Results 131 to 140 of about 9,352,293 (347)

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

Mo1886 – Flagellin-Activated Cd4 Cells in Remission Crohn Disease Fail to Induce Epithelial Barrier Changes Despite Similar Activation Profiles to Cd4 Cells from Active Crohn’s Patients

, 2019
Peter Mannon, Nadine Morgan, Jiongru Wu
openalex   +1 more source

Therapy de‐escalation in pediatric patients with inflammatory bowel disease in remission: Data analysis from the CEDATA registry

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives There are no standardized criteria about stepping down from combination therapy (immunomodulator and tumor necrosis factor (TNF)‐alpha‐inhibitors) in children with inflammatory bowel disease (IBD) to reduce risk for side effects. Our aim was to describe how de‐escalation has been performed in a large pediatric cohort and to find ...
Sila Cekin, Christoph Huenseler, Serdar Cantez, Ilse Broekaert, Jan de Laffolie, CEDATA‐GPGE® Study Group   +5 more
wiley   +1 more source

Bardet-Biedl Syndrome, Crohn Disease, Primary Sclerosing Cholangitis, and Autoantibody Positive Thyroiditis: A Case Report and A Review of a Cohort of BBS Patients [PDF]

, 2012
Ugur Halac, Denise Herzog
openalex   +1 more source

Crohn Disease: Epidemiology, Diagnosis, and Management

Mayo Clinic proceedings, 2017
J. Feuerstein, A. Cheifetz
semanticscholar   +1 more source

Fatigue in pediatric inflammatory bowel disease: Explained by transdiagnostic and disease‐focused factors

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Fatigue is highly prevalent in children with inflammatory bowel disease (IBD), even during clinical remission. This suggests a role for transdiagnostic factors—lifestyle, psychological, and social influences not specific to the disease.
Maartje D. Stutvoet, Anouk Vroegindeweij, Tessa Z. Toonen, Merel M. Nap‐Van der Vlist, Johanna W. Hoefnagels, Anemone van den Berg, Sanne L. Nijhof   +6 more
wiley   +1 more source

Amino acid-responsive Crohn's disease: a case study

Clinical and Experimental Gastroenterology, 2010
Alvin Stein1, Marty Hinz2, Thomas Uncini31Stein Orthopedic Associates, Plantation, FL, USA; 2Clinical Research, NeuroResearch Clinics Inc., Cape Coral, FL, USA; 3Laboratory, Fairview Regional Medical Center-Mesabi, Hibbing, MN, USAPurpose: This paper ...
Alvin Stein, Marty Hinz, Thomas Uncini
doaj  

Combined Restitutive Therapy for Treatment of Immunosuppressive Refractory Crohn Disease

, 2013
Jason R. Goldsmith, Maureen T. Kelly, Katherine B. Freeman, Debora Duro   +3 more
openalex   +2 more sources

Crohn S Disease and Acne Fulminans as Associated Disoders (Case Report) [PDF]

, 2015
Klaudia Péčová, Karolína Vorčáková, Marcela Horáková, Lenka Vojarová   +3 more
openalex   +1 more source

Adequate vitamin D is associated with favorable disease outcome in children with inflammatory bowel disease receiving anti‐tumor necrosis factor alpha therapy

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Deficiency of serum 25‐hydroxyvitamin D [25(OH)D] was associated with decreased short‐term response to anti‐tumor necrosis factor‐alpha (TNF‐α) agents in adults with inflammatory bowel disease (IBD). The aim of this study was to evaluate the association between serum 25(OH)D levels and the outcome of children with IBD undergoing ...
Adi Anafy, Yaara Manor, Maayan Shemer, Reut Doyev, Eytan Damari, Shlomi Cohen, Anat Yerushalmy‐Feler   +6 more
wiley   +1 more source