Results 71 to 80 of about 328,667 (315)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Optimizing root spatial distribution during the flower-boll stage can reduce yield losses from square stage drought in cotton

BMC Plant Biology
Background Root spatial distribution, an important root function phenotype, is closely related to drought tolerance. Drought is known to hinder cotton development, but, the effects of drought at the square stage on the spatial distribution ...
Congcong Guo, Xiaoyuan Bao, Hongchun Sun, Hongjuan Zhao, Lingxiao Zhu, Yongjiang Zhang, Ke Zhang, Anchang Li, Cai Zhao, Liantao Liu, Cundong Li   +10 more
doaj   +1 more source

Crop growth models without hormones.

Netherlands Journal of Agricultural Science, 1983
For the simulation of organ formation and assimilate partitioning, information is required on the current level of activities like CO2 assimilation and the growth of various organs, as well as state variables such as leaf and root wt., N content and carbohydrate reserves and exogenous variables like radiation and temp.
de Wit, C.T., Penning de Vries, F.W.T.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Application of DSSAT crop model for wheat crop growth simulation in some wheat growing districts of northern India

, 2017
Process based Crop growth simulation models are being used as a potential decision support tool for informed decision making by policy makers and researchers.
KV Ramana, et al., Bhabhana Sahay, Anima Biswal   +2 more
core  

Use of Crop Models to Evaluate Crop Management

, 1996
Crop growth models are computer programs that compute daily growth of corn and soybeans based on daily weather (max/min temperature, rainfall, solar radiation) and management practices (planting date, variety, population, fertility, irrigation).
Batchelor, William, William D. Batchelor
core   +1 more source

Effects of iron tailings on the growth and physiological response of cool-season turfgrass

Grass Research
Over the past few decades, due to mining activity, a large amount of iron mine tailing sands have been deposited. Selection of appropriate plant species and studying their growth and physiological response under iron tailings are the key factors for ...
Ran Chen, Yuchan Zhu, Weikuo Han, Lu Chen, Xinru Guo, Xinyao Jin, Hanrui Li, Miao Jin, Lin Li, Chuntong Li, Yue Chen, Xinbo Sun   +11 more
doaj   +1 more source

Crop growth

, 2003
SWAP contains three crop growth routines: a simple model, a detailed model (WOFOST), and the same model attuned to simulate grass growth. The simple model describes crop development, independent of external stress factors.
van Dam, J.C., van Diepen, J.C., Huygen, J.   +2 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source