Successful treatment of hidradenitis suppurativa in the setting of Crohn disease with combination adalimumab and ustekinumab [PDF]
, 2019 Herein we report the combination of adalimumab and ustekinumab to successfully treat a 39-year-old woman who presented for evaluation of hidradenitis suppurativa in the setting of Crohn disease of both the small and large intestine.
Cline, Abigail, Pichardo, Rita O
core
Diagnosing Crohn\u27s Disease: An economic analysis comparing wireless capsule endoscopy with traditional diagnostic procedures [PDF]
, 2004 The purpose of this study was to review economic considerations related to establishing a diagnosis of Crohn\u27s disease, and to compare the costs of a diagnostic algorithm incorporating wireless capsule endoscopy (WCE) with the current algorithm for ...
Fuhr, Joseph P., Jr. +6 more
core +1 more source
A Turing mechanism in order to explain the patchy nature of Crohn's disease [PDF]
arXiv, 2020 Crohn's disease is an inflammatory bowel disease (IBD) that is not well understood. In particular, unlike other IBDs, the inflamed parts of the intestine compromise deep layers of the tissue and are not continuous but separated and distributed through the whole gastrointestinal tract, displaying a patchy inflammatory pattern.
arxiv
Crohn's disease activity index and Vienna classification - Is it worthwhile to calculate before surgery? [PDF]
, 2006 Background: Crohn's disease (CD) patients with increased disease activity may reveal an increased risk for perioperative complications. The `Crohn's disease activity index' (CDAI) and the `Vienna classification' (VC) were developed for standardized ...
A. Beham +29 more
core +1 more source
Trees Assembling Mann Whitney Approach for Detecting Genome-wide Joint Association among Low Marginal Effect loci [PDF]
Genet Epidemiol. 2013 Jan;37(1):84-91, 2015 Common complex diseases are likely influenced by the interplay of hundreds, or even thousands, of genetic variants. Converging evidence shows that genetic variants with low marginal effects (LME) play an important role in disease development. Despite their potential significance, discovering LME genetic variants and assessing their joint association on
arxiv +1 more source
Network analysis of a complex disease: the gut microbiota in the inflammatory bowel disease case [PDF]
arXiv, 2022 Inflammatory bowel diseases (IBD) are complex diseases in which the gut microbiota is attacked by the immune system of genetically predisposed subjects when they are exposed to yet unclear environmental factors. The complexity of this class of diseases makes them suitable to be represented and studied with network science.
arxiv
Data Augmentation for Compositional Data: Advancing Predictive Models of the Microbiome [PDF]
arXiv, 2022 Data augmentation plays a key role in modern machine learning pipelines. While numerous augmentation strategies have been studied in the context of computer vision and natural language processing, less is known for other data modalities. Our work extends the success of data augmentation to compositional data, i.e., simplex-valued data, which is of ...
arxiv
Mycobacterium avium subspecies paratuberculosis bacteremia in type 1 diabetes mellitus: an infectious trigger? [PDF]
, 2008 Mycobacterium avium subspecies paratuberculosis (MAP) is the established cause of paratuberculosis in ruminants (i.e., Johne disease). The bacterium is shed in the milk of infected cows and survives pasteurization.
Paccagnini, Daniela +2 more
core
Clinico-pathologic, histophenotypic, molecular and prognostic characterization of small bowel carcinomas associated with celiac disease or Chron\u2019s disease. [PDF]
, 2018 Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Celiac disease and Crohn\u2019s disease are predisposing conditions for small bowel carcinoma development.
Vanoli, Alessandro
core
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis [PDF]
, 2014 Inflammatory bowel diseases (IBD) are emerging globally, indicating that environmental factors may be important in their pathogenesis. Colonic mucosal epigenetic changes, such as DNA methylation, can occur in response to the environment and have been ...
Bronsky, Jiri +10 more
core +2 more sources