Results 1 to 10 of about 665,514 (191)

Mapping Hsp104 interactions using cross‐linking mass spectrometry [PDF]

FEBS Open Bio
Molecular machines from the AAA+ (ATPases Associated with diverse cellular Activity) superfamily of protein disaggregases play important roles in protein folding, disaggregation and DNA processing.
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
doaj   +2 more sources

Oncogenic BRCA1,2 Mutations in the Human Lineage—A By-Product of Sexual Selection?

Biomedicines, 2023
In this review, we discuss the long-known problem of tissue-specific carcinogenesis in BRCA1 and BRCA2 mutation carriers: while the genes are expressed ubiquitously, increased cancer risk is observed mostly in the breast and ovaries, and to a much lesser
Tatyana V. Korneenko, Nikolay B. Pestov
doaj   +1 more source

At the Crossroads of the cGAS-cGAMP-STING Pathway and the DNA Damage Response: Implications for Cancer Progression and Treatment

Pharmaceuticals, 2023
The evolutionary conserved DNA-sensing cGAS-STING innate immunity pathway represents one of the most important cytosolic DNA-sensing systems that is activated in response to viral invasion and/or damage to the integrity of the nuclear envelope.
Tatyana V. Korneenko, Nikolay B. Pestov, Ivan A. Nevzorov, Alexandra A. Daks, Kirill N. Trachuk, Olga N. Solopova, Nickolai A. Barlev   +6 more
doaj   +1 more source

Systematic review and Meta-analysis comparing modified cross-linking and standard cross-linking for progressive keratoconus [PDF]

International Journal of Ophthalmology, 2017
AIM: To compare the effectiveness and safety between modified cross-linking (MC) and standard cross-linking (SC) in mild or moderate progressive keratoconus.
Yang Liu, Yi Liu, Ying-Nan Zhang, Ai-Peng Li, Jing Zhang, Qing-Feng Liang, Ying Jie, Zhi-Qiang Pan   +7 more
doaj   +1 more source

Short- and long-term safety and efficacy of corneal collagen cross-linking in progressive keratoconus: A systematic review and m eta-analysis of randomized controlled trials

Taiwan Journal of Ophthalmology, 2023
PURPOSE: The purpose of the study is to evaluate the safety and outcomes of corneal collagen cross-linking (CXL) and different CXL protocols in progressive keratoconus (PK) population at short and long-term.
Phulen Sarma, Hardeep Kaur, Farhad Hafezi, Jaimini Bhattacharyya, Richard Kirubakaran, Manisha Prajapat, Bikash Medhi, Kalyan Das, Ajay Prakash, Ashutosh Singh, Subodh Kumar, Rahul Singh, Dibbanti Harikrishna Reddy, Gurjeet Kaur, Saurabh Sharma, Anusuya Bhattacharyya   +15 more
doaj   +1 more source

Clinical outcomes at one year following keratoconus treatment with accelerated transepithelial cross-linking [PDF]

International Journal of Ophthalmology, 2017
This study evaluated the clinical outcomes in keratoconus corneas following accelerated transepithelial corneal collagen cross-linking (CXL) (Avedro KXL® system, Waltham, MA, USA) over one year of follow-up.
Alberto Artola, David P. Piñero, Pedro Ruiz-Fortes, Roberto Soto-Negro, Rafael J Pérez-Cambrodí   +4 more
doaj   +1 more source

Trans-epithelial accelerated corneal cross-linking for keratoconus in children [PDF]

International Journal of Ophthalmology, 2017
The aim of the study is to evaluate the safety and efficacy of trans-epithelial accelerated corneal cross-linking (TE-ACXL) in children with progressive keratoconus. Retrospective, case-series of 23 eyes of 14 children who underwent TE-ACXL.
Andrew Olivo-Payne, Juan Carlos Serna-Ojeda, Erick Hernandez-Bogantes, Alexandra Abdala-Figuerola, Lucero Pedro-Aguilar, Alejandro Lichtinger, Arturo Ramirez-Miranda, Alejandro Navas, Enrique O. Graue-Hernandez   +8 more
doaj   +1 more source

Results of Accelerated Local Cross-Linking in Keratoconus

Oftalʹmologiâ, 2023
Objective of the study. To analyze the effectiveness of accelerated local corneal cross linking in the treatment of keratoconus (KC). Patients and methods.
H. Khraistin, G. A. Osipyan, S. I. Anisimov, A. K. Dzamikhova, M. Jourieh   +4 more
doaj   +1 more source

Cross-linking of dermal sheep collagen using a water-soluble carbodiimide [PDF]

, 1996
A cross-linking method for collagen-based biomaterials was developed using the water-soluble carbodiimide 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC).
Dijkstra, P.J., Feijen, J., Luyn, M.J.A. van, Nieuwenhuis, P., Olde Damink, L.H.H., Wachem, P.B. van   +5 more
core   +4 more sources

Recent advances in corneal collagen cross-linking

Indian Journal of Ophthalmology, 2017
Corneal collagen cross-linking has become the preferred modality of treatment for corneal ectasia since its inception in late 1990s. Numerous studies have demonstrated the safety and efficacy of the conventional protocol.
Gitansha Shreyas Sachdev, Mahipal Sachdev   +1 more
doaj   +1 more source