Results 251 to 260 of about 58,502 (304)

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Comparison of volumetric and linear measurements of intestinal inflammation and treatment response in children with newly diagnosed ileal Crohn disease. [PDF]

Eur Radiol
Derinkuyu BE, Bard A, Naim I, Tkach JA, Denson LA, Dillman JR.   +5 more
europepmc   +1 more source

Effects of Common Food Additives Kappa‐, Iota‐ and Lambda‐Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption

Clinical &Experimental Allergy, EarlyView.
Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun, Yagiz Pat, Huseyn Babayev, Sena Ardicli, Ismail Ogulur, Xianting Bu, Manru Li, Shuqi Jia, Beate Rückert, Raja Dhir, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis, Duygu Yazici   +13 more
wiley   +1 more source

Fecal calprotectin as an inflammatory biomarker in small bowel Crohn disease. [PDF]

Porto Biomed J
Sousa MI, Dias E, Andrade P, Macedo G.
europepmc   +1 more source

Investigating the Effect of Tumour Necrosis Factor Antagonist on Olfaction

Clinical Otolaryngology, EarlyView.
ABSTRACT Objectives Tumour Necrosis factor antagonists is a potent anti‐inflammatory medication and has shown to improve olfactory function in murine models. The primary aim was to determine the effect of TNF antagonists on olfactory performance in humans.
Andreas Espehana, George Macfarlane, Elizabeth Mairenn Garden, Liam Lee, Gabija Klyvyte, Lavandan Jegatheeswaran, Rebecca Davies, Carl Philpott   +7 more
wiley   +1 more source

Machine Learning Modeling for Predicting Infliximab Pharmacokinetics in Pediatric and Young Adult Patients With Crohn Disease: Leveraging Ensemble Modeling With Synthetic and Real-World Data. [PDF]

Ther Drug Monit
Irie K, Minar P, Reifenberg J, Boyle BM, Noe JD, Hyams JS, Mizuno T.   +6 more
europepmc   +1 more source

[Histological and clinical overlap of hidradenitis suppurativa and Crohn disease under IL-17 inhibition]. [PDF]

Dermatologie (Heidelb)
Ocker L, Scheel C, Abu Rached N, Dörler M, Stücker M, Bechara F.   +5 more
europepmc   +1 more source

Exploration of the molecular linkage between endometriosis and Crohn disease by bioinformatics methods. [PDF]

Medicine (Baltimore)
Zhou W, Su P, Wang Y, Li Z, Li Z, Liu L.
europepmc   +1 more source

Guillain-Barré Syndrome in a Patient Receiving Anti-Tumor Necrosis Factor for Crohn Disease: Coincidence or Consequence? [PDF]

Am J Case Rep
Ferreira SDC, Vasconcelos JRO, Rezende REF, Aprile LRO, Troncon LEA.   +4 more
europepmc   +1 more source