Results 81 to 90 of about 687,728 (314)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

NO-TILL PROVIDES THE OPPORTUNITY TO MANAGE UNDERGROUND INTERACTIONS BETWEEN ARBUSCULAR MYCORRHIZAL FUNGI, WEEDS AND CROP PLANTS UNDER MEDITERRANEAN CONDITIONS [PDF]

, 2012
Early colonization of crop roots by arbuscular mycorrhiza (AM) is considered beneficial but its importance likely depends on the possible stresses faced by the host plant. Manganese toxicity is one such stress that AM can alleviate.
Alho, Luís, Brito, Isabel, Carvalho, Mário, Goss, Michael J.   +3 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cereal Crop Productivity in Developing Countries: Past Trends and Future Prospects [PDF]

This paper synthesizes the evidence on cereal crop productivity in developing countries over the past 30 years and looks at future prospects for productivity growth.
Heisey, Paul W., Pingali, Prabhu L.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Environmental effects on seed yield determination of irrigated peanut crops: Links with radiation use efficiency and crop growth rate

Field Crops Research, 2007
Abstract In Argentina, delayed sowing causes a decrease in seed yield and in radiation use efficiency (RUE) of peanut crops ( Arachis hypogaea L.), but it is not known if RUE reduction is mainly due to reduced temperature during late reproductive stages or to a sink limitation promoted by decreased seed number in these conditions.
Haro Juarez, Ricardo Javier, Otegui, María Elena, Collino, Daniel, Dardanelli, Julio Luis   +3 more
openaire   +2 more sources

Smallholders' Cost Efficiency in Mozambique: Implications for Improved Maize Seed Adoption [PDF]

Maize is an important staple in Mozambique. It is also a dominant crop produced by smallholder farmers. However, the actual maize yields, currently estimated at 1.4 tons/ha, fall short of potential yields of 5-6.5 tons/ha.
Christy, Ralph D., Mabaya, Edward T., Zavale, Helder   +2 more
core   +1 more source

Tillage Radish Planting Date x Seeding Rate Trial [PDF]

, 2016
Farmers are interested in growing tillage radishes as they may potentially offer many environmental and economic benefits. Tillage radishes are quick at scavenging excess nitrogen (N), provide good ground cover, and break down very quickly in the spring ...
Brigham, Nate, Cummings, Erica, Darby, Heather, Emick, Hillary, Gupta, Abha, Ziegler, Sara   +5 more
core   +1 more source

Spatial heterogeneity and irreversible vegetation change in semi-arid grazing systems [PDF]

, 2002
Recent theoretical studies have shown that spatial redistribution of surface water may explain the occurrence of patterns of alternating vegetated and degraded patches in semiarid grasslands.
Andel, J., van, Fryxell, J.M., Hearne, J., Klausmeier, C.A., Koppel, J., van de, Kumar, L., Langevelde, F., van, Prins, H.H.T., Ridder, N., de, Rietkerk, M., Skidmore, A.K., Stroosnijder, L.   +11 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source