Results 71 to 80 of about 170,253 (336)

Effect of S-triazine Ring Substitution on the Synthesis of Organic Resorcinol-Formaldehyde Xerogels

open access: yesGels, 2020
Resorcinol (R) and formaldehyde (F) gel synthesis has been well-studied along with alternative reagents. We present the synthesis of formaldehyde-based xerogels using chemically similar s-triazine precursors, with comparison to traditional analogues. The
Martin Prostredný   +4 more
doaj   +1 more source

Liesegang patterns: Effect of dissociation of the invading electrolyte

open access: yes, 1998
The effect of dissociation of the invading electrolyte on the formation of Liesegang bands is investigated. We find, using organic compounds with known dissociation constants, that the spacing coefficient, 1+p, that characterizes the position of the n-th
Antal T.   +21 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

How does Cross-Linking Effect the Thermal Stability of Polyisoprene [PDF]

open access: yes, 2000
Polyisoprene can be cross-linked by an initial lithiation followed by reaction with both monochloro compounds and dichloro compounds. The monochloro compounds effect crosslinking through a lithium-chlorine exchange route while the use of dichloro ...
Wilkie, Charles A., Yao, Qiang
core   +1 more source

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]

open access: yes, 2008
Alum is used as a vaccine adjuvant and induces T<sub>h</sub>2 responses and T<sub>h</sub>2-driven antibody isotype production against co-injected antigens.
A. S. McKee   +45 more
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Studies on B Cells in the Fruit-Eating Black Flying Fox (Pteropus alecto)

open access: yesFrontiers in Immunology, 2019
The ability of bats to act as reservoir for viruses that are highly pathogenic to humans suggests unique properties and functional characteristics of their immune system.
Pravin Periasamy   +17 more
doaj   +1 more source

Modulation of the slow/common gating of CLC channels by intracellular cadmium. [PDF]

open access: yes, 2015
Members of the CLC family of Cl(-) channels and transporters are homodimeric integral membrane proteins. Two gating mechanisms control the opening and closing of Cl(-) channels in this family: fast gating, which regulates opening and closing of the ...
Chen, Tsung-Yu   +3 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces [PDF]

open access: yes, 2011
TRIM proteins play important roles in the innate immune defense against retroviral infection, including human immunodeficiency virus type-1 (HIV-1). Rhesus macaque TRIM5α (TRIM5αrh) targets the HIV-1 capsid and blocks infection at an early post-entry ...
A Desai   +64 more
core   +5 more sources

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