A. Guida, S. Ingallinella, F. Montagnese, B. Sensi, L. Siragusa, Giuseppe S. Sica   +13 more
semanticscholar   +1 more source

Cryptogenic Organizing Pneumonia With Lung Nodules Secondary to Pulmonary Manifestation of Crohn Disease

Clinical Medicine Insights: Case Reports, 2017
Crohn disease is an immune-mediated inflammatory condition with gastrointestinal and extraintestinal manifestations in patients. Pulmonary involvement of Crohn disease is one manifestation.
Taufiq Zaman, Joseph Watson, Mohammad Zaman   +2 more
doaj   +1 more source