Results 81 to 90 of about 6,630,927 (326)

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül, Neriman Sıla Koç, Berrak Itır Aylı   +2 more
wiley   +1 more source

Advances and Future Challenges in Recombinant Adenoviral Vectored H5N1 Influenza Vaccines

Viruses, 2012
The emergence of a highly pathogenic avian influenza virus H5N1 has increased the potential for a new pandemic to occur. This event highlights the necessity for developing a new generation of influenza vaccines to counteract influenza disease.
Jianfeng Zhang
doaj   +1 more source

Impact of viral drift on vaccination dynamics and patterns of seasonal influenza [PDF]

, 2013
BACKGROUND: Much research has been devoted to the determination of optimal vaccination strategies for seasonal influenza epidemics. However, less attention has been paid to whether this optimization can be achieved within the context of viral drift ...
Seyed M Moghadas, Yanyu Xiao
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Cross-protective immunity to influenza A viruses

Expert Review of Vaccines, 2010
Antigenic changes in influenza virus occur gradually, owing to mutations (antigenic drift), and abruptly, owing to reassortment among subtypes (antigenic shift). Availability of strain-matched vaccines often lags behind these changes, resulting in a shortfall in public health.
Suzanne L, Epstein, Graeme E, Price
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Can social protection tackle emerging risks from climate change, and how? A framework and a critical review

Climate Risk Management, 2023
Climate change is transforming the risks individuals and households face, with potentially profound socioeconomic consequences such as increased poverty, inequality, and social instability.
Cecilia Costella, Maarten van Aalst, Yola Georgiadou, Rachel Slater, Rachel Reilly, Anna McCord, Rebecca Holmes, Jonathan Ammoun, Valentina Barca   +8 more
doaj   +1 more source

Seropositivity to non-vaccine incorporated genotypes induced by the bivalent and quadrivalent HPV vaccines: A systematic review and meta-analysis. [PDF]

, 2017
BACKGROUND: Human papillomavirus vaccines have demonstrated remarkable efficacy against persistent infection and disease associated with vaccine-incorporated genotypes and a degree of efficacy against some genetically related, non-vaccine-incorporated ...
Beddows, Simon, Bissett, Sara L, Godi, Anna, Jit, Mark   +3 more
core   +2 more sources

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

Nature Communications, 2022
Cross-reactive immune responses to SARS-CoV-2 have been observed in pre-pandemic cohorts and proposed to contribute to host protection. Here we assess 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV-2 ...
R. Kundu, J. Narean, Lulu Wang, J. Fenn, T. Pillay, N. Fernandez, E. Conibear, A. Koycheva, M. Davies, M. Tolosa-Wright, S. Hakki, R. Varro, E. McDermott, Sarah Hammett, Jessica Cutajar, R. Thwaites, E. Parker, Carolina Rosadas, Myra O. McClure, R. Tedder, Graham W. Taylor, J. Dunning, A. Lalvani   +22 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source