Results 251 to 260 of about 183,904 (311)
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Chemical Cross-Linking: Reagents and Problems in Studies of Membrane Structure
Annual Review of Biochemistry, 1977INTRODUCTION AND PERSPECTIVE ....... 524 THE PROCEDURE AND THE PROBLEMS. . . . . .... ...... . . .. . ... . . .... .... . 525 CHEMISTRY OF SELECTED REAGENTS 527 Alkyl Imidates (lmidoesters} 527 Synthesis 528 Reaction paths and mechanisms 528 Use as modifYing reagents 531 Acyl Azides 532 Sulfhydryl Reagents 532 Nitrenes 534 ...
K, Peters, F M, Richards
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Cross-linking reagents and membrane organization
Trends in Biochemical Sciences, 1979Abstract Bifunctional cross-linking reagents have been widely used to study quaternary structure in oligomeric enzymes — their application to membrane systems involves a new level of problems but is proving informative.
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Bifunctional imidoesters as cross-linking reagents
Biochemical and Biophysical Research Communications, 1966Abstract Bifunctional small molecule reagents have been important in the study of a number of problems in protein chemistry (cf. Wold, 1961 a, b; Zahn and Meienhofer, 1958 ; Singer, 1959 ). For most purposes it is desirable that the chemical modifications produced by the bifunctional reagent cause as little alteration as possible in the conformation
A, Dutton, M, Adams, S J, Singer
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Synthesis of “long,” hydrophilic, protein-cross-linking reagents
Analytical Biochemistry, 1974Abstract Since most of the protein cross-linking reagents in use are strongly hydrophobic, their length cannot be increased beyond approximately 20 A between the protein-reactive groups, before denaturation of most proteins becomes noticeable at already a very few cross-links per molecule.
K, Wetz, H, Fasold, C, Meyer
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A new nucleic acid-protein cross-linking reagent
Molecular and General Genetics MGG, 1977A new photoactivable reagent is described, which allows the formation of RNA-protein cross-links via disulfide bridges in combination with mercaptobutyrimidate. The reconstituted L24 protein-23S RNA complex from the large subunit of E. coli ribosomes has been used as a model system for the cross-linking.
Oste, Christian +3 more
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An amino acid-based heterofunctional cross-linking reagent
Amino Acids, 2014We describe the synthesis and characterization of a new lysine-based heterofunctional cross-linking reagent. It carries two readily available aminooxy functionalities and an activated and protected thiol group that is capable of generating reducible disulfides, the former enable bioorthogonal modification of ketones and aldehydes by the formation of an
Lelle, M., Peneva, K.
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A novel cross-linking reagent for bovine hemoglobin modification
Biotechnology Letters, 2003A novel cross-linking reagent, methoxypolyethelene glycol-glutamic acid, was synthesized and used to modify bovine hemoglobin. Bis-tetrameric hemoglobin with moderate affinity for O2 was obtained under the controlled reaction conditions.
Minglei, He +3 more
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An Allylstannane Reagent on Non-Cross-Linked Polystyrene Support
Organic Letters, 1999[reaction: see text] A new allylstannane reagent on non-cross-linked polystyrene was developed for the first time. This support differs markedly from standard cross-linked polymers because it is completely soluble in organic solvents; moreover, the reactions can be conveniently monitored directly by standard 1H NMR methods.
E J, Enholm +4 more
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Novel DNA Cross-Linking Reagents
2016Abstract DNA interstrand cross-links (ICLs) are the sources of the cytotoxicity of many anticancer agents. DNA cross-linking agents are used as anticancer agents, for DNA damage and repair study, for nucleic acid detection, and for construction of DNA nanomaterials.
Heli Fan, Xiaohua Peng
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