Results 111 to 120 of about 6,630,927 (326)

Bivalent Human Papillomavirus Vaccine Effectiveness in a Japanese Population: High Vaccine-Type–Specific Effectiveness and Evidence of Cross-Protection

Journal of Infectious Diseases, 2018
Background Proactive recommendations for human papillomavirus (HPV) vaccines in Japan have been suspended for 5 years because of safety concerns. While no scientific evidence exists to substantiate these concerns, one reason given for not reinstating ...
R. Kudo, M. Yamaguchi, M. Sekine, S. Adachi, Y. Ueda, E. Miyagi, M. Hara, S. Hanley, T. Enomoto   +8 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Reducing Campylobacter jejuni colonization in broiler chickens by in-feed supplementation with hyperimmune egg yolk antibodies [PDF]

, 2019
Campylobacter infections sourced mainly to poultry products, are the most important bacterial foodborne zoonoses worldwide. No effective measures to control these infections in broiler production exist to date.
Canessa, Stefano, De Zutter, Lieven, Garmyn, An, Haesebrouck, Freddy, Heyndrickx, Marc, Martel, An, Pasmans, Frank, Van Rysselberghe, Nathalie, Vandeputte, Jasmien   +8 more
core   +1 more source

Partial cross-protection between Japanese encephalitis virus genotype I and III in mice

PLoS Neglected Tropical Diseases, 2019
Genotype III (GIII) Japanese encephalitis virus (JEV) predominance has gradually been replaced by genotype I (GI) over the last 20 years in many Asian countries.
Jianchao Wei, Xin Wang, Junjie Zhang, Shuang Guo, Linlin Pang, Kun Shi, Ke Liu, Donghua Shao, Yafeng Qiu, Lihong Liu, F. Widén, Beibei Li, Zhiyong Ma   +12 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evaluation of Different Machine Learning Approaches to Predict Antigenic Distance Among Newcastle Disease Virus (NDV) Strains

Viruses
Newcastle disease virus (NDV) continues to present a significant challenge for vaccination due to its rapid evolution and the emergence of new variants.
Giovanni Franzo, Alice Fusaro, Chantal J. Snoeck, Aleksandar Dodovski, Steven Van Borm, Mieke Steensels, Vasiliki Christodoulou, Iuliana Onita, Raluca Burlacu, Azucena Sánchez Sánchez, Ilya A. Chvala, Mia Kim Torchetti, Ismaila Shittu, Mayowa Olabode, Ambra Pastori, Alessia Schivo, Angela Salomoni, Silvia Maniero, Ilaria Zambon, Francesco Bonfante, Isabella Monne, Mattia Cecchinato, Alessio Bortolami   +22 more
doaj   +1 more source

Post-hoc analysis from phase III trials of human papillomavirus vaccines: considerations on impact on non-vaccine types

Expert Review of Vaccines, 2019
Background: Substantial heterogeneity has been reported in efficacy against high-grade cervical intraepithelial neoplasia (CIN) irrespective of HPV type in phase III results for bivalent and quadrivalent human papillomavirus virus (HPV) vaccines (AS04 ...
Martin Ryser, Valérie Berlaimont, Naveen Karkada, Attila Mihalyi, Rino Rappuoli, Robbert van der Most   +5 more
doaj   +1 more source

High Salt Cross-Protects Escherichia coli from Antibiotic Treatment through Increasing Efflux Pump Expression

mSphere, 2018
Environmental stresses often co-occur when bacteria encounter antibiotic treatment inside the human body. The cellular response to environmental stressors can alter the global gene expression pattern of bacteria.
Manlu Zhu, Xiongfeng Dai
doaj   +1 more source

Heartwater surveillance in Guadeloupe: a model of partnership between research and surveillance for the Caribbean [PDF]

, 2012
Heartwater, a tick-borne disease of ruminants transmitted by Amblyomma ticks is present in 3 Caribbean islands: Guadeloupe, Marie-Galante and Antigua, representing a threat for neighboring islands and North America.
Faverjon, Céline, Gerbier, Guillaume, Laurent, Marion, Lefrançois, Thierry, Pradel, Jennifer, Redon, Jean-Marc, Teissier, R., Vachiery, Nathalie   +7 more
core  

Immunity in society: diverse solutions to common problems [PDF]

, 2012
Understanding how organisms fight infection has been a central focus of scientific research and medicine for the past couple of centuries, and a perennial object of trial and error by humans trying to mitigate the burden of disease.
Babayan, S.A., Schneider, D.S.
core   +3 more sources