Results 81 to 90 of about 681,701 (308)

Antibody-mediated cross-linking of gut bacteria hinders the spread of antibiotic resistance [PDF]

, 2019
The body is home to a diverse microbiota, mainly in the gut. Resistant bacteria are selected for by antibiotic treatments, and once resistance becomes widespread in a population of hosts, antibiotics become useless. Here, we develop a multiscale model of
Bansept, Florence, Bitbol, Anne-Florence, Loverdo, Claude, Marrec, Loïc   +3 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Effect of Age Factor on Corneal Cross-linking Treatment of Keratoconus Patients

Türk Oftalmoloji Dergisi, 2012
Pur po se: To evaluate the effect of age on corneal cross-linking treatment in keratoconus patients. Ma te ri al and Met hod: We retrospectively evaluated forty-nine eyes of 45 patients with keratoconus that were applied corneal cross-linking treatment.
Lokman Aslan, Ahmet Metin Başkan, Erdem Yüksel, Murat Aslankurt, Murat Özdemir   +4 more
doaj   +1 more source

Cross-linking reconsidered: binding and cross-linking fields and the cellular response

Biophysical Journal, 1996
We analyze a model for the reversible cross-linking of cell surface receptors by a collection of bivalent ligands with different affinities for the receptor as would be found in a polyclonal anti-receptor serum. We assume that the amount of cross-linking determines, via a monotonic function, the rate at which cells become activated and divide.
Sulzer, B., Boer, R.J. de, Perelson, A.S.   +2 more
openaire   +3 more sources

Glassy states and microphase separation in cross-linked homopolymer blends

, 2004
The physical properties of blends of distinct homopolymers, cross-linked beyond the gelation point, are addressed via a Landau approach involving a pair of coupled order-parameter fields: one describing vulcanisation, the other describing local phase ...
A Zippelius, Brazovskii S. A., C Wald, Castillo H. E., de Gennes P. G., Deam R. T., P. M Goldbart, Wald C.   +7 more
core   +1 more source

Viscoelastic behaviour of polymethyl methacrylate networks with different crosslinking degrees [PDF]

, 2004
The influence of the cross-linking degree on the dynamics of the segmental motions close to the glass transition of poly(methyl methacrylate), PMMA, networks was investigated by three different mechanical spectroscopy techniques: thermally stimulated ...
Alves N. M., Angell C. A., Doulut S., Fulcher G. A., Guth E., Gómez Ribelles J. L., Ilavský M., Ito K., J. A. Gómez Tejedor, J. F. Mano, J. L. Gómez Ribelles, Lacabanne C., N. M. Alves, Ngai K. L., Ngai K. L., Perez J., Vogel H., Williams M. L.   +17 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Standard versus transepithelial collagen cross-linking in the management of keratoconus

Delta Journal of Ophthalmology, 2018
Objective The aim of this study was to compare corneal collagen cross-linking (CXL) using either standard or transepithelial CXL. Patients and methods The study included 30 eyes of 18 patients with a mean age of 27.08 years.
Abd El-Magid M Tag El-Din, Magdy E.E Tawakol, Amr M.M Sheta   +2 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The efficacy and safety of corneal collagen cross-linking in progressive keratoconus with regard to long-term results

Офтальмохирургия, 2016
Purpose. To evaluate the efficacy and safety of a modified technique of corneal collagen cross-linking in comparison with the standard approach by the nature changes in clinical and morphological parameters of the cornea in the early and longterm ...
E. G. Solodkova, V. P. Fokin, S. V. Balalin, I. A. Melikhova   +3 more
doaj   +1 more source