Results 61 to 70 of about 681,701 (308)
Collagen cross-linking beyond corneal ectasia: A comprehensive review
Indian Journal of OphthalmologyThe history of corneal cross-linking (CXL) dates back to 2003 when some German scientists investigated possible treatments to harden the corneal structure to increase its resistance in ectatic corneal diseases.
Grigory A Osipyan +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Indian Journal of OphthalmologyPurpose: To evaluate changes in corneal backscattering after collagen cross-linking (CXL) for progressive keratoconus and compare its course with different techniques – standard epithelium-off CXL (SCXL), contact lens-assisted CXL (CACXL), and ...
Barkha Gupta +5 more
doaj +1 more source
BMC Ophthalmology, 2019 Background To investigate the efficacy and safety of the retention ring-assisted continuous application of 0.1% riboflavin in pulsed-light accelerated corneal collagen cross-linking on the progression of keratoconus.
Chung Young Kim, Mee Kum Kim
doaj +1 more source
Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor [PDF]
, 2012 G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of their ligand-binding sites are ...
Abrol, Ravinder +5 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Advantages of orthogonal folding of single polymer chains to soft nanoparticles [PDF]
, 2014 We investigate, by means of computer simulations, the formation of soft nanoparticles by irreversible intramolecular cross-linking of homofunctional polymer precursors in good solvent.
Arbe, Arantxa +5 more
core +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
MODERN TRENDS IN THE TREATMENT OF KERATOKONUS IN CHILDREN
Oftalʹmologiâ, 2017 Keratoconus is a progressive degenerative corneal disease. It causes a disruption in the structure and organization of the corneal collagen matrix and leads to its thinning and protrusion.
E. Y. Markova +3 more
doaj +1 more source
Packing defects and the width of biopolymer bundles
, 2007 The formation of bundles composed of actin filaments and cross-linking proteins is an essential process in the maintenance of the cells' cytoskeleton.
L. D. Landau, Lord Rayleigh, Nir S. Gov
core +1 more source