Results 61 to 70 of about 328,667 (315)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Exogenous Regulators Enhance Physiological Recovery and Yield Compensation in Maize Following Mechanical Leaf Damage

Agronomy
To elucidate how exogenous regulators mitigate the impact of mechanical leaf damage on maize, field experiments were conducted on two sowing dates (S1, S2) using two cultivars (XY335, ZD958). Severe leaf damage at the six-leaf stage significantly reduced
Aonan Jiang, Dahong Bian, Xushuang Chen, Qifan Yang, Zhongbo Wei, Xiong Du, Zhen Gao, Guangzhou Liu, Yanhong Cui   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Supplemental irrigation mitigates yield loss of maize through reducing canopy temperature under heat stress

Agricultural Water Management
Due to global warming, high temperature stress severely impacts maize growth and development, especially during the early filling stage. Supplemental irrigation is an effective measure to mitigate high temperature stress in maize. However, the underlying
Huajian Jian, Zhen Gao, Yingying Guo, Xinyan Xu, Xiaoyu Li, Meijia Yu, Guangzhou Liu, Dahong Bian, Yanhong Cui, Xiong Du   +9 more
doaj   +1 more source

HOW TO USE CROP GROWTH MODEL WOFOST FOR FORECASTING GROWTH AND YIELD OF A CROP

Journal of AgriSearch, 2016
WOFOST version 7.1.3 is a computer model that simulates the growth and production of annual field crops. All the run options are operational through a graphical user interface named WOFOST Control Center version 1.8 (WCC). WCC facilitates selecting the production level, and input data sets on crop, soil, weather, crop calendar, hydrological field ...
LAL SINGH, PARMEET SINGH, RAIHANA HABIB KANTH, PURUSHOTAM SINGH, SABIA AKHTER, AMAL SAXENA   +5 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exogenous melatonin improves cotton yield under drought stress by enhancing root development and reducing root damage

Journal of Integrative Agriculture
The exogenous application of melatonin by the root drenching method is an effective way to improve crop drought resistance. However, the optimal concentration of melatonin by root drenching and the physiological mechanisms underlying melatonin-induced ...
Lingxiao Zhu, Hongchun Sun, Ranran Wang, Congcong Guo, Liantao Liu, Yongjiang Zhang, Ke Zhang, Zhiying Bai, Anchang Li, Jiehua Zhu, Cundong Li   +10 more
doaj   +1 more source

Cotton seedling plants adapted to cadmium stress by enhanced activities of protective enzymes

Plant, Soil and Environment, 2016
Cotton (Gossypium hirsutum L.) is a global major crop with strong tolerance to abiotic stress, but its tolerance to cadmium (Cd) stress is unclear. The objective of this study was to determine the influence of Cd stress on the seedling growth and some ...
L.T. Liu, H.C. Sun, J. Chen, Y.J. Zhang, X.D. Wang, D.X. Li, C.D. Li   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

From field to globe: upscaling of crop growth modelling

, 2011
Recently, the scale of interest for application of crop growth models has extended to the region or even globe with time frames of 50-100 years. The application at larger scales of a crop growth model originally developed for a small scale without any ...
van Bussel, L.G.J., Bussel, L.G.J., van
core