Results 61 to 70 of about 4,312,000 (290)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Plate Food Waste in Early Childhood Education: Contextual and Nutritional Drivers with Implications for Sustainable Food Systems

Foods
Plate food waste (PFW) in early childhood education is a critical yet understudied issue in Eastern Europe, with implications for nutrition, sustainability, and food security.
Dimitrie Stoica, Monica Laura Zlati, Raisa Bălan (Stanciu), Carmelia Mariana Bălănică Dragomir, Cezar Ionuț Bichescu, Florentina-Loredana Dragomir-Constantin, Maricica Stoica   +6 more
doaj   +1 more source

Cross-Border Mergers and Cross-Border Takeovers Compared

, 2019
The EU rules on cross-border mergers provide a legal framework for the aggregation of firms across the borders of EU Member States (Directive (EU) 2017/1132). These rules are not alone in pursuing this aim, as the takeover bid directive (Directive 2004/25/EC) also contributes to fostering cross-border combinations of European firms.
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sustainable Management of Saline Ecosystems:

ACROSS
Land use monitoring is an essential tool for understanding landscape dynamics and assessing the ecological status of natural habitats, particularly in areas included in the European Natura 2000 network.
Camelia Mariana BĂLĂNICĂ DRAGOMIR, Ciprian CUZMIN, Aurel Gabriel SIMIONESCU, Viorel Marian DRAGOMIR   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cross Border Tourism and Regional Development: Case Indonesia-Timor Leste Cross Border

Ekuilibrium: Jurnal Ilmiah Bidan Ilmu Ekonomi, 2020
This study aims to: (i) describe the perception of stakeholder about cross border tourism in Wini Indonesia and the Oecusse-timor Leste, (ii) analyze the impact of cross border tourism on the regional development.
Werenfridus Taena, Felisisima Afoan
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source