Results 61 to 70 of about 480,425 (296)

Investigating the impacts of connected vehicle technology on the flow of trucks at the busiest Canada-U.S. border crossings

Transportation Research Interdisciplinary Perspectives
Land-border crossings between Canada and the United States facilitate the movement of approximately 59 % of the goods traded between the two countries. Consequently, these border facilities experience heavy truck traffic daily.
Hanna Maoh, Sidra Anis
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Entry Mode Choice of Multinational Banks [PDF]

, 2008
When expanding abroad, a multinational bank faces a trade-off between accessing a foreign country via cross border lending or a financial foreign direct investment, i.e. greenfield or acquisition entry.
Lehner, Maria
core   +4 more sources

Digital Storytelling and Cultural Identity in Romanian Memetic Discourse

Humanities
This article examines Romanian internet memes as cultural micro-narratives that encode social critique, identity negotiation, and emotional response through compressed, multimodal storytelling.
Alexandra-Monica Toma, Mihaela-Alina Ifrim   +1 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

CHIKV mRNA vaccines encoding conserved structural/envelope proteins confer broad cross-lineage protection against infection

Signal Transduction and Targeted Therapy
With the broad spread of the chikungunya virus (CHIKV), there is an increasing demand for more effective and broadly protective vaccines. Here, we designed CHIKV mRNA vaccines containing full-length structural proteins or part of structural proteins ...
Xiaoming Liang, Yanan Zhou, Yun Yang, Qianqian Li, Junbin Wang, Bai Li, Hao Yang, Cong Tang, Wenhai Yu, Haixuan Wang, Qing Huang, Hongyu Chen, Yuhuan Yan, Ran An, Dongdong Lin, Wenqi Quan, Yong Zhang, Yanwen Li, Xuena Du, Yuxia Yuan, Longhai Yuan, Jian Zhou, Qiangming Sun, Youchun Wang, Shuaiyao Lu   +24 more
doaj   +1 more source

Institutional and organizational features of cross-border cargo traffic in the post-soviet space integration terms. Part I [PDF]

, 2015
The article covers the technical, technological, institutional, and organizational barriers of cross-border transportation of cargo. The study uses an institutional approach as a methodological alternative to other approaches.
Ionicheva, V. N., Medkov, A. A., Tsvetkov, V. A., Zoidov, K. H.   +3 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source