Results 51 to 60 of about 15,981,489 (330)

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source

Clinical epidemiology and phenotypic characteristics of Crohn′s disease in the central region of Saudi Arabia

The Saudi Journal of Gastroenterology, 2014
Background/Aims: Despite the remarkable increase in the incidence of Crohn′s disease among Saudis in recent years, data about Crohn′s disease in Saudi Arabia are scarce.
Abdulrahman M. Aljebreen, Othman R. Alharbi, Nahla A. Azzam, Ahmed S. Almalki, Khalid A. Alswat, Majid A. Almadi   +5 more
doaj   +1 more source

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The bacteria that live within the human gut play crucial roles in regulating our primary metabolism, protecting us from pathogens, and developing our immune system.
Matthew T. Henke, Douglas J. Kenny, Chelsi D. Cassilly, H. Vlamakis, R. Xavier, J. Clardy   +5 more
semanticscholar   +1 more source

Telocytes in Crohn's disease [PDF]

Journal of Cellular and Molecular Medicine, 2013
AbstractCrohn's disease (CD) is a relapsing chronic inflammatory disorder that may involve all the gastrointestinal tract with a prevalence of terminal ileum. Intestinal lesions have a characteristic discontinuous and segmental distribution and may affect all layers of the gut wall.
A. F. Milia, RUFFO, MARTINA, MANETTI, MIRKO, ROSA, IRENE, D. Conte, FAZI, MARILENA, MESSERINI, LUCA, IBBA, LIDIA   +7 more
openaire   +3 more sources

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A Complicated Thread: Abdominal Actinomycosis in a Young Woman with Crohn Disease

Case Reports in Gastroenterology, 2017
Crohn disease is a chronic inflammatory condition that primarily affects the gastrointestinal tract. Typical manifestations include fever, weight loss, fatigue, and abdominal pain, and abdominal abscesses and fistulae are frequent complications ...
Ari Nahum, Gregory Filice, Ashish Malhotra   +2 more
doaj   +1 more source

Malassezia is Associated with Crohn’s Disease and Exacerbates Colitis in Mouse Models

Cell Host and Microbe, 2019
SUMMARY Inflammatory bowel disease (IBD) is characterized by alterations in the intestinal microbiota and altered immune responses to gut microbiota. Evidence is accumulating that IBD is influenced by not only commensal bacteria but also commensal fungi.
Jose J. Limon, Jie Tang, Da-Lin Li, Andrea J. Wolf, K. Michelsen, V. Funari, Matthew D Gargus, Christopher Nguyen, Purnima Sharma, Viviana I Maymi, I. Iliev, J. Skalski, Jordan Brown, C. Landers, J. Borneman, J. Braun, S. Targan, D. McGovern, D. Underhill   +18 more
semanticscholar   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

In situ PCR for Mycobacterium tuberculosis in endoscopic mucosal biopsy specimens of intestinal tuberculosis and Crohn disease [PDF]

, 2008
Tuberculosis and Crohn disease are granulomatous disorders affecting the intestinal tract with similar clinical manifestations and pathologic features.
Pulimood, AB, Rook, GWA, Peter, S, Donoghue, HD   +3 more
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