Results 81 to 90 of about 349,174 (276)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Functionalization of heterocyclic compounds using polyfunctional magnesium and zinc reagents

Beilstein Journal of Organic Chemistry, 2011
In this review we summarize the most important procedures for the preparation of functionalized organzinc and organomagnesium reagents. In addition, new methods for the preparation of polyfunctional aryl- and heteroaryl zinc- and magnesium compounds, as ...
Paul Knochel, Matthias A. Schade, Sebastian Bernhardt, Georg Manolikakes, Albrecht Metzger, Fabian M. Piller, Christoph J. Rohbogner, Marc Mosrin   +7 more
doaj   +1 more source

Optimization of relativistic mean field model for finite nuclei to neutron star matter

, 2012
We have optimized the parameters of extended relativistic mean-field model using a selected set of global observables which includes binding energies and charge radii for nuclei along several isotopic and isotonic chains and the iso-scalar giant monopole
A. Sulaksono, Agrawal, Agrawal, B.K. Agrawal, Baym, Boguta, Bohigas, Carbone, Carriere, Chen, Chen, Chen, Danielewicz, Demorest, Dhiman, Estal, Fattoyev, Friedrich, Furnstahl, Furnstahl, Furnstahl, Gezerlis, Gmuca, Gmuca, Ishizuka, Klimkiewicz, Klüpfel, Klüpfel, Krasznahorkay, Krasznahorkay, Kumar, Lalazissis, Lalazissis, Long, Müller, Niksic, Niksic, P.-G. Reinhard, Piekarewicz, Ray, Reinhard, Reinhard, Ring, Roca-Maza, Ruster, Schaffner-Bielich, Serot, Serot, Sil, Steiner, Sugahara, Tamii, Terashima, Todd-Rutel, Trzcinska, Typel, Walecka, Youngblood, Özel   +58 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Solid-phase synthesis of biaryl bicyclic peptides containing a 3-aryltyrosine or a 4-arylphenylalanine moiety

Beilstein Journal of Organic Chemistry, 2019
A methodology for the solid-phase synthesis of biaryl bicyclic peptides containing a Phe-Phe, a Phe-Tyr or a Tyr-Tyr motif has been devised. This approach comprises two key steps.
Iteng Ng-Choi, Àngel Oliveras, Lidia Feliu, Marta Planas   +3 more
doaj   +1 more source

3,4′,5,5′-Tetramethoxy-2′-methylbiphenyl-4-ol

IUCrData, 2019
The asymmetric unit of the title compound, C17H20O5, contains two independent molecules, A and B, with similar geometries [dihedral angles between the phenyl rings = 56.19 (8) and 54.98 (7)°, respectively].
Barbara Gleede, Elisabeth K. Oehl, Dieter Schollmeyer, Siegfried R. Waldvogel   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Compensation of Cross-Coupling in MIMO Inductive Power Transfer Systems

IEEE Access
This paper proposes a design principle for reactance compensation circuit for multiple-input multiple-output (MIMO) inductive power transfer (IPT) where the primary side employs a coil array to send power to a receiving coil array located at the ...
Quoc-Trinh Vo, Yugo Sakamaki, Quang-Thang Duong, Minoru Okada   +3 more
doaj   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source