Results 51 to 60 of about 505,829 (274)

Joint Reconstruction via Coupled Bregman Iterations with Applications to PET-MR Imaging

, 2017
Joint reconstruction has recently attracted a lot of attention, especially in the field of medical multi-modality imaging such as PET-MRI. Most of the developed methods rely on the comparison of image gradients, or more precisely their location ...
Brinkmann, Eva-Maria, Burger, Martin, Rasch, Julian   +2 more
core   +1 more source

The intertropical convergence zone modulates intense hurricane strikes on the western North Atlantic margin [PDF]

, 2016
© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 6 (2016): 21728, doi:10.1038/srep21728Most Atlantic hurricanes form in the Main ...
A Higuera-Gundy, AK Hastings, B Aguirre, BRB Gregory, BW Bird, C Saenger, CM Moy, CS Lane, DA Hodell, DA Hodell, DA Willard, DJ Vimont, DW Gamble, DW Steadman, DW Steadman, E Gischler, E Kjellmark, GA Milne, GH Haug, IM Dima, JA Lee-Thorp, JCH Chiang, JD Woodruff, JD Woodruff, JE Mylroie, JL Franklin, JP Donnelly, JP Kossin, JP Kossin, JW Teeter, K Rotzoll, KA Emanuel, KC Denomee, KR Knapp, LG Thompson, M Blaauw, M Jury, MA Caffrey, MB Lawrence, MC Bove, ME Mann, MR Toomey, N Lin, P Ceppi, P Chang, P Chang, P Lane, PJ Reimer, PJ van Hengstum, R Bertrand, S Holding, S Rahmstorf, S Waldeab, SA Marcott, SB Goldenberg, T Doi, T Schneider, TR Knutson, WM Gray, WS Broecker   +59 more
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Feature Importance in Gradient Boosting Trees with Cross-Validation Feature Selection

Entropy, 2022
Gradient Boosting Machines (GBM) are among the go-to algorithms on tabular data, which produce state-of-the-art results in many prediction tasks. Despite its popularity, the GBM framework suffers from a fundamental flaw in its base learners. Specifically,
Afek Ilay Adler, Amichai Painsky
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Boosting Multitask Decomposition: Directness, Sequentiality, Subsampling, Cross-Gradients

sponsorship: This study was supported by the Hungarian National Research, Development, and Innovation Office K 139330 grant; the European Union (EU) Joint Program on Neurodegenerative Disease (JPND) Grant SOLID JPND2021-650-233; the National Research, Development, and Innovation Fund of Hungary under Grant TKP2021-EGA-02, the European Union project RRF-
Millinghoffer, Andras, Antal, Matyas, Marosi, Mark, Formanek, Andras, Antos, Andras, Antal, Peter   +5 more
openaire   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Cooper pair splitting controlled by a temperature gradient

Beilstein Journal of Nanotechnology, 2023
Electrons in two different normal metallic electrodes attached to a sufficiently thin superconducting island may become entangled due to the effect of Cooper pair splitting.
Dmitry S. Golubev, Andrei D. Zaikin
doaj   +1 more source